Home Quinolines 86-95-3
86-95-3,MFCD00006744
Catalog No.:AA004HJ5

86-95-3 | 2,4-Dihydroxyquinoline

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5g
97%
in stock  
$14.00   $10.00
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25g
98%(HPLC)
in stock  
$35.00   $25.00
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100g
97%
in stock  
$67.00   $47.00
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500g
97%
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$308.00   $216.00
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA004HJ5
Chemical Name:
2,4-Dihydroxyquinoline
CAS Number:
86-95-3
Molecular Formula:
C9H7NO2
Molecular Weight:
161.1574
MDL Number:
MFCD00006744
SMILES:
O=c1cc(O)c2c([nH]1)cccc2
Properties
Properties
 
BP:
303.8 °C at 760 mmHg  
Form:
Solid  
MP:
>300 °C(lit.);  
Refractive Index:
1.5050 (estimate)  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
235  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
XLogP3:
0.7  

Literature

Title: Design, synthesis and antitubercular potency of 4-hydroxyquinolin-2(1H)-ones.

Journal: European journal of medicinal chemistry 20170929

Title: Quorum sensing modulates colony morphology through alkyl quinolones in Pseudomonas aeruginosa.

Journal: BMC microbiology 20120101

Title: Honey's Ability to Counter Bacterial Infections Arises from Both Bactericidal Compounds and QS Inhibition.

Journal: Frontiers in microbiology 20120101

Title: Pseudomonas aeruginosa overrides the virulence inducing effect of opioids when it senses an abundance of phosphate.

Journal: PloS one 20120101

Title: Synthesis and biotransformation of 2-alkyl-4(1H)-quinolones by recombinant Pseudomonas putida KT2440.

Journal: Applied microbiology and biotechnology 20110901

Title: A quorum sensing regulated small volatile molecule reduces acute virulence and promotes chronic infection phenotypes.

Journal: PLoS pathogens 20110801

Title: Quinolones: from antibiotics to autoinducers.

Journal: FEMS microbiology reviews 20110301

Title: Electrochemically induced multicomponent assembling of isatins, 4-hydroxyquinolin-2(1H)-one and malononitrile: a convenient and efficient way to functionalized spirocyclic [indole-3,4'-pyrano[3,2-c]quinoline] scaffold.

Journal: Molecular diversity 20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Transcriptomic analysis reveals a global alkyl-quinolone-independent regulatory role for PqsE in facilitating the environmental adaptation of Pseudomonas aeruginosa to plant and animal hosts.

Journal: Environmental microbiology 20100601

Title: Homeostatic interplay between bacterial cell-cell signaling and iron in virulence.

Journal: PLoS pathogens 20100301

Title: Structure of PqsD, a Pseudomonas quinolone signal biosynthetic enzyme, in complex with anthranilate.

Journal: Biochemistry 20090915

Title: Development of N-[11C]methylamino 4-hydroxy-2(1H)-quinolone derivatives as PET radioligands for the glycine-binding site of NMDA receptors.

Journal: Bioorganic & medicinal chemistry 20090801

Title: Ring-substituted 4-hydroxy-1H-quinolin-2-ones: preparation and biological activity.

Journal: Molecules (Basel, Switzerland) 20090313

Title: Design and synthesis of 5-alkoxy-[1,2,4]triazolo[4,3-a]quinoline derivatives with anticonvulsant activity.

Journal: European journal of medicinal chemistry 20090301

Title: PqsD is responsible for the synthesis of 2,4-dihydroxyquinoline, an extracellular metabolite produced by Pseudomonas aeruginosa.

Journal: The Journal of biological chemistry 20081024

Title: Pseudomonas aeruginosa suppresses host immunity by activating the DAF-2 insulin-like signaling pathway in Caenorhabditis elegans.

Journal: PLoS pathogens 20081001

Title: A liquid chromatography-quadrupole time-of-flight (LC-QTOF)-based metabolomic approach reveals new metabolic effects of catechin in rats fed high-fat diets.

Journal: Journal of proteome research 20080601

Title: PqsA is required for the biosynthesis of 2,4-dihydroxyquinoline (DHQ), a newly identified metabolite produced by Pseudomonas aeruginosa and Burkholderia thailandensis.

Journal: Biological chemistry 20070801

Title: Microwave prompted multigram synthesis, structural determination, and photo-antiproliferative activity of fluorinated 4-hydroxyquinolinones.

Journal: Bioorganic & medicinal chemistry letters 20070101

Title: Studies on parasitologic and haematologic activities of an enaminone derivative of 4-hydroxyquinolin-2(1H)-one against murine schistosomiasis mansoni.

Journal: MedGenMed : Medscape general medicine 20070101

Title: Diversity-oriented synthesis of functionalized quinolin-2(1H)-ones via Pd-catalyzed site-selective cross-coupling reactions.

Journal: Journal of combinatorial chemistry 20070101

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Synthesis and SAR of highly potent and selective dopamine D(3)-receptor antagonists: Quinolin(di)one and benzazepin(di)one derivatives. [email protected].

Journal: Bioorganic & medicinal chemistry letters 20060201

Title: Synthesis of 4-hydroxycoumarin and 2,4-quinolinediol derivatives and evaluation of their effects on the viability of HepG2 cells and human hepatocytes culture.

Journal: European journal of medicinal chemistry 20041101

Title: CoMFA and homology-based models of the glycine binding site of N-methyl-d-aspartate receptor.

Journal: Journal of medicinal chemistry 20030424

Title: Synthesis and antibacterial activity of 2-substituted 6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids.

Journal: Farmaco (Societa chimica italiana : 1989) 20010901

Title: 4-Hydroxy-6-oxo-6,7-dihydro-thieno[2,3-b] pyrimidine derivatives: synthesis and their biological evaluation for the glycine site acting on the N-methyl-D-aspartate (NMDA) receptor.

Journal: Archives of pharmacal research 20010801

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Tags:86-95-3 Molecular Formula|86-95-3 MDL|86-95-3 SMILES|86-95-3 2,4-Dihydroxyquinoline |Organic_Building_Blocks