Home Other Building Blocks 865362-74-9
865362-74-9,MFCD14585805
Catalog No.:AA004PPG

865362-74-9 | Fr 180204

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Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$41.00   $29.00
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5mg
98%
in stock  
$102.00   $71.00
- +
10mg
98%
in stock  
$187.00   $131.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA004PPG
Chemical Name:
Fr 180204
CAS Number:
865362-74-9
Molecular Formula:
C18H13N7
Molecular Weight:
327.3427
MDL Number:
MFCD14585805
SMILES:
Nc1[nH]nc2c1cc(nn2)c1c(nn2c1cccc2)c1ccccc1
Properties
Properties
 
Form:
Solid  
Storage:
Light sensitive;Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
468  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  
XLogP3:
1.9  

Literature

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: Efficacy of the novel dual PI3-kinase/mTOR inhibitor NVP-BEZ235 in a preclinical model of adrenocortical carcinoma.

Journal: Molecular and cellular endocrinology 20121125

Title: Differential ubiquitylation of the mineralocorticoid receptor is regulated by phosphorylation.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20121001

Title: Transforming growth factor β and Ras/MEK/ERK signaling regulate the expression level of a novel tumor suppressor Lefty.

Journal: Pancreas 20120701

Title: Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A.

Journal: Journal of molecular and cellular cardiology 20111201

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111101

Title: Molecular cloning and characterization of mitogen-activated protein kinase 2 in Toxoplasma gondii.

Journal: Cell cycle (Georgetown, Tex.) 20111015

Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20071218

Title: FR180204, a novel and selective inhibitor of extracellular signal-regulated kinase, ameliorates collagen-induced arthritis in mice.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20070101

Title: Crystal structure of human ERK2 complexed with a pyrazolo[3,4-c]pyridazine derivative.

Journal: Bioorganic & medicinal chemistry letters 20060101

Title: Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex.

Journal: Biochemical and biophysical research communications 20051014

Title: Ohori M, et al. Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex. Biochem Biophys Res Commun. 2005 Oct 14;336(1):357-63.

Title: Ohori M, et al. FR180204, a novel and selective inhibitor of extracellular signal-regulated kinase, ameliorates collagen-induced arthritis in mice. Naunyn Schmiedebergs Arch Pharmacol. 2007 Jan;374(4):311-6.

Title: Honda M, et al. Mesothelioma cell proliferation through autocrine activation of PDGF-ββ receptor. Cell Physiol Biochem. 2012;29(5-6):667-74

Title: Sreekanth GP, et al. Role of ERK1/2 signaling in dengue virus-induced liver injury. Virus Res. 2014 Aug 8;188:15-26

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