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866206-54-4,MFCD20488005
Catalog No.:AA00GU2Y

866206-54-4 | PRX-08066

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$37.00   $26.00
- +
5mg
98+%
in stock  
$91.00   $64.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00GU2Y
Chemical Name:
PRX-08066
CAS Number:
866206-54-4
Molecular Formula:
C19H17ClFN5S
Molecular Weight:
401.8882
MDL Number:
MFCD20488005
SMILES:
N#Cc1cc(ccc1F)CN1CCC(CC1)Nc1ncnc2c1cc(s2)Cl
Properties
Computed Properties
 
Complexity:
552  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
4.7  

Upstream Synthesis Route

[1]Patent:US2005/222175,2005,A1,

[2]Patent:US2005/222176,2005,A1,

Downstream Synthesis Route
6-chloro-N-(piperidin-4-yl)thieno2,3-dpyrimidin-4-aminedihydrochloride 
  218301-22-5    866206-54-4    866206-62-4 

[1]Patent:US2005/222175,2005,A1

[2]Patent:US2005/222176,2005,A1

Literature

Title: PRX-08066, a novel 5-hydroxytryptamine receptor 2B antagonist, reduces monocrotaline-induced pulmonary arterial hypertension and right ventricular hypertrophy in rats.

Journal: The Journal of pharmacology and experimental therapeutics 20100801

Title: A new class of 5-HT2B antagonists possesses favorable potency, selectivity, and rat pharmacokinetic properties.

Journal: Bioorganic & medicinal chemistry letters 20090415

Title: Transfer of gases and metabolites in the equine placenta: a comparison with other species.

Journal: Journal of reproduction and fertility. Supplement 19751001

Title: Porvasnik SL, et al. PRX-08066, a novel 5-hydroxytryptamine receptor 2B antagonist, reduces monocrotaline-induced pulmonary arterial hypertension and right ventricular hypertrophy in rats. J Pharmacol Exp Ther. 2010 Aug;334(2):364-72.

Title: Svejda B, et al. The 5-HT(2B) receptor plays a key regulatory role in both neuroendocrine tumor cell proliferation and the modulation of the fibroblast component of the neoplastic microenvironment. Cancer. 2010 Jun 15;116(12):2902-12.

Title: Warburton R.R., et al. Online University.

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SDS
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Tags:866206-54-4 Molecular Formula|866206-54-4 MDL|866206-54-4 SMILES|866206-54-4 PRX-08066
Catalog No.: AA00GU2Y
866206-54-4,MFCD20488005
866206-54-4 | PRX-08066
Pack Size： 1mg
Purity： 98+%
in stock
$37.00 $26.00
Pack Size： 5mg
Purity： 98+%
in stock
$91.00 $64.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00GU2Y
Chemical Name: PRX-08066
CAS Number: 866206-54-4
Molecular Formula: C19H17ClFN5S
Molecular Weight: 401.8882
MDL Number: MFCD20488005
SMILES: N#Cc1cc(ccc1F)CN1CCC(CC1)Nc1ncnc2c1cc(s2)Cl
Properties
Complexity: 552  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 27  
Hydrogen Bond Acceptor Count: 7  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 4  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 4.7  
Upstream Synthesis Route
218301-22-5    866206-54-4    866206-62-4 

[1]Patent:US2005/222175,2005,A1,

[2]Patent:US2005/222176,2005,A1,

Downstream Synthesis Route
6-chloro-N-(piperidin-4-yl)thieno2,3-dpyrimidin-4-aminedihydrochloride 
  218301-22-5    866206-54-4    866206-62-4 

[1]Patent:US2005/222175,2005,A1

[2]Patent:US2005/222176,2005,A1

Literature fold

Title: PRX-08066, a novel 5-hydroxytryptamine receptor 2B antagonist, reduces monocrotaline-induced pulmonary arterial hypertension and right ventricular hypertrophy in rats.

Journal: The Journal of pharmacology and experimental therapeutics20100801

Title: A new class of 5-HT2B antagonists possesses favorable potency, selectivity, and rat pharmacokinetic properties.

Journal: Bioorganic & medicinal chemistry letters20090415

Title: Transfer of gases and metabolites in the equine placenta: a comparison with other species.

Journal: Journal of reproduction and fertility. Supplement19751001

Title: Porvasnik SL, et al. PRX-08066, a novel 5-hydroxytryptamine receptor 2B antagonist, reduces monocrotaline-induced pulmonary arterial hypertension and right ventricular hypertrophy in rats. J Pharmacol Exp Ther. 2010 Aug;334(2):364-72.

Title: Svejda B, et al. The 5-HT(2B) receptor plays a key regulatory role in both neuroendocrine tumor cell proliferation and the modulation of the fibroblast component of the neoplastic microenvironment. Cancer. 2010 Jun 15;116(12):2902-12.

Title: Warburton R.R., et al. Online University.

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