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857876-30-3,MFCD12407403
Catalog No.:AA00G2I5

857876-30-3 | Motesanib diphosphate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$63.00   $44.00
- +
5mg
≥98%
in stock  
$129.00   $90.00
- +
10mg
in stock  
$151.00   $106.00
- +
50mg
≥98%
in stock  
$429.00   $300.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00G2I5
Chemical Name:
Motesanib diphosphate
CAS Number:
857876-30-3
Molecular Formula:
C22H29N5O9P2
Molecular Weight:
569.4413
MDL Number:
MFCD12407403
SMILES:
OP(=O)(O)O.OP(=O)(O)O.O=C(c1cccnc1NCc1ccncc1)Nc1ccc2c(c1)NCC2(C)C
Properties
Computed Properties
 
Complexity:
583  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
38  
Hydrogen Bond Acceptor Count:
13  
Hydrogen Bond Donor Count:
9  
Rotatable Bond Count:
5  

Downstream Synthesis Route

[1]CurrentPatentAssignee:AMGENINC-WO2007/92178,2007,A1Locationinpatent:Page/Pagecolumn24-25

[1]CurrentPatentAssignee:AMGENINC-WO2007/92178,2007,A1Locationinpatent:Page/Pagecolumn23-24

Literature

Title: Polverino A, et al. AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts. Cancer Res. 2006 Sep 1;66(17):8715-21.

Title: Kruser TJ, et al. Augmentation of radiation response by motesanib, a multikinase inhibitor that targets vascular endothelial growth factor receptors. Clin Cancer Res, 2010, 16(14), 3639-3647.

Title: Coxon A, et al. Broad antitumor activity in breast cancer xenografts by motesanib, a highly selective, oral inhibitor of vascular endothelial growth factor, platelet-derived growth factor, and Kit receptors. Clin Cancer Res, 2009, 15(1), 110-118.

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SDS
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