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861393-28-4,MFCD09970333
Catalog No.:AA0036AJ

861393-28-4 | A-740003

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Purity
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1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
≥98%
in stock  
$166.00   $116.00
- +
10mg
≥98%
in stock  
$219.00   $153.00
- +
50mg
≥98%
in stock  
$220.00   $154.00
- +
100mg
≥98%
in stock  
$322.00   $225.00
- +
250mg
≥98%
in stock  
$654.00   $458.00
- +
500mg
≥98%
in stock  
$1,129.00   $790.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0036AJ
Chemical Name:
A-740003
CAS Number:
861393-28-4
Molecular Formula:
C26H30N6O3
Molecular Weight:
474.5548
MDL Number:
MFCD09970333
SMILES:
N#CNC(=NC(C(C)(C)C)NC(=O)Cc1ccc(c(c1)OC)OC)Nc1cccc2c1cccn2
Properties
Properties
 
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
773  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
10  
Undefined Atom Stereocenter Count:
1  
XLogP3:
4.6  

Literature

Title: P2X7R activation drives distinct IL-1 responses in dendritic cells compared to macrophages.

Journal: Cytokine 20150801

Title: Assessment of mercury chloride-induced toxicity and the relevance of P2X7 receptor activation in zebrafish larvae.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20130901

Title: P2X7 receptor activation ameliorates CA3 neuronal damage via a tumor necrosis factor-α-mediated pathway in the rat hippocampus following status epilepticus.

Journal: Journal of neuroinflammation 20110101

Title: Novel P2X7 receptor antagonists ease the pain.

Journal: British journal of pharmacology 20070701

Title: A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat.

Journal: The Journal of pharmacology and experimental therapeutics 20061201

Title: The conformational oscillation of delta-chymotrypsin involvement of methionine-192.

Journal: European journal of biochemistry 19751101

Title: Grol MW, et al. P2X?-mediated calcium influx triggers a sustained, PI3K-dependent increase in metabolic acid production by osteoblast-like cells. Am J Physiol Endocrinol Metab. 2012 Mar 1;302(5):E561-75.

Title: Kim JE, et al. P2X7 receptor activation ameliorates CA3 neuronal damage via a tumor necrosis factor-α-mediated pathway in the rat hippocampus following status epilepticus. J Neuroinflammation. 2011 Jun 2;8:62.

Title: Donnelly-Roberts DL, et al. Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors.Br J Pharmacol. 2009 Aug;157(7):1203-14. Epub 2009 Jun 22.

Title: Honore P, et al. A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methylamino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide, a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat. J Pharmacol Exp Ther. 2006 Dec;319(3):1376-85. Epub 2006 Sep 18.

Title: Y. H. Gao, et al. Effect of electroacupuncture on the cervicospinal P2X7 receptor/fractalkine/CX3CR1 signaling pathway in a rat neck-incision pain model. Purinergic Signal. 2017 Jun;13(2):215-225. 

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