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Home Fluorides 864864-17-5
864864-17-5,MFCD17167018
Catalog No.:AA0038ZB

864864-17-5 | 2-cyclopropyl-5-[1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-2,3-dihydro-1H-isoindol-1-one

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Purity
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Price(USD)
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5mg
≥90%
in stock  
$145.00   $101.00
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10mg
≥90%
in stock  
$260.00   $182.00
- +
25mg
≥90%
in stock  
$542.00   $379.00
- +
50mg
≥90%
in stock  
$939.00   $657.00
- +
  • Technical Information
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA0038ZB
Chemical Name:
2-cyclopropyl-5-[1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-2,3-dihydro-1H-isoindol-1-one
CAS Number:
864864-17-5
Molecular Formula:
C19H16FN5O
Molecular Weight:
349.3616
MDL Number:
MFCD17167018
SMILES:
O=C1N(Cc2c1ccc(c2)c1nnn(c1C)c1cccnc1F)C1CC1
Properties
Computed Properties
 
Complexity:
558  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
5  
Rotatable Bond Count:
3  
XLogP3:
2.4  

Literature

Title: Pharmacological effects of metabotropic glutamate receptor ligands on prepulse inhibition in DBA/2J mice.

Journal: European journal of pharmacology 20100810

Title: Effect of CFMTI, an allosteric metabotropic glutamate receptor 1 antagonist with antipsychotic activity, on Fos expression in regions of the brain related to schizophrenia.

Journal: Neuroscience 20100714

Title: Discovery and biological profile of isoindolinone derivatives as novel metabotropic glutamate receptor 1 antagonists: a potential treatment for psychotic disorders.

Journal: Bioorganic & medicinal chemistry letters 20090915

Title: Unique antipsychotic activities of the selective metabotropic glutamate receptor 1 allosteric antagonist 2-cyclopropyl-5-[1-(2-fluoro-3-pyridinyl)-5-methyl-1H-1,2,3-triazol-4-yl]-2,3-dihydro-1H-isoindol-1-one.

Journal: The Journal of pharmacology and experimental therapeutics 20090701

Title: Satow A et al. Unique antipsychotic activities of the selective metabotropic glutamate receptor 1 allosteric antagonist 2-cyclopropyl-5--(2-fluoro-3-pyridinyl)-5-methyl-1H-1,2,3-triazol-4-yl-2,3-dihydro-1H-isoindol-1-one. J Pharmacol Exp Ther. 2009 Jul;330(1):179-90.

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Tags:864864-17-5 Molecular Formula|864864-17-5 MDL|864864-17-5 SMILES|864864-17-5 2-cyclopropyl-5-[1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-2,3-dihydro-1H-isoindol-1-one