Home Pyridines 85371-64-8
85371-64-8,MFCD00242745
Catalog No.:AA004OUW

85371-64-8 | Guanidine,N-cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)-, hydrate (1:1)

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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA004OUW
Chemical Name:
Guanidine,N-cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)-, hydrate (1:1)
CAS Number:
85371-64-8
Molecular Formula:
C13H19N5
Molecular Weight:
245.3235
MDL Number:
MFCD00242745
SMILES:
CC(C(C)(C)C)N=C(Nc1ccncc1)NC#N
Properties
Computed Properties
 
Complexity:
327  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
1  

Downstream Synthesis Route

[1]Baeten,Mattijs;Maes,BertU.W.[AdvancedSynthesisandCatalysis,2016,vol.358,#5,p.826-833]

Literature

Title: Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel.

Journal: The Journal of biological chemistry 20171020

Title: Rotenone induces KATP channel opening in PC12 cells in association with the expression of tyrosine hydroxylase.

Journal: Oncology reports 20121001

Title: Alteration of ATP-sensitive K+ channels in rabbit aortic smooth muscle during left ventricular hypertrophy.

Journal: American journal of physiology. Cell physiology 20120715

Title: Pinacidil pretreatment improves vascular reactivity after shock through PKCα and PKCε in rats.

Journal: Journal of cardiovascular pharmacology 20120601

Title: Combined effects of the ATP-sensitive potassium channel opener pinacidil and simvastatin on pulmonary vascular remodeling in rats with monocrotaline-induced pulmonary arterial hypertension.

Journal: Die Pharmazie 20120601

Title: Inhibition of uterine contractility with various tocolytics with and without progesterone: in vitro studies.

Journal: American journal of obstetrics and gynecology 20120301

Title: Properties and functions of KATP during mouse perinatal development.

Journal: Biochemical and biophysical research communications 20120203

Title: Hypoxia and reoxygenation modulate the arrhythmogenic activity of the pulmonary vein and atrium.

Journal: Clinical science (London, England : 1979) 20120201

Title: [The changes of metabolism in myocardium at ischemia-reperfusion and activating of the ATP-sensitive potassium channels].

Journal: Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20120101

Title: Vasodilation of retinal arterioles induced by activation of BKCa channels is attenuated in diabetic rats.

Journal: European journal of pharmacology 20111101

Title: Vasodilation induced by oxygen/glucose deprivation is attenuated in cerebral arteries of SUR2 null mice.

Journal: American journal of physiology. Heart and circulatory physiology 20111001

Title: Agonist-induced periodic vasomotion in rat isolated pulmonary artery.

Journal: Fundamental & clinical pharmacology 20110801

Title: Effects of potassium channel modulators on myogenic spontaneous phasic contractile activity in human detrusor from neurogenic patients.

Journal: BJU international 20110801

Title: Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts.

Journal: Journal of molecular and cellular cardiology 20110801

Title: Ontogeny of sulfonylurea-binding regulatory subunits of K(ATP) channels in the pregnant rat myometrium.

Journal: Reproduction (Cambridge, England) 20110701

Title: Modulation of the 6-position of benzopyran derivatives and inhibitory effects on the insulin releasing process.

Journal: Bioorganic & medicinal chemistry 20110701

Title: Hydrogen sulfide dilates cerebral arterioles by activating smooth muscle cell plasma membrane KATP channels.

Journal: American journal of physiology. Heart and circulatory physiology 20110601

Title: Inhibitory effect of caffeine on pacemaker activity in the oviduct is mediated by cAMP-regulated conductances.

Journal: British journal of pharmacology 20110601

Title: Effect of potassium channel opener pinacidil on the contractions elicited electrically or by noradrenaline in the human radial artery.

Journal: European journal of pharmacology 20110311

Title: Cirrhosis decreases vasoconstrictor response to electrical field stimulation in rat mesenteric artery: role of calcitonin gene-related peptide.

Journal: Experimental physiology 20110301

Title: Participation of BKCa2+ and KATP potassium ion channels in the contractility of human term pregnant myometrium in in vitro conditions.

Journal: The journal of obstetrics and gynaecology research 20110301

Title: Sarcolemmal cardiac K(ATP) channels as a target for the cardioprotective effects of the fluorine-containing pinacidil analogue, flocalin.

Journal: British journal of pharmacology 20110201

Title: Role of vascular K(ATP) channels in blood pressure variability after sinoaortic denervation in rats.

Journal: Acta pharmacologica Sinica 20110201

Title: Activation of ATP-sensitive potassium channels antagonize nociceptive behavior and hyperexcitability of DRG neurons from rats.

Journal: Molecular pain 20110101

Title: [Ontogeny of sulphonylurea-binding regulatory subunits of K(ATP) channels in the pregnant rat myometrium].

Journal: Acta pharmaceutica Hungarica 20110101

Title: Both mitochondrial KATP channel opening and sarcolemmal KATP channel blockage confer protection against ischemia/reperfusion-induced arrhythmia in anesthetized male rats.

Journal: Journal of cardiovascular pharmacology and therapeutics 20101201

Title: Diazoxide maintenance of myocyte volume and contractility during stress: evidence for a non-sarcolemmal K(ATP) channel location.

Journal: The Journal of thoracic and cardiovascular surgery 20101101

Title: Effects of K openers on the QT prolongation induced by HERG-blocking drugs in guinea-pigs.

Journal: The Journal of pharmacy and pharmacology 20100701

Title: A study of the relationship between pharmacologic preconditioning and adenosine triphosphate-sensitive potassium (KATP) channels on cultured cardiomyocytes using the microelectrode array.

Journal: Journal of cardiovascular pharmacology 20100701

Title: Genotype-phenotype correlation in tissue models of Brugada syndrome simulating patients with sodium and calcium channelopathies.

Journal: Heart rhythm 20100601

Title: Hydrogen sulfide attenuates epithelial-mesenchymal transition of human alveolar epithelial cells.

Journal: Pharmacological research 20100401

Title: Prolonged donor heart preservation with pinacidil: the role of mitochondria and the mitochondrial adenosine triphosphate-sensitive potassium channel.

Journal: The Journal of thoracic and cardiovascular surgery 20100401

Title: Pinacidil-primed ATP-sensitive potassium channels mediate feedback control of mechanical power output in isolated myocardium of rats and guinea pigs.

Journal: European journal of pharmacology 20100225

Title: K(ATP) channel openers protect mesencephalic neurons against MPP+-induced cytotoxicity via inhibition of ROS production.

Journal: Journal of neuroscience research 20100201

Title: Inhibition of oxygen consumption in skeletal muscle-derived mitochondria by pinacidil, diazoxide, and glibenclamide, but not by 5-hydroxydecanoate.

Journal: Journal of bioenergetics and biomembranes 20100201

Title: Pharmacological stimulation and inhibition of insulin secretion in mouse islets lacking ATP-sensitive K+ channels.

Journal: British journal of pharmacology 20100201

Title: Lipopolysaccharides up-regulate Kir6.1/SUR2B channel expression and enhance vascular KATP channel activity via NF-kappaB-dependent signaling.

Journal: The Journal of biological chemistry 20100129

Title: Differential K(ATP) channel pharmacology in intact mouse heart.

Journal: Journal of molecular and cellular cardiology 20100101

Title: Hydrogen sulfide opens the KATP channel on rat atrial and ventricular myocytes.

Journal: Cardiology 20100101

Title: Direct effects of K(ATP) channel openers pinacidil and diazoxide on oxidative phosphorylation of mitochondria in situ.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101

Title: Effects of nicorandil on the cAMP-dependent Cl- current in guinea-pig ventricular cells.

Journal: Journal of pharmacological sciences 20100101

Title: Effects of imatinib mesylate in interstitial cells of Cajal from murine small intestine.

Journal: Biological & pharmaceutical bulletin 20100101

Title: [Effect of a new activator of adenosine triphosphate-sensitive potassium channels flocalin on the glucose level in blood].

Journal: Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20100101

Title: New R/S-3,4-dihydro-2,2-dimethyl-2H-1-benzopyrans as K(ATP) channel openers: modulation of the 4-position.

Journal: Bioorganic & medicinal chemistry 20091115

Title: Excitotoxicity in rat's brain induced by exposure of manganese and neuroprotective effects of pinacidil and nimodipine.

Journal: Biological trace element research 20091101

Title: Interstitial cells of Cajal generate spontaneous transient depolarizations in the rat gastric fundus.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20091001

Title: Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats.

Journal: Gastroenterology 20090801

Title: Caveolin-3 negatively regulates recombinant cardiac K(ATP) channels.

Journal: Biochemical and biophysical research communications 20090731

Title: The phenomenon of seasonal pseudohypokalemia: effects of ambient temperature, plasma glucose and role for sodium-potassium-exchanging-ATPase.

Journal: Clinical biochemistry 20090601

Title: Effect of ATP-sensitive potassium channel agonists on sympathetic hyperinnervation in postinfarcted rat hearts.

Journal: American journal of physiology. Heart and circulatory physiology 20090601

Title: Functional K(ATP) channels in the rat retinal microvasculature: topographical distribution, redox regulation, spermine modulation and diabetic alteration.

Journal: The Journal of physiology 20090515

Title: Loss of functional K+ channels encoded by ether-à-go-go-related genes in mouse myometrium prior to labour onset.

Journal: The Journal of physiology 20090515

Title: Molecular and functional characterization of a new potassium conductance in mouse ventricular fibroblasts.

Journal: Journal of molecular and cellular cardiology 20090401

Title: Regulation of ATP-sensitive K+ channels by caveolin-enriched microdomains in cardiac myocytes.

Journal: Cardiovascular research 20090401

Title: Blockade of K(ATP) channels reduces endothelial hyperpolarization and leukocyte recruitment upon reperfusion after hypoxia.

Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20090401

Title: Dispersion of repolarization and arrhythmogenesis.

Journal: Heart rhythm 20090401

Title: Restitution, heterogeneity and unidirectional conduction block: New roles for old players.

Journal: Heart rhythm 20090401

Title: Pinacidil relaxing effect on phenylephrine-precontracted guinea pig aorta was abolished by pretreatment with 17-beta-estradiol.

Journal: International journal of cardiology 20090320

Title: Downregulation of Kir6.1/SUR2B channels in the obese rat aorta.

Journal: Nutrition (Burbank, Los Angeles County, Calif.) 20090301

Title: The use of microelectrode array (MEA) to study the protective effects of potassium channel openers on metabolically compromised HL-1 cardiomyocytes.

Journal: Physiological measurement 20090201

Title: Contribution of RhoA kinase and protein kinase C to weak relaxant effect of pinacidil on carbachol-induced contractions in sensitized guinea-pig trachealis.

Journal: Archives of pharmacal research 20090201

Title: [Effect of adenosine triphosphate-dependent potassium channel activators on electrical reactions of intact and cultured endothelial cells].

Journal: Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20090101

Title: The influence of animal species on the relationship between ATP-sensitive potassium ion channels and defense reflexes of the airways.

Journal: Bratislavske lekarske listy 20090101

Title: Dissection of two Cx37-independent conducted vasodilator mechanisms by deletion of Cx40: electrotonic versus regenerative conduction.

Journal: American journal of physiology. Heart and circulatory physiology 20081101

Title: Insulin-like growth factor-I inhibits rat arterial K(ATP) channels through pI 3-kinase.

Journal: Biochemical and biophysical research communications 20081003

Title: K+ channel inhibition modulates the biochemical and morphological differentiation of human placental cytotrophoblast cells in vitro.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20081001

Title: Sulfonylurea receptor-dependent and -independent pathways mediate vasodilation induced by ATP-sensitive K+ channel openers.

Journal: Molecular pharmacology 20080901

Title: Opening of microglial K(ATP) channels inhibits rotenone-induced neuroinflammation.

Journal: Journal of cellular and molecular medicine 20080901

Title: Activated Rho/Rho kinase and modified calcium sensitivity in cryopreserved human saphenous veins.

Journal: Cryobiology 20080801

Title: Decreased expression of aortic KIR6.1 and SUR2B in hypertension does not correlate with changes in the functional role of K(ATP) channels.

Journal: European journal of pharmacology 20080610

Title: Role of sarcolemmal ATP-sensitive K+ channels in the regulation of sinoatrial node automaticity: an evaluation using Kir6.2-deficient mice.

Journal: The Journal of physiology 20080601

Title: New R/S-3,4-dihydro-2,2-dimethyl-6-halo-4-(phenylaminothiocarbonylamino)-2H-1-benzopyrans structurally related to (+/-)-cromakalim as tissue-selective pancreatic beta-cell K(ATP) channel openers.

Journal: Bioorganic & medicinal chemistry 20080515

Title: K(ATP) channel expression and pharmacological in vivo and in vitro studies of the K(ATP) channel blocker PNU-37883A in rat middle meningeal arteries.

Journal: British journal of pharmacology 20080501

Title: KATP channel openers have opposite effects on mitochondrial respiration under different energetic conditions.

Journal: Journal of cardiovascular pharmacology 20080501

Title: Upregulation of ATP-sensitive potassium channels for estrogen-mediated cell proliferation in human uterine leiomyoma cells.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20080501

Title: Protective effect of melatonin on Ca2+ homeostasis and contractility in acute cholecystitis.

Journal: Journal of pineal research 20080401

Title: Effect of ATP-sensitive potassium channel agonists on ventricular remodeling in healed rat infarcts.

Journal: Journal of the American College of Cardiology 20080401

Title: Evaluation of myorelaxant activity of 7-substituted hexahydroquinoline derivatives in isolated rabbit gastric fundus.

Journal: European journal of medicinal chemistry 20080301

Title: Diclofenac exerts local anesthetic-like actions on rat masseter muscle afferent fibers.

Journal: Brain research 20080215

Title: Brazilein-induced contraction of rat arterial smooth muscle involves activation of Ca2+ entry and ROK, ERK pathways.

Journal: European journal of pharmacology 20080212

Title: Vasodilator effects of adenosine on retinal arterioles in streptozotocin-induced diabetic rats.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20080201

Title: Inhibitory effects of different ATP-sensitive potassium channel openers on electrically generated and carbachol-induced contractions of porcine and human detrusor muscle.

Journal: Fundamental & clinical pharmacology 20080201

Title: Treatment for periodic paralysis.

Journal: The Cochrane database of systematic reviews 20080123

Title: Iptakalim inhibited endothelin-1-induced proliferation of human pulmonary arterial smooth muscle cells through the activation of K(ATP) channel.

Journal: Vascular pharmacology 20080101

Title: Synthesis of 2-methyl-4-aryl-4,6,7,8-tetrahydro-5(1H)-quinolone derivatives and their effects on potassium channels.

Journal: Arzneimittel-Forschung 20080101

Title: [Cardioprotective effects of flokalin: relative role of activation of sarcolemmal and mitochondrial adenosine triphosphate-dependent potassium channels].

Journal: Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20080101

Title: Effect of pravastatin on sympathetic reinnervation in postinfarcted rats.

Journal: American journal of physiology. Heart and circulatory physiology 20071201

Title: KATP channels confer survival advantage in cocaine overdose.

Journal: Molecular psychiatry 20071201

Title: Effects of prostaglandin E1 on vascular ATP-sensitive potassium channels.

Journal: Journal of cardiovascular pharmacology 20071201

Title: Voltage-gated Ca2+ currents are necessary for slow-wave propagation in the canine gastric antrum.

Journal: American journal of physiology. Cell physiology 20071101

Title: The role of potassium ion channels in cough and other reflexes of the airways.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20071101

Title: Angiotensin II-activated protein kinase C targets caveolae to inhibit aortic ATP-sensitive potassium channels.

Journal: Cardiovascular research 20071001

Title: Involvement of KATP and KvLQT1 K+ channels in EGF-stimulated alveolar epithelial cell repair processes.

Journal: American journal of physiology. Lung cellular and molecular physiology 20071001

Title: The effect of potassium channel opener pinacidil on the non-pregnant rat uterus.

Journal: Basic & clinical pharmacology & toxicology 20070901

Title: Effects of extracellular HCO3(-) on fatigue, pHi, and K+ efflux in rat skeletal muscles.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20070801

Title: Spontaneous oscillatory contractions in aortas of rats with arterial pressure lability caused by sinoaortic denervation.

Journal: Clinical and experimental pharmacology & physiology 20070801

Title: ATP-sensitive potassium channel: a novel target for protection against UV-induced human skin cell damage.

Journal: Journal of cellular physiology 20070701

Title: Arginine vasopressin inhibits Kir6.1/SUR2B channel and constricts the mesenteric artery via V1a receptor and protein kinase C.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20070701

Title: Vasodilator effect of nicorandil on retinal blood vessels in rats.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20070701

Title: Effect of K+ATP channel and adenosine receptor blockade during rest and exercise in congestive heart failure.

Journal: Circulation research 20070608

Title: Role of L-type calcium channels and PKC in active tone development in rabbit coronary artery.

Journal: American journal of physiology. Heart and circulatory physiology 20070601

Title: Verrucotoxin inhibits KATP channels in cardiac myocytes through a muscarinic M3 receptor-PKC pathway.

Journal: European journal of pharmacology 20070601

Title: Inhibition of KATP channels in the rat tail artery by neurally released noradrenaline acting on postjunctional alpha2-adrenoceptors.

Journal: The Journal of physiology 20070601

Title: Reduction of dispersion of repolarization and prolongation of postrepolarization refractoriness explain the antiarrhythmic effects of quinidine in a model of short QT syndrome.

Journal: Journal of cardiovascular electrophysiology 20070601

Title: Potassium channel opener pinacidil induces relaxation of the isolated human radial artery.

Journal: Journal of pharmacological sciences 20070601

Title: [Effects of preconditioning on the responsiveness of superior mesenteric artery after hemorrhagic shock in rats].

Journal: Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20070501

Title: Pinacidil reduces neuronal apoptosis following cerebral ischemia-reperfusion in rats through both mitochondrial and death-receptor signal pathways.

Journal: Neuroscience bulletin 20070501

Title: Hypotonic stress enhances slope conductivity of ATP-sensitive K+ channels activated pharmacologically.

Journal: International journal of cardiology 20070404

Title: ATP-sensitive potassium channels expressed by human monocytes play a role in stasis-induced thrombogenesis via tissue factor pathway.

Journal: Life sciences 20070220

Title: Electrophysiological and pharmacological characterization of the K(ATP) channel involved in the K+-current responses to FSH and adenosine in the follicular cells of Xenopus oocyte.

Journal: The journal of physiological sciences : JPS 20070201

Title: Effect of KATP channel openers on myogenic and neurogenic responses in goat urinary bladder.

Journal: Indian journal of experimental biology 20070201

Title: Identification of two types of ATP-sensitive K+ channels in rat ventricular myocytes.

Journal: Life sciences 20070102

Title: Differences in arrhythmogenicity between the canine right ventricular outflow tract and anteroinferior right ventricle in a model of Brugada syndrome.

Journal: Heart rhythm 20070101

Title: [Comparative study of the effects of new fluorine-containing pinacidyl analogs on bladder contractile function and vessel tone].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20070101

Title: Role of ATP-dependent potassium channels in pulmonary vascular tone of fetal lambs with congenital diaphragmatic hernia.

Journal: Pediatric research 20061101

Title: A key role for the subunit SUR2B in the preferential activation of vascular KATP channels by isoflurane.

Journal: British journal of pharmacology 20061101

Title: Actions of ZD0947, a novel ATP-sensitive K+ channel opener, on membrane currents in human detrusor myocytes.

Journal: British journal of pharmacology 20061101

Title: Selective inhibition of pinacidil effects by estrogen in guinea pig heart.

Journal: International journal of cardiology 20060607

Title: K(+)-evoked [(3)H]-norepinephrine release in human brain slices from epileptic and non-epileptic patients is differentially modulated by gabapentin and pinacidil.

Journal: Neuroscience research 20060601

Title: Effects of anthocyanidin derivative (HK-008) on relaxation in rat perfused mesenterial bed.

Journal: Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20060601

Title: Cellular basis for trigger and maintenance of ventricular fibrillation in the Brugada syndrome model: high-resolution optical mapping study.

Journal: Journal of the American College of Cardiology 20060516

Title: Effects of systemic administration of iptakalim on extracellular neurotransmitter levels in the striatum of unilateral 6-hydroxydopamine-lesioned rats.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Cocaine-induced inhibition of ATP-sensitive K+ channels in rat ventricular myocytes and in heart-derived H9c2 cells.

Journal: Basic & clinical pharmacology & toxicology 20060501

Title: Action of imipramine on activated ATP-sensitive K(+) channels in interstitial cells of Cajal from murine small intestine.

Journal: Life sciences 20060411

Title: Dimethyl lithospermate B, an extract of Danshen, suppresses arrhythmogenesis associated with the Brugada syndrome.

Journal: Circulation 20060321

Title: Impact of in vivo preconditioning by isoflurane on adenosine triphosphate-sensitive potassium channels in the rat heart: lasting modulation of nucleotide sensitivity during early memory period.

Journal: Anesthesiology 20060301

Title: In vivo characterization of monolithic matrix type transdermal drug delivery systems of pinacidil monohydrate: a technical note.

Journal: AAPS PharmSciTech 20060301

Title: The nitric oxide-cyclic GMP-protein kinase G-K+ channel pathway participates in the antiallodynic effect of spinal gabapentin.

Journal: European journal of pharmacology 20060215

Title: The regulation of rotenone-induced inflammatory factor production by ATP-sensitive potassium channel expressed in BV-2 cells.

Journal: Neuroscience letters 20060213

Title: Loss of mitochondrial membrane potential is associated with increase in mitochondrial volume: physiological role in neurones.

Journal: Journal of cellular physiology 20060201

Title: Adenosine- and hypoxia-induced dilation of human coronary resistance arteries: evidence against the involvement of K(ATP) channels.

Journal: British journal of pharmacology 20060201

Title: Involvement of potassium channels in hypoglycemic effect of sertraline.

Journal: Indian journal of experimental biology 20060201

Title: KATP channels in mouse spermatogenic cells and sperm, and their role in capacitation.

Journal: Developmental biology 20060115

Title: Initiation of remote microvascular preconditioning requires K(ATP) channel activity.

Journal: American journal of physiology. Heart and circulatory physiology 20060101

Title: Effects of pharmacological modulation of the ATP-sensitive potassium channels on the development of warm-up angina pectoris.

Journal: Cardiology 20060101

Title: Relaxant responses to calcium channel antagonists and potassium channel opener in human saphenous vein.

Journal: Autonomic & autacoid pharmacology 20060101

Title: The cardioprotective peptide, urocortin, activates cardiac KATP channels in adult rat.

Journal: Protein and peptide letters 20060101

Title: Analysis of responses to kava kava in the feline pulmonary vascular bed.

Journal: Journal of medicinal food 20060101

Title: Investigation of the relaxant effects of pinacidil and cromakalim on the sheep sphincter of Oddi.

Journal: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20060101

Title: Electrotonic transmission within pericyte-containing retinal microvessels.

Journal: Microcirculation (New York, N.Y. : 1994) 20060101

Title: [Effects of ATP-regulated potassium channels modulators, N-(2-pyridyl)-N'-(4-toluol) sulfonylcarbamides, on electromechanical activity in guinea pig myocardium].

Journal: Medicina (Kaunas, Lithuania) 20060101

Title: [Correction of mitochondrial respiration processes in rats with different resistance to hypoxia under stress by modulators of ATP-sensitive potassium channels].

Journal: Biomeditsinskaia khimiia 20060101

Title: KATP channel conductance of descending vasa recta pericytes.

Journal: American journal of physiology. Renal physiology 20051201

Title: Evidence that activation following failed defibrillation is not caused by triggered activity.

Journal: Journal of cardiovascular electrophysiology 20051101

Title: The puzzle of defibrillation: putting the pieces together.

Journal: Journal of cardiovascular electrophysiology 20051101

Title: Characterization of K(ATP)-channels in rat basilar and middle cerebral arteries: studies of vasomotor responses and mRNA expression.

Journal: European journal of pharmacology 20051031

Title: Effects of pine needle extract on pacemaker currents in interstitial cells of Cajal from the murine small intestine.

Journal: Molecules and cells 20051031

Title: Reduced effectiveness of HMR 1098 in blocking cardiac sarcolemmal K(ATP) channels during metabolic stress.

Journal: Journal of molecular and cellular cardiology 20051001

Title: Glibenclamide reveals role for endothelin in hypoxia-induced vasoconstriction in rat intrapulmonary arteries.

Journal: Journal of cardiovascular pharmacology 20051001

Title: [Effects of iptakalim on intracellular calcium concentrations, PKA and PKC activities in rat tail artery smooth muscle cells].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20051001

Title: Progress towards a more physiologic approach to donor heart preservation: the advantages of hyperpolarized arrest.

Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20050901

Title: Effects of calcium channel blocker, mibefradil, and potassium channel opener, pinacidil, on the contractile response of mid-pregnant goat myometrium.

Journal: Indian journal of experimental biology 20050901

Title: 2-(1-Hexyn-1-yl)adenosine-induced intraocular hypertension is mediated via K+ channel opening through adenosine A2A receptor in rabbits.

Journal: European journal of pharmacology 20050822

Title: Effect of thimerosal on arrhythmia induced by coronary ligation: the involvement of ATP-dependent potassium channels.

Journal: International heart journal 20050701

Title: Fasudil prevents KATP channel-induced improvement in postischemic functional recovery.

Journal: American journal of physiology. Heart and circulatory physiology 20050601

Title: SUR, ABC proteins targeted by KATP channel openers.

Journal: Journal of molecular and cellular cardiology 20050601

Title: Effect of the ATP-sensitive potassium channel opener ZM226600 on cystometric parameters in rats with ligature-intact, partial urethral obstruction.

Journal: European journal of pharmacology 20050523

Title: Doxapram stimulates the carotid body via a different mechanism than hypoxic chemotransduction.

Journal: Respiratory physiology & neurobiology 20050512

Title: Pretreatment with pinacidil promotes arrhythmias in an isolated tissue model of cardiac ischemia and reperfusion.

Journal: The Journal of pharmacology and experimental therapeutics 20050501

Title: 150-kD oxygen-regulated protein is an essential factor for insulin release.

Journal: Pancreas 20050501

Title: Effects of pinacidil on proliferation of cultured rabbit airway smooth muscle cells induced by endothelin-1.

Journal: Chinese medical journal 20050405

Title: Role of KATP channels in the regulation of rat dura and pia artery diameter.

Journal: Cephalalgia : an international journal of headache 20050401

Title: [Effects of quinidine on pinacidil-induced transmural dispersion of repolarization in canine right ventricular wall].

Journal: Zhonghua xin xue guan bing za zhi 20050401

Title: Pacemaker potentials generated by interstitial cells of Cajal in the murine intestine.

Journal: American journal of physiology. Cell physiology 20050301

Title: Endothelin-1 acts via protein kinase C to block KATP channels in rabbit coronary and pulmonary arterial smooth muscle cells.

Journal: Journal of cardiovascular pharmacology 20050201

Title: [Regulatory effects of nucleotides on ATP-sensitive potassium channel opener pinacidil-induced vascular relaxation].

Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20050201

Title: Reciprocal changes in endothelium-derived hyperpolarizing factor- and nitric oxide-system in the mesenteric artery of adult female rats following ovariectomy.

Journal: British journal of pharmacology 20050101

Title: Alteration of binding sites for [3H]P1075 and [3H]glibenclamide in renovascular hypertensive rat aorta.

Journal: Acta pharmacologica Sinica 20050101

Title: [The comparative study of the effect of new fluorine-containing guanidine-derivate compounds and pinacidil on contractile function of the urinary bladder in vitro].

Journal: Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20050101

Title: Pinacidil increases diclofenac antinociception in the formalin test.

Journal: Proceedings of the Western Pharmacology Society 20050101

Title: [Effect of adenosine triphosphate-sensitve potassium channel activator flokalin on the isolated heart functions].

Journal: Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20050101

Title: Voltage dependence of ATP-dependent K+ current in rat cardiac myocytes is affected by IK1 and IK(ACh).

Journal: The Journal of physiology 20041201

Title: KATP-channel-induced vasodilation is modulated by the Na,K-pump activity in rabbit coronary small arteries.

Journal: British journal of pharmacology 20041201

Title: [Iptakalim enhances astrocytic glutamate uptake activity].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20041201

Title: Caveolae localize protein kinase A signaling to arterial ATP-sensitive potassium channels.

Journal: Circulation research 20041112

Title: Testosterone induces cytoprotection by activating ATP-sensitive K+ channels in the cardiac mitochondrial inner membrane.

Journal: Circulation 20041109

Title: Pinacidil improves contractile function and intracellular calcium handling in isolated cardiac myocytes exposed to simulated cardioplegic arrest.

Journal: The Annals of thoracic surgery 20040901

Title: Donor heart preservation with pinacidil: the role of the mitochondrial K ATP channel.

Journal: The Annals of thoracic surgery 20040801

Title: A novel mechanism of regulation of cardiac contractility by mitochondrial functional state.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040801

Title: Fabrication and evaluation of polymeric films for transdermal delivery of pinacidil.

Journal: Die Pharmazie 20040801

Title: Evaluation of antipruritic effects of several agents on scratching behavior by NC/Nga mice.

Journal: European journal of pharmacology 20040714

Title: ATP-sensitive potassium channels are involved in adenosine-induced reduction of blood pressure variability in spontaneously hypertensive rats.

Journal: Journal of cardiovascular pharmacology 20040701

Title: Potassium channel openers are uncoupling protonophores: implication in cardioprotection.

Journal: FEBS letters 20040618

Title: Hypotonic stress increases efficacy of rilmakalim, but not pinacidil, to activate ATP-sensitive K(+) current in guinea pig ventricular myocytes.

Journal: Journal of pharmacological sciences 20040601

Title: Cardiovascular effects of the toxin(s) of the Australian paralysis tick, Ixodes holocyclus, in the rat.

Journal: Toxicon : official journal of the International Society on Toxinology 20040601

Title: Endothelium-derived hyperpolarizing factor-mediated renal vasodilatory response is impaired during acute and chronic hyperhomocysteinemia.

Journal: Circulation 20040518

Title: Molecular identity and function in transepithelial transport of K(ATP) channels in alveolar epithelial cells.

Journal: American journal of physiology. Lung cellular and molecular physiology 20040501

Title: Potassium channel dysfunction in cerebral arteries of insulin-resistant rats is mediated by reactive oxygen species.

Journal: Stroke 20040401

Title: Pharmacological modulation of the ATP sensitive potassium channels during repeated coronary occlusions: no effect on myocardial ischaemia or function.

Journal: Heart (British Cardiac Society) 20040401

Title: Pharmacological activation of plasma-membrane KATP channels reduces reoxygenation-induced Ca(2+) overload in cardiac myocytes via modulation of the diastolic membrane potential.

Journal: British journal of pharmacology 20040301

Title: Isoflurane and sevoflurane precondition against neutrophil-induced contractile dysfunction in isolated rat hearts.

Journal: Anesthesiology 20040301

Title: Contribution of reactive oxygen species to isoflurane-induced sensitization of cardiac sarcolemmal adenosine triphosphate-sensitive potassium channel to pinacidil.

Journal: Anesthesiology 20040301

Title: Uncomplicated rapid posthypothermic rewarming alters cerebrovascular responsiveness.

Journal: Stroke 20040201

Title: Molecular mechanisms of the inhibitory effects of propofol and thiamylal on sarcolemmal adenosine triphosphate-sensitive potassium channels.

Journal: Anesthesiology 20040201

Title: Mechanism of ST elevation and ventricular arrhythmias in an experimental Brugada syndrome model.

Journal: Circulation 20040106

Title: Unusual effects of a QT-prolonging drug, arsenic trioxide, on cardiac potassium currents.

Journal: Circulation 20040106

Title: Analysis of responses to St. John's Wort in the feline pulmonary vascular bed.

Journal: Journal of herbal pharmacotherapy 20040101

Title: [Effect of K-ATP channel opener-pinacidil on the liver mitochondria function in rats with different resistance to hypoxia during stress].

Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20040101

Title: Analysis of responses to valerian root extract in the feline pulmonary vascular bed.

Journal: Journal of alternative and complementary medicine (New York, N.Y.) 20031201

Title: Nicorandil inhibits the release of TNFalpha from a lymphocyte cell line and peripheral blood lymphocytes.

Journal: International immunopharmacology 20031101

Title: Cerebrovascular vasodilation to extraluminal acidosis occurs via combined activation of ATP-sensitive and Ca2+-activated potassium channels.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20031001

Title: ATP-sensitive K+ channel openers: old drugs with new clinical benefits for the heart.

Journal: Current vascular pharmacology 20031001

Title: Molecular basis and characteristics of KATP channel in human corporal smooth muscle cells.

Journal: International journal of impotence research 20030801

Title: The NO-cGMP-K+ channel pathway participates in the antinociceptive effect of diclofenac, but not of indomethacin.

Journal: Pharmacology, biochemistry, and behavior 20030801

Title: ATP-dependent potassium channels involved in the cardiac protection induced by intermittent hypoxia against ischemia/reperfusion injury.

Journal: Life sciences 20030725

Title: Effect of high concentration of glucose on dopamine release from pheochromocytoma-12 cells.

Journal: Metabolism: clinical and experimental 20030701

Title: ATP-sensitive potassium channels in rat primary afferent neurons: the effect of neuropathic injury and gabapentin.

Journal: Neuroscience letters 20030612

Title: K-ATP channel independent effects of pinacidil on ATP production in isolated cardiomyocyte or pancreatic beta-cell mitochondria.

Journal: Biochemical pharmacology 20030601

Title: NADH supplementation decreases pinacidil-primed I K ATP in ventricular cardiomyocytes by increasing intracellular ATP.

Journal: British journal of pharmacology 20030601

Title: [Effect of pinacidil on rat myocardial calcium regulation].

Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20030601

Title: SNC-80-induced preconditioning: selective activation of the mitochondrial adenosine triphosphate-gated potassium channel.

Journal: Journal of cardiovascular pharmacology 20030501

Title: Myocardial protection of immature rabbits: polarizing versus depolarizing.

Journal: The Journal of surgical research 20030501

Title: Potassium channel activators based on the benzopyran substructure: synthesis and activity of the C-8 substituent.

Journal: Bioorganic & medicinal chemistry 20030417

Title: Modulation of slow waves by hyperpolarization with potassium channel openers in antral smooth muscle of the guinea-pig stomach.

Journal: The Journal of physiology 20030401

Title: Adenine nucleotide translocase mediates the K(ATP)-channel-openers-induced proton and potassium flux to the mitochondrial matrix.

Journal: Journal of bioenergetics and biomembranes 20030401

Title: Synthesis and biological activity of 3,3-diamino-sulfonylacrylonitriles as novel inhibitors of glucose induced insulin secretion from beta cells.

Journal: Bioorganic & medicinal chemistry 20030320

Title: Effects of L-type Ca(2+)-channel blockade, K(+)(ATP)-channel opening and nitric oxide on human uterine contractility in relation to gestational age and labour.

Journal: Molecular human reproduction 20030301

Title: Selective mitochondrial KATP channel activation by nicorandil and 3-pyridyl pinacidil results in antiarrhythmic effect in an anesthetized rabbit model of myocardial ischemia/reperfusion.

Journal: Methods and findings in experimental and clinical pharmacology 20030301

Title: Modulation of the trafficking efficiency and functional properties of ATP-sensitive potassium channels through a single amino acid in the sulfonylurea receptor.

Journal: The Journal of biological chemistry 20030227

Title: An endothelium-derived factor modulates purinergic neurotransmission to mesenteric arterial smooth muscle of hamster.

Journal: European journal of pharmacology 20030214

Title: Contribution of Na+ -Ca2+ exchanger to pinacidil-induced relaxation in the rat mesenteric artery.

Journal: British journal of pharmacology 20030201

Title: Isoflurane sensitizes the cardiac sarcolemmal adenosine triphosphate-sensitive potassium channel to pinacidil.

Journal: Anesthesiology 20030101

Title: Gender differences in effects of pinacidil but not diazoxide on heart automatism in the isolated guinea pig right atria.

Journal: Polish journal of pharmacology 20030101

Title: Pinacidil-induced opening, like glibenclamide-induced closure of cardiac KATP channels, protects cardiac function against ischemia in isolated, working, erythrocyte perfused rat hearts.

Journal: Advances in experimental medicine and biology 20030101

Title: [Role of ATP-sensitive potassium channel activators in liver mitochondrial function in rats with different resistance to hypoxia].

Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20030101

Title: Cardiomyocyte mitochondrial KATP channels participate in the antiarrhythmic and antiinfarct effects of KATP activators during ischemia and reperfusion in an intact anesthetized rabbit model.

Journal: Polish journal of pharmacology 20030101

Title: [Effect of ATP-sensitive potassium channel modulators and intermittent hypoxia on mitochondrial respiration during stress].

Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20030101

Title: Improved myocardial function with the addition of pinacidil to custadiol.

Journal: Transplantation 20021227

Title: Smooth muscle membrane potential modulates endothelium-dependent relaxation of rat basilar artery via myo-endothelial gap junctions.

Journal: The Journal of physiology 20021215

Title: Developmental expression and functional significance of Kir channel subunits in ureteric bud and nephron epithelia.

Journal: Pflugers Archiv : European journal of physiology 20021201

Title: Properties of unitary potentials recorded from myenteric interstitial cells of Cajal distributed in the guinea-pig gastric antrum.

Journal: Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20021201

Title: The stereoenantiomers of a pinacidil analog open or close cloned ATP-sensitive K+ channels.

Journal: The Journal of biological chemistry 20021025

Title: Effect of diabetes on pinacidil-induced antinociception in mice.

Journal: European journal of pharmacology 20021025

Title: Ionic and cellular basis for the predominance of the Brugada syndrome phenotype in males.

Journal: Circulation 20021008

Title: Membrane potential controls calcium entry into descending vasa recta pericytes.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20021001

Title: Monolithic matrix type transdermal drug delivery systems of pinacidil monohydrate: in vitro characterisation.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20020901

Title: Opening of ATP-sensitive potassium channels causes generation of free radicals in vascular smooth muscle cells.

Journal: Basic research in cardiology 20020901

Title: Nitric oxide induces hyperpolarization by opening ATP-sensitive K(+) channels in guinea pig spiral modiolar artery.

Journal: Hearing research 20020901

Title: Molecular basis of ATP-sensitive K+ channels in rat vascular smooth muscles.

Journal: Biochemical and biophysical research communications 20020816

Title: Activation of adenosine triphosphate-sensitive potassium channels confers protection against rotenone-induced cell death: therapeutic implications for Parkinson's disease.

Journal: Journal of neuroscience research 20020815

Title: Alpha1-adrenoceptor-mediated breakdown of phosphatidylinositol 4,5-bisphosphate inhibits pinacidil-activated ATP-sensitive K+ currents in rat ventricular myocytes.

Journal: Circulation research 20020809

Title: Inhibitory effects of potassium channel blockers on tetramethylpyrazine-induced relaxation of rat aortic strip in vitro.

Journal: Life sciences 20020802

Title: K(ATP) channel-independent targets of diazoxide and 5-hydroxydecanoate in the heart.

Journal: The Journal of physiology 20020801

Title: The effects of drugs modulating K(+) transport on Rb(+) uptake and distribution in pig hearts following regional ischemia: (87)Rb MRI study.

Journal: NMR in biomedicine 20020801

Title: The role of myocardial KATP-channel blockade in the protective effects of glibenclamide against ischaemia in the rat heart.

Journal: Pharmacology & toxicology 20020801

Title: Potassium channels and human corporeal smooth muscle cell tone: diabetes and relaxation of human corpus cavernosum smooth muscle by adenosine triphosphate sensitive potassium channel openers.

Journal: The Journal of urology 20020701

Title: Mitochondrial K(ATP) channel openers activate the ERK kinase by an oxidant-dependent mechanism.

Journal: American journal of physiology. Cell physiology 20020701

Title: D2-like receptor-mediated inhibition of Na+-K+-ATPase activity is dependent on the opening of K+ channels.

Journal: American journal of physiology. Renal physiology 20020701

Title: Ketamine abolishes ischemic preconditioning through inhibition of K(ATP) channels in rabbit hearts.

Journal: American journal of physiology. Heart and circulatory physiology 20020701

Title: Hypoxic vasorelaxation inhibition by organ culture correlates with loss of Kv channels but not Ca(2+) channels.

Journal: American journal of physiology. Heart and circulatory physiology 20020701

Title: Differential modulation of the cardiac adenosine triphosphate-sensitive potassium channel by isoflurane and halothane.

Journal: Anesthesiology 20020701

Title: Effect of adenosine triphosphate-sensitive potassium channel openers on lung preservation.

Journal: American journal of respiratory and critical care medicine 20020601

Title: Inhaled pinacidil, an ATP-sensitive K+ channel opener, and moguisteine have potent antitussive effects in guinea pigs.

Journal: Japanese journal of pharmacology 20020601

Title: [New medications for treatment of erectile dysfunction].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20020601

Title: Vasorelaxing properties of some phenylacridine type potassium channel openers in isolated rabbit thoracic arteries.

Journal: European journal of medicinal chemistry 20020601

Title: Effect of 17beta-estradiol exposure on vasorelaxation induced by K(+) channel openers and Ca(2+) channel blockers.

Journal: Pharmacology 20020501

Title: Opening of mitochondrial ATP-sensitive potassium channels evokes oxygen radical generation in rabbit heart slices.

Journal: Journal of biochemistry 20020501

Title: Effects of K(ATP) channel modulators on acetylcholine release from guinea-pig isolated atria and small intestine.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20020501

Title: Isoflurane inhibits neutrophil-endothelium interactions in the coronary circulation: lack of a role for adenosine triphosphate-sensitive potassium channels.

Journal: Anesthesia and analgesia 20020401

Title: Effects of K(ATP) channel openers, P-1075, pinacidil, and diazoxide, on energetics and contractile function in isolated rat hearts.

Journal: Journal of molecular and cellular cardiology 20020401

Title: Nicorandil inhibits degranulation and TNF-alpha release from RBL-2H3 cells.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20020401

Title: Characterisation of the effects of potassium channel modulating agents on mouse intestinal smooth muscle.

Journal: The Journal of pharmacy and pharmacology 20020301

Title: Pharmacological evidence for the activation of K(+) channels by diclofenac.

Journal: European journal of pharmacology 20020301

Title: Cytochrome P450 3A4-mediated oxidative conversion of a cyano to an amide group in the metabolism of pinacidil.

Journal: Biochemistry 20020226

Title: Interactions of sildenafil with various coronary vasodilators in isolated porcine coronary artery.

Journal: European journal of pharmacology 20020222

Title: Diazoxide and pinacidil uncouple pyruvate-malate-induced mitochondrial respiration.

Journal: Journal of bioenergetics and biomembranes 20020201

Title: ATP-sensitive K(+) channels composed of Kir6.1 and SUR2B subunits in guinea pig gastric myocytes.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20020101

Title: Myocardial protection with pinacidil induced hyperpolarized arrest during cardiopulmonary bypass.

Journal: Chinese medical journal 20011201

Title: Myocardial protection of immature rabbits with an ATP-sensitive K+ channel opener pinacidil.

Journal: Chinese medical journal 20011101

Title: Dimethylsulfoxide and ethanol, commonly used diluents, prevent dilation of pial arterioles by openers of K(ATP) ion channels.

Journal: European journal of pharmacology 20011026

Title: Regulation of ATP-sensitive K(+) channels by protein kinase C in murine colonic myocytes.

Journal: American journal of physiology. Cell physiology 20010901

Title: Contribution of both the sarcolemmal K(ATP) and mitochondrial K(ATP) channels to infarct size limitation by K(ATP) channel openers: differences from preconditioning in the role of sarcolemmal K(ATP) channels.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20010901

Title: Gender-specific difference in cardiac ATP-sensitive K(+) channels.

Journal: Journal of the American College of Cardiology 20010901

Title: Antisense knockdown of inducible nitric oxide synthase inhibits the relaxant effect of VIP in isolated smooth muscle cells of the mouse gastric fundus.

Journal: British journal of pharmacology 20010901

Title: Sulfonylurea receptors inhibit the epithelial sodium channel (ENaC) by reducing surface expression.

Journal: Pflugers Archiv : European journal of physiology 20010801

Title: Comparison of the inhibitory effects of cromakalim and pinacidil (potassium channel openers) with those of oxybutynin on stimulated guinea pig and rabbit detrusor muscle strips.

Journal: Archives of gynecology and obstetrics 20010801

Title: Influence of ATP-sensitive K+ channel modulation on the mechanical properties of diabetic myocardium.

Journal: Endocrine research 20010801

Title: Adenosine activates ATP-sensitive K(+) currents in pericytes of rat retinal microvessels: role of A1 and A2a receptors.

Journal: Brain research 20010713

Title: Denervation enhances the physiological effects of the K(ATP) channel during fatigue in EDL and soleus muscle.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20010701

Title: Mitochondrial ATP-sensitive potassium channels inhibit apoptosis induced by oxidative stress in cardiac cells.

Journal: Circulation research 20010622

Title: Pinacidil prevents membrane depolarisation and intracellular Ca2+ loading in single cardiomyocytes exposed to severe metabolic stress.

Journal: International journal of molecular medicine 20010601

Title: K(ATP) channel currents regulate membrane potential in freshly isolated human and rat bladder smooth muscle cells.

Journal: Urology 20010601

Title: Changes in electrical properties of detrusor smooth muscle in the STZ (streptozotocin)-diabetic rat.

Journal: Urology 20010601

Title: Modulation of K+-evoked [3H]-noradrenaline release from rat and human brain slices by gabapentin: involvement of KATP channels.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20010501

Title: Vasorelaxing effect of the potassium (K+)-channel opener pinacidil in isolated porcine ciliary arteries.

Journal: Klinische Monatsblatter fur Augenheilkunde 20010501

Title: Delivery of genes encoding cardiac K(ATP) channel subunits in conjunction with pinacidil prevents membrane depolarization in cells exposed to chemical hypoxia-reoxygenation.

Journal: Biochemical and biophysical research communications 20010420

Title: Evidence for a K(ATP) ion channel link in the inhibition of hypercapnic dilation of pial arterioles by 7-nitroindazole and tetrodotoxin.

Journal: European journal of pharmacology 20010413

Title: ATP consumption by uncoupled mitochondria activates sarcolemmal K(ATP) channels in cardiac myocytes.

Journal: American journal of physiology. Heart and circulatory physiology 20010401

Title: Levosimendan increases diastolic coronary flow in isolated guinea-pig heart by opening ATP-sensitive potassium channels.

Journal: Journal of cardiovascular pharmacology 20010401

Title: Relaxant effects of 17-beta-estradiol in cerebral arteries through Ca(2+) entry inhibition.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20010401

Title: Functional roles of cardiac and vascular ATP-sensitive potassium channels clarified by Kir6.2-knockout mice.

Journal: Circulation research 20010330

Title: Functional implication of spare ATP-sensitive K(+) channels in bladder smooth muscle cells.

Journal: The Journal of pharmacology and experimental therapeutics 20010301

Title: ATP-sensitive K+ channels and cytoprotection.

Journal: Developmental medicine and child neurology. Supplement 20010301

Title: Activation of Na(+), K(+), Cl(-)-cotransport mediates intracellular Ca(2+) increase and apoptosis induced by Pinacidil in HepG2 human hepatoblastoma cells.

Journal: Biochemical and biophysical research communications 20010223

Title: Bioenergetic consequences of opening the ATP-sensitive K(+) channel of heart mitochondria.

Journal: American journal of physiology. Heart and circulatory physiology 20010201

Title: Pharmacological comparison of native mitochondrial K(ATP) channels with molecularly defined surface K(ATP) channels.

Journal: Molecular pharmacology 20010201

Title: Altered effects of potassium channel modulation in the coronary circulation in experimental hypercholesterolemia.

Journal: Atherosclerosis 20010201

Title: Effects of K+ channel openers on I K(ATP) of human atrial myocytes at physiological temperatures.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20010201

Title: Role of potassium channels in regulation of brain arteriolar tone: comparison of cerebrum versus brain stem.

Journal: Stroke 20010101

Title: A simple method to investigate the inhibitory effects of drugs on gastric emptying in the mouse in vivo.

Journal: Journal of pharmacological and toxicological methods 20010101

Title: Fluorescence-based functional assay for sarcolemmal ATP-sensitive potassium channel activation in cultured neonatal rat ventricular myocytes.

Journal: Journal of pharmacological and toxicological methods 20010101

Title: Hypotensive interaction of sildenafil and nicorandil in rats through the cGMP pathway but not by K(ATP) channel activation.

Journal: Japanese journal of pharmacology 20001101

Title: A KATP-channel opener as a potential treatment modality for erectile dysfunction.

Journal: BJU international 19990501

Title: Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel.

Journal: The Journal of physiology 19970315

Title: ATP-sensitive K+ channel opener pinacidil augments beta 1-adrenoceptor-induced coronary vasodilation in dogs.

Journal: The American journal of physiology 19960601

Title: K+ channel openers delay intestinal transit and have antidiarrheal activity.

Journal: European journal of pharmacology 19951212

Title: Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells.

Journal: The Journal of pharmacology and experimental therapeutics 19951101

Title: Effect of four potassium channel agonists on bupivacaine-induced toxicity in mice.

Journal: Life sciences 19950101

Title: Pinacidil-induced relaxation in pulmonary arteries isolated from pulmonary hypertensive and normotensive rats and pre-contracted with different spasmogens.

Journal: Pulmonary pharmacology 19941201

Title: Selective in vivo antagonism of pinacidil-induced hypotension by the guanidine U37883A in anesthetized rats.

Journal: Pharmacology 19941201

Title: Effects of pinacidil on guinea-pig isolated perfused heart with particular reference to the proarrhythmic effect.

Journal: British journal of pharmacology 19920301

Title: Effects of cromakalim and pinacidil on large epicardial and small coronary arteries in conscious dogs.

Journal: The Journal of pharmacology and experimental therapeutics 19901101

Title: Suppression of repolarization-related arrhythmias in vitro and in vivo by low-dose potassium channel activators.

Journal: Circulation 19901001

Title: The initial hemodynamic response to newer antihypertensive agents at rest and during exercise: review of visacor, doxazosin, nisoldipine, tiapamil, perindoprilat, pinacidil, dilevalol, and carvedilol.

Journal: Cardiovascular drugs and therapy 19900801

Title: Pinacidil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the treatment of hypertension.

Journal: Drugs 19900601

Title: Effects of pinacidil and cromakalim (BRL 34915) on bladder function in rats with detrusor instability.

Journal: The Journal of urology 19891001

Title: Comparative effects of nitroprusside and pinacidil on myocardial blood flow and infarct size in awake dogs with acute myocardial infarction.

Journal: Circulation 19880301

Title: Acute hemodynamic effects of pinacidil and hydralazine in essential hypertension.

Journal: Clinical pharmacology and therapeutics 19850301

Title: Suppression of ventricular arrhythmias after coronary artery ligation by pinacidil, a vasodilator drug.

Journal: Journal of cardiovascular pharmacology 19850101

Title: Systemic and coronary hemodynamic effects of pinacidil in awake normotensive and hypertensive dogs.

Journal: Hypertension (Dallas, Tex. : 1979) 19850101

Title: Vascular effects in dogs of pinacidil (P 1134), a novel vasoactive antihypertensive agent.

Journal: European journal of pharmacology 19830408

Title: Buckle DR, et al. Relaxant effects of the potassium channel activators BRL 38227 and pinacidil on guinea-pig and human airway smooth muscle, and blockade of their effects by glibenclamide and BRL 31660. Pulm Pharmacol. 1993 Mar;6(1):77-86.

Title: Bareggi SR, et al. Pharmacodynamics and pharmacokinetics of pinacidil in normotensive volunteers after repeated doses of a new slow-release tablet formulation. Arzneimittelforschung. 1999 Jan;49(1):21-5.

Title: Gollasch M, et al. Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells. J Pharmacol Exp Ther. 1995 Nov;275(2):681-92.

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Tags:85371-64-8 Molecular Formula|85371-64-8 MDL|85371-64-8 SMILES|85371-64-8 Guanidine,N-cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)-, hydrate (1:1)