Home Other Building Blocks 857290-04-1
857290-04-1,MFCD12828758
Catalog No.:AA004P27

857290-04-1 | Pf-915275

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5mg
≥98%(HPLC)
in stock  
$257.00   $180.00
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10mg
≥98%(HPLC)
in stock  
$365.00   $255.00
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25mg
≥98%(HPLC)
in stock  
$749.00   $524.00
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50mg
≥98%(HPLC)
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$1,329.00   $930.00
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100mg
≥98%(HPLC)
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$2,345.00   $1,642.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA004P27
Chemical Name:
Pf-915275
CAS Number:
857290-04-1
Molecular Formula:
C18H14N4O2S
Molecular Weight:
350.3944
MDL Number:
MFCD12828758
SMILES:
N#Cc1ccc(cc1)c1ccc(cc1)S(=O)(=O)Nc1cccc(n1)N
Properties
Properties
 
Form:
Solid  

Computed Properties
 
Complexity:
578  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
2.7  

Literature

Title: Cortisol and interferon tau regulation of endometrial function and conceptus development in female sheep.

Journal: Endocrinology 20130201

Title: Will treating diabetes with 11β-HSD1 inhibitors affect the HPA axis?

Journal: Trends in endocrinology and metabolism: TEM 20101001

Title: Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model.

Journal: Journal of medicinal chemistry 20090910

Title: N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275.

Journal: Bioorganic & medicinal chemistry letters 20090701

Title: Blockade of glucocorticoid excess at the tissue level: inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 as a therapy for type 2 diabetes.

Journal: Journal of medicinal chemistry 20080828

Title: Modulation of 11beta-hydroxysteroid dehydrogenase (11betaHSD) activity biomarkers and pharmacokinetics of PF-00915275, a selective 11betaHSD1 inhibitor.

Journal: The Journal of clinical endocrinology and metabolism 20080201

Title: Demonstration of proof of mechanism and pharmacokinetics and pharmacodynamic relationship with 4'-cyano-biphenyl-4-sulfonic acid (6-amino-pyridin-2-yl)-amide (PF-915275), an inhibitor of 11 -hydroxysteroid dehydrogenase type 1, in cynomolgus monkeys.

Journal: The Journal of pharmacology and experimental therapeutics 20080101

Title: Induction of 11β-HSD 1 and activation of distinct mineralocorticoid receptor- and glucocorticoid receptor-dependent gene networks in decidualizing human endometrial stromal cells.

Journal: Molecular endocrinology (Baltimore, Md.)

Title: Bhat BG, et al. Demonstration of proof of mechanism and pharmacokinetics and pharmacodynamic relationship with 4'-cyano-biphenyl-4-sulfonic acid (6-amino-pyridin-2-yl)-amide (PF-915275), an inhibitor of 11 -hydroxysteroid dehydrogenase type 1, in cynomolgus monkeys. J Pharmacol Exp Ther. 2008 Jan;324(1):299-305.

Title: Siu M, et al. N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3493-7.

Title: Courtney R, et al. Modulation of 11beta-hydroxysteroid dehydrogenase (11betaHSD) activity biomarkers and pharmacokinetics of PF-00915275, a selective 11betaHSD1 inhibitor. J Clin Endocrinol Metab. 2008 Feb;93(2):550-6.

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