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85539-83-9,MFCD00948748
Catalog No.:AA004UOC

85539-83-9 | p-Xyleneselenocyanate

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100mg
≥99%
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$236.00   $165.00
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250mg
≥99%
in stock  
$432.00   $303.00
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500mg
≥99%
in stock  
$704.00   $493.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA004UOC
Chemical Name:
p-Xyleneselenocyanate
CAS Number:
85539-83-9
Molecular Formula:
C10H8N2Se2
Molecular Weight:
314.1039
MDL Number:
MFCD00948748
SMILES:
N#C[Se]Cc1ccc(cc1)C[Se]C#N
Properties
Computed Properties
 
Complexity:
224  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
2  
Rotatable Bond Count:
4  

Literature

Title: Remarkable inhibition of mTOR signaling by the combination of rapamycin and 1,4-phenylenebis(methylene)selenocyanate in human prostate cancer cells.

Journal: International journal of cancer 20121101

Title: Induction of lung glutathione and glutamylcysteine ligase by 1,4-phenylenebis(methylene)selenocyanate and its glutathione conjugate: role of nuclear factor-erythroid 2-related factor 2.

Journal: Free radical biology & medicine 20120515

Title: Spectral modification and catalytic inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2A6, and 2A13 by four chemopreventive organoselenium compounds.

Journal: Chemical research in toxicology 20110815

Title: Down-regulation of 14-3-3 isoforms and annexin A5 proteins in lung adenocarcinoma induced by the tobacco-specific nitrosamine NNK in the A/J mouse revealed by proteomic analysis.

Journal: Journal of proteome research 20090801

Title: Modulations of benzo[a]pyrene-induced DNA adduct, cyclin D1 and PCNA in oral tissue by 1,4-phenylenebis(methylene)selenocyanate.

Journal: Biochemical and biophysical research communications 20090522

Title: Effects of naturally occurring and synthetic organoselenium compounds on protein profiling in androgen responsive and androgen independent human prostate cancer cells.

Journal: Nutrition and cancer 20080101

Title: Effects of 1,4-phenylenebis(methylene)selenocyanate on mutagenesis and p53 protein expression in the tongue of lacI rats treated with 4-nitroquinoline-N-oxide.

Journal: Mutation research 20071201

Title: Inhibition of nuclear factor-kappaB DNA binding by organoselenocyanates through covalent modification of the p50 subunit.

Journal: Cancer research 20071101

Title: Differential effects of naturally occurring and synthetic organoselenium compounds on biomarkers in androgen responsive and androgen independent human prostate carcinoma cells.

Journal: International journal of cancer 20070401

Title: Molecular targets of the chemopreventive agent 1,4-phenylenebis (methylene)-selenocyanate in human non-small cell lung cancer.

Journal: Carcinogenesis 20060701

Title: The organoselenium compound 1,4-phenylenebis(methylene)selenocyanate inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced tumorgenesis and enhances glutathione-related antioxidant levels in A/J mouse lung.

Journal: Chemico-biological interactions 20060610

Title: Vitamin E and organoselenium prevent the cocarcinogenic activity of arsenite with solar UVR in mouse skin.

Journal: Carcinogenesis 20051201

Title: Comparative excretion and tissue distribution of selenium in mice and rats following treatment with the chemopreventive agent 1,4-phenylenebis(methylene)selenocyanate.

Journal: Chemico-biological interactions 20050210

Title: Effects of a combination of docosahexaenoic acid and 1,4-phenylene bis(methylene) selenocyanate on cyclooxygenase 2, inducible nitric oxide synthase and beta-catenin pathways in colon cancer cells.

Journal: Carcinogenesis 20041201

Title: Effects of 3H-1,2-dithiole-3-thione, 1,4-phenylenebis(methylene)selenocyanate, and selenium-enriched yeast individually and in combination on benzo[a]pyrene-induced mutagenesis in oral tissue and esophagus in lacZ mice.

Journal: Mutation research 20040411

Title: Antiproliferative effect of 1,4-phenylenebis(methylene)selenocyanate (p-XSC) on colonic epithelium of patients with adenomatous polyps in vitro.

Journal: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20031201

Title: Comparative action of 1,4-phenylenebis(methylene)selenocyanate and its metabolites against 7,12-dimethylbenz[a]anthracene-DNA adduct formation in the rat and cell proliferation in rat mammary tumor cells.

Journal: Chemico-biological interactions 20031025

Title: Elucidation of molecular targets of mammary cancer chemoprevention in the rat by organoselenium compounds using cDNA microarray.

Journal: Carcinogenesis 20030901

Title: Characteristics of selenazolidine prodrugs of selenocysteine: toxicity and glutathione peroxidase induction in V79 cells.

Journal: Journal of medicinal chemistry 20030717

Title: Comparison of the chemopreventive efficacies of 1,4-phenylenebis(methylene)selenocyanate and selenium-enriched yeast on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced lung tumorigenesis in A/J mouse.

Journal: Nutrition and cancer 20030101

Title: Effects of 1,4-phenylenebis(methylene)selenocyanate (p-XSC) and vitamin E on 4-nitroquinoline-N-oxide (4-NQO)-induced mutagenesis in lacZ mouse upper aerodigestive tissue.

Journal: Mutation research 20020627

Title: Cyclooxygenase-2 expression influences the growth of human large and small cell lung carcinoma lines in athymic mice: impact of an organoselenium compound on growth regulation.

Journal: International journal of oncology 20020301

Title: Expression of cyclin D1/2 in the lungs of strain A/J mice fed chemopreventive agents.

Journal: Carcinogenesis 20020201

Title: Induction of apoptosis by 1,4-phenylenebis(methylene)selenocyanate in cultured human colon cancer cells.

Journal: Anticancer research 20020101

Title: Enhanced sensitivity of human oral carcinomas to induction of apoptosis by selenium compounds: involvement of mitogen-activated protein kinase and Fas pathways.

Journal: Cancer research 20011015

Title: Chemoprevention of colon cancer by a glutathione conjugate of 1,4-phenylenebis(methylene)selenocyanate, a novel organoselenium compound with low toxicity.

Journal: Cancer research 20010501

Title: Mechanisms of organoselenium compounds in chemoprevention: effects on transcription factor-DNA binding.

Journal: Nutrition and cancer 20010101

Title: Molecular mechanisms of cancer prevention by selenium compounds.

Journal: Nutrition and cancer 20010101

Title: Chemoprevention of familial adenomatous polyposis development in the APC(min) mouse model by 1,4-phenylene bis(methylene)selenocyanate.

Journal: Carcinogenesis 20000401

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