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Home Amines 865305-30-2
865305-30-2,MFCD18782750
Catalog No.:AA00369N

865305-30-2 | 2,4-Pyrimidinediamine, 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
1 week  
$13.00   $9.00
- +
25mg
98+%
1 week  
$125.00   $88.00
- +
50mg
98+%
1 week  
$210.00   $147.00
- +
100mg
98+%
1 week  
$357.00   $250.00
- +
250mg
98+%
1 week  
$606.00   $424.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00369N
Chemical Name:
2,4-Pyrimidinediamine, 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-
CAS Number:
865305-30-2
Molecular Formula:
C14H17IN4O2
Molecular Weight:
400.2149
MDL Number:
MFCD18782750
SMILES:
COc1cc(C(C)C)c(cc1I)Oc1cnc(nc1N)N
Properties
Properties
 
Form:
Solid  

Computed Properties
 
Complexity:
334  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
2.8  

Downstream Synthesis Route
865305-30-2    13331-23-2   
5-(5-Furan-2-yl-2-isopropyl-4-methoxy-phenoxy)-pyrimidine-2,4-diamine 

[1]CurrentPatentAssignee:ROCHEHOLDINGAG-US2005/209260,2005,A1Locationinpatent:Page/Pagecolumn137

[2]CurrentPatentAssignee:ROCHEHOLDINGAG-US2007/49609,2007,A1Locationinpatent:Page/Pagecolumn118

288-32-4    865305-30-2   
5-(5-imidazol-1-yl-2-isopropyl-4-methoxy-phenoxy)-pyrimidine-2,4-diamine 

[1]CurrentPatentAssignee:ROCHEHOLDINGAG-US2005/209260,2005,A1Locationinpatent:Page/Pagecolumn105

[2]CurrentPatentAssignee:ROCHEHOLDINGAG-US2007/49609,2007,A1Locationinpatent:Page/Pagecolumn96

288-47-1    865305-30-2   
5-(5-Furan-2-yl-2-isopropyl-4-methoxy-phenoxy)-pyrimidine-2,4-diamine 

[1]CurrentPatentAssignee:ROCHEHOLDINGAG-US2005/209260,2005,A1Locationinpatent:Page/Pagecolumn137

288-47-1    865305-30-2   
5-(2-isopropyl-4-methoxy-5-thiazol-5-yl-phenoxy)-pyrimidine-2,4-diamine 

[1]CurrentPatentAssignee:ROCHEHOLDINGAG-US2005/209260,2005,A1Locationinpatent:Page/Pagecolumn122

[1]CurrentPatentAssignee:ROCHEHOLDINGAG-US2005/209260,2005,A1Locationinpatent:Page/Pagecolumn95-96

[2]CurrentPatentAssignee:ROCHEHOLDINGAG-US2007/49609,2007,A1Locationinpatent:Page/Pagecolumn87-88

[3]CurrentPatentAssignee:MERCK&COINC-US2015/57299,2015,A1Locationinpatent:Paragraph0155;0156

[4]CurrentPatentAssignee:MERCK&COINC-WO2016/4358,2016,A1Locationinpatent:Paragraph185

[5]CurrentPatentAssignee:ROCHEHOLDINGAG-US2007/49758,2007,A1Locationinpatent:Page/Pagecolumn31-32

[6]CurrentPatentAssignee:ROCHEHOLDINGAG-US2007/49751,2007,A1Locationinpatent:Page/Pagecolumn19-21

Literature

Title: AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist.

Journal: British journal of pharmacology 20100701

Title: Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X(3)/P2X(2/3) antagonist for the treatment of pain.

Journal: Bioorganic & medicinal chemistry letters 20090315

Title: Identification and SAR of novel diaminopyrimidines. Part 1: The discovery of RO-4, a dual P2X(3)/P2X(2/3) antagonist for the treatment of pain.

Journal: Bioorganic & medicinal chemistry letters 20090315

Title: Gever JR, et al. AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. Br J Pharmacol. 2010 Jul;160(6):1387-1398.

Title: Munoz A, et al. Modulation of bladder afferent signals in normal and spinal cord-injured rats by purinergic P2X3 and P2X2/3receptors. BJU Int. 2012 Oct;110(8 Pt B):E409-414.

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Tags:865305-30-2 Molecular Formula|865305-30-2 MDL|865305-30-2 SMILES|865305-30-2 2,4-Pyrimidinediamine, 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-