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852918-02-6,MFCD06683895
Catalog No.:AA00G54F

852918-02-6 | 3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide

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1mg
≥95%
in stock  
$58.00   $40.00
- +
5mg
in stock  
$163.00   $115.00
- +
10mg
≥95%
in stock  
$225.00   $157.00
- +
25mg
in stock  
$419.00   $293.00
- +
50mg
in stock  
$668.00   $468.00
- +
100mg
in stock  
$1,109.00   $777.00
- +
500mg
in stock  
$3,439.00   $2,407.00
- +
1000mg
in stock  
$5,464.00   $3,825.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00G54F
Chemical Name:
3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide
CAS Number:
852918-02-6
Molecular Formula:
C21H17ClFN3O4S
Molecular Weight:
461.8938
MDL Number:
MFCD06683895
SMILES:
O=C(c1ccc(cc1)CNS(=O)(=O)c1ccc(c(c1)Cl)F)NNC(=O)c1ccccc1
Properties
Computed Properties
 
Complexity:
719  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  
XLogP3:
3.6  

Literature

Title: TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner.

Journal: Neuropharmacology 20120901

Title: Subtype selective NMDA receptor antagonists induce recovery of synapses lost following exposure to HIV-1 Tat.

Journal: British journal of pharmacology 20120601

Title: Subunit-selective allosteric inhibition of glycine binding to NMDA receptors.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120502

Title: Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors.

Journal: The Journal of pharmacology and experimental therapeutics 20101201

Title: Bettini E, et, al. Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors. J Pharmacol Exp Ther. 2010 Dec; 335(3): 636-44.

Title: Edman S, et, al. TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner. Neuropharmacology. 2012 Sep; 63(3): 441-9.

Title: Bu F, et, al. NR2A contributes to genesis and propagation of cortical spreading depression in rats. Sci Rep. 2016 Mar 22;6:23576.

Title: Shatillo A, et, al. Involvement of NMDA receptor subtypes in cortical spreading depression in rats assessed by fMRI. Neuropharmacology. 2015 Jun; 93:164-70.

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Tags:852918-02-6 Molecular Formula|852918-02-6 MDL|852918-02-6 SMILES|852918-02-6 3-Chloro-4-fluoro-N-[4-[[2-(phenylcarbonyl)hydrazino]carbonyl]benzyl]benzenesulfonamide