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864070-44-0,MFCD22566222
Catalog No.:AA0039NP

864070-44-0 | (2S,3R,4R,5S,6R)-2-[4-chloro-3-({4-[(3S)-oxolan-3-yloxy]phenyl}methyl)phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol

Pack Size
Purity
Availability
Price(USD)
Quantity
  
10mg
98%
in stock  
$6.00   $4.00
- +
50mg
98%
in stock  
$7.00   $5.00
- +
250mg
98%
in stock  
$17.00   $12.00
- +
1g
98%
in stock  
$56.00   $39.00
- +
5g
98%
in stock  
$100.00   $70.00
- +
10g
98%
in stock  
$160.00   $112.00
- +
25g
98%
in stock  
$328.00   $230.00
- +
100g
98%
in stock  
$880.00   $616.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0039NP
Chemical Name:
(2S,3R,4R,5S,6R)-2-[4-chloro-3-({4-[(3S)-oxolan-3-yloxy]phenyl}methyl)phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol
CAS Number:
864070-44-0
Molecular Formula:
C23H27ClO7
Molecular Weight:
450.9093
MDL Number:
MFCD22566222
SMILES:
OC[C@H]1O[C@@H](c2ccc(c(c2)Cc2ccc(cc2)O[C@@H]2COCC2)Cl)[C@@H]([C@H]([C@@H]1O)O)O
Properties
Computed Properties
 
Complexity:
558  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
6  
XLogP3:
2  

Downstream Synthesis Route

[1]CurrentPatentAssignee:HANGZHOUPUSHAIPHARMACEUTICALTECHNOLOGYCOLTD(unclear)-CN105384730,2016,ALocationinpatent:Paragraph0075;0076

[2]CurrentPatentAssignee:C.H.BoehringerSohnAG&Co.KG-WO2006/117359,2006,A1Locationinpatent:Page/Pagecolumn17

[3]CurrentPatentAssignee:C.H.BoehringerSohnAG&Co.KG-US2007/249544,2007,A1Locationinpatent:Page/Pagecolumn6

[4]CurrentPatentAssignee:ZYDUSLIFESCIENCESLTD-US2017/247356,2017,A1Locationinpatent:Paragraph0170;0193;0194

[5]CurrentPatentAssignee:DRREDDY'SLABORATORIESLIMITED-WO2017/203457,2017,A1Locationinpatent:Page/Pagecolumn42-44

[1]CurrentPatentAssignee:C.H.BoehringerSohnAG&Co.KG-US2006/258749,2006,A1Locationinpatent:Page/Pagecolumn29-30

[2]CurrentPatentAssignee:LUPINLIMITED-WO2017/141202,2017,A1

[3]CurrentPatentAssignee:HANSOHPHARMACEUTICALGROUPCOLTD-CN106336403,2017,A

864070-44-0    108-24-7   
(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-trityltriacetate 

[1]CurrentPatentAssignee:C.H.BoehringerSohnAG&Co.KG-WO2007/93610,2007,A1Locationinpatent:Page/Pagecolumn42

[1]CurrentPatentAssignee:YANGTZERIVERPHARMACEUTICALGROUPCOLTD-CN110407891,2019,ALocationinpatent:Paragraph0043-0048

[2]CurrentPatentAssignee:JIANGSUCOLLEGEOFENGINEERINGANDTECHNOLOGY-CN107652276,2018,ALocationinpatent:Paragraph0015;0021

[3]CurrentPatentAssignee:JIANGSUCOLLEGEOFENGINEERINGANDTECHNOLOGY-CN107652277,2018,ALocationinpatent:Paragraph0022

[4]CurrentPatentAssignee:C.H.BoehringerSohnAG&Co.KG-WO2011/39107,2011,A1Locationinpatent:Page/Pagecolumn21-23

[5]CurrentPatentAssignee:JIANGSUCOLLEGEOFENGINEERINGANDTECHNOLOGY-CN107652278,2018,ALocationinpatent:Paragraph0022

[6]CurrentPatentAssignee:BEIJINGWINSUNNYPHARMACEUTICAL-CN105481915,2016,ALocationinpatent:Paragraph0035;0036

[7]Wang,Xiao-Jun;Zhang,Li;Byrne,Denis;Nummy,Larry;Weber,Dirk;Krishnamurthy,Dhileep;Yee,Nathan;Senanayake,ChrisH.[OrganicLetters,2014,vol.16,#16,p.4090-4093]

[8]CurrentPatentAssignee:ANHUIJIUHUAHUAYUANPHARMACEUTICAL-CN106632288,2017,ALocationinpatent:Paragraph0076;0077;0078;0079;0080

[9]Peng,Peng;Zhao,Chuanmeng;Yang,Jiangtao;Liu,Xiao;Yu,Jun;Zhang,Fuli[OrganicPreparationsandProceduresInternational,2022,vol.54,#3,p.203-219]

[10]CurrentPatentAssignee:THEKALYANIGROUP-WO2021/250565,2021,A1Locationinpatent:Page/Pagecolumn4;9-11

[11]CurrentPatentAssignee:YANGTZERIVERPHARMACEUTICALGROUPCOLTD-CN107163033,2017,ALocationinpatent:Paragraph0035;0036

[12]CurrentPatentAssignee:SHANGHAIFOSUNPHARMACEUTICAL(GROUP)CO.,LTD.-CN109988161,2019,ALocationinpatent:Paragraph0067-0073

[13]CurrentPatentAssignee:JIANGSUDEYUANPHARMCOLTD-CN114380775,2022,ALocationinpatent:Paragraph0061-0068

[1]CurrentPatentAssignee:C.H.BoehringerSohnAG&Co.KG-US2011/237789,2011,A1

[2]CurrentPatentAssignee:C.H.BoehringerSohnAG&Co.KG-US2011/237526,2011,A1

[3]CurrentPatentAssignee:JIANGSUCOLLEGEOFENGINEERINGANDTECHNOLOGY-CN107652276,2018,A

[4]CurrentPatentAssignee:JIANGSUCOLLEGEOFENGINEERINGANDTECHNOLOGY-CN107652277,2018,A

Literature

Title: Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes.

Journal: The New England journal of medicine 20151126

Title: Pharmacokinetics, Pharmacodynamics and Clinical Use of SGLT2 Inhibitors in Patients with Type 2 Diabetes Mellitus and Chronic Kidney Disease.

Journal: Clinical pharmacokinetics 20150701

Title: Empagliflozin for the treatment of type 2 diabetes.

Journal: Expert opinion on pharmacotherapy 20141101

Title: Empagliflozin (Jardiance) for diabetes.

Journal: The Medical letter on drugs and therapeutics 20141013

Title: Efficacy and safety of empagliflozin for type 2 diabetes: a systematic review and meta-analysis.

Journal: Diabetes, obesity & metabolism 20141001

Title: Empagliflozin as add-on to metformin in patients with type 2 diabetes: a 24-week, randomized, double-blind, placebo-controlled trial.

Journal: Diabetes care 20140601

Title: Empagliflozin, a sodium glucose co-transporter 2 inhibitor, in the treatment of type 1 diabetes.

Journal: Expert opinion on investigational drugs 20140601

Title: Empagliflozin for the treatment of Type 2 diabetes.

Journal: Expert review of clinical pharmacology 20140501

Title: Empagliflozin: a new sodium-glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes.

Journal: Drugs in context 20140101

Title: Nonclinical safety of the sodium-glucose cotransporter 2 inhibitor empagliflozin.

Journal: International journal of toxicology 20140101

Title: Pharmacokinetics of empagliflozin, a sodium glucose cotransporter-2 (SGLT-2) inhibitor, coadministered with sitagliptin in healthy volunteers.

Journal: Advances in therapy 20121001

Title: Empagliflozin, a novel potent and selective SGLT-2 inhibitor, improves glycaemic control alone and in combination with insulin in streptozotocin-induced diabetic rats, a model of type 1 diabetes mellitus.

Journal: Diabetes, obesity & metabolism 20120701

Title: A novel approach to control hyperglycemia in type 2 diabetes: sodium glucose co-transport (SGLT) inhibitors: systematic review and meta-analysis of randomized trials.

Journal: Annals of medicine 20120601

Title: [New possibility in the oral glucose lowering treatment of type 2 diabetes mellitus: sodium-glucose co-transporter-2 inhibitors].

Journal: Orvosi hetilap 20120506

Title: Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors.

Journal: Diabetes, obesity & metabolism 20120101

Title: Long-term treatment with empagliflozin, a novel, potent and selective SGLT-2 inhibitor, improves glycaemic control and features of metabolic syndrome in diabetic rats.

Journal: Diabetes, obesity & metabolism 20120101

Title: Sodium glucose cotransporter 2 inhibitors as a new treatment for diabetes mellitus.

Journal: The Journal of clinical endocrinology and metabolism 20100101

Title: From victim to ally: the kidney as an emerging target for the treatment of diabetes mellitus.

Journal: Current medical research and opinion 20090301

Title: Inhibition of renal glucose reabsorption: a novel strategy for achieving glucose control in type 2 diabetes mellitus.

Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20080901

Title: Grempler R, et al. Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors. Diabetes Obes Metab. 2012 Jan;14(1):83-90.

Title: Cheng ST, et al. The Effects of Empagliflozin, an SGLT2 Inhibitor, on Pancreatic β-Cell Mass and Glucose Homeostasis in Type 1 Diabetes. PLoS One. 2016 Jan 25;11(1):e0147391.

Title: Nikole J.ByrneBSc, et al. Empagliflozin Prevents Worsening of Cardiac Function in an Experimental Model of Pressure Overload-Induced Heart Failure. JACC Basic Transl Sci. 2017 Aug;2(4):347-354.

Title: Sakaeda T, et al. Susceptibility to serious skin and subcutaneous tissue disorders and skin tissue distribution of sodium-dependent glucose co-transporter type 2 (SGLT2) inhibitors. Int J Med Sci. 2018 Jun 13;15(9):937-943.

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Tags:864070-44-0 Molecular Formula|864070-44-0 MDL|864070-44-0 SMILES|864070-44-0 (2S,3R,4R,5S,6R)-2-[4-chloro-3-({4-[(3S)-oxolan-3-yloxy]phenyl}methyl)phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol