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865466-24-6,MFCD16038932
Catalog No.:AA00GU26

865466-24-6 | Narlaprevir

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
95%
1 week  
$558.00   $391.00
- +
10mg
95%
1 week  
$860.00   $602.00
- +
50mg
95%
1 week  
$1,384.00   $969.00
- +
100mg
95%
1 week  
$1,955.00   $1,369.00
- +
  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00GU26
Chemical Name:
Narlaprevir
CAS Number:
865466-24-6
Molecular Formula:
C36H61N5O7S
Molecular Weight:
707.9638
MDL Number:
MFCD16038932
SMILES:
CCCCC(C(=O)C(=O)NC1CC1)NC(=O)C1N(CC2C1C2(C)C)C(=O)C(C(C)(C)C)NC(=O)NC1(CCCCC1)CS(=O)(=O)C(C)(C)C
Properties
Computed Properties
 
Complexity:
1400  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Heavy Atom Count:
49  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
15  
XLogP3:
5.4  

Literature

Title: Antiviral activity of narlaprevir combined with ritonavir and pegylated interferon in chronic hepatitis C patients.

Journal: Hepatology (Baltimore, Md.) 20101101

Title: Preclinical characterization of the antiviral activity of SCH 900518 (narlaprevir), a novel mechanism-based inhibitor of hepatitis C virus NS3 protease.

Journal: Antimicrobial agents and chemotherapy 20100601

Title: Ashok Arasappan, et al. Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor. ACS Med Chem Lett. 2010 Feb 15;1(2):64-9.

Title: X Tong, et al. Preclinical characterization of the antiviral activity of SCH 900518 (narlaprevir), a novel mechanism-based inhibitor of hepatitis C virus NS3 protease. Antimicrob Agents Chemother. 2010 Jun;54(6):2365-70.

Title: Qi Sun, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May 29;6(1):212.

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SDS
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