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865854-05-3,MFCD18633296
Catalog No.:AA00362O

865854-05-3 | Tideglusib

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$7.00   $5.00
- +
10mg
98%
in stock  
$11.00   $8.00
- +
50mg
98%
in stock  
$24.00   $17.00
- +
100mg
98%
in stock  
$38.00   $27.00
- +
250mg
98%
in stock  
$63.00   $44.00
- +
1g
98%
in stock  
$170.00   $119.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00362O
Chemical Name:
Tideglusib
CAS Number:
865854-05-3
Molecular Formula:
C19H14N2O2S
Molecular Weight:
334.3917
MDL Number:
MFCD18633296
SMILES:
O=c1sn(c(=O)n1Cc1ccccc1)c1cccc2c1cccc2
Properties
Properties
 
BP:
511.3±43.0°C at 760 mmHg  
Form:
Solid  
MP:
148 - 150ºC  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
492  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
3  
Rotatable Bond Count:
3  
XLogP3:
4.3  

Literature

Title: Promotion of natural tooth repair by small molecule GSK3 antagonists.

Journal: Scientific reports 20170101

Title: Treatment of Alzheimer's disease with the GSK-3 inhibitor tideglusib: a pilot study.

Journal: Journal of Alzheimer's disease : JAD 20130101

Title: Evidence for irreversible inhibition of glycogen synthase kinase-3β by tideglusib.

Journal: The Journal of biological chemistry 20120106

Title: Exploring the binding sites of glycogen synthase kinase 3. Identification and characterization of allosteric modulation cavities.

Journal: Journal of medicinal chemistry 20111222

Title: Switching reversibility to irreversibility in glycogen synthase kinase 3 inhibitors: clues for specific design of new compounds.

Journal: Journal of medicinal chemistry 20110623

Title: Glycogen synthase kinase 3 inhibitors in the next horizon for Alzheimer's disease treatment.

Journal: International journal of Alzheimer's disease 20110101

Title: A novel GSK-3beta inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo.

Journal: Neurobiology of disease 20090901

Title: NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: potential therapeutic role in brain disorders.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20070523

Title: Domínguez JM, et al. Evidence for irreversible inhibition of glycogen synthase kinase-3β by tideglusib. J Biol Chem, 2012, 287(2), 893-90

Title: Luna-Medina R, et al. NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: potential therapeutic role in brain disorders. J Neurosci, 2007, 27(21), 5766-5776.

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SDS
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