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869477-96-3,MFCD28369297
Catalog No.:AA01CBSQ

869477-96-3 | Olodaterol Hydrochloride

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$182.00   $128.00
- +
5mg
98%
in stock  
$322.00   $225.00
- +
10mg
98%
in stock  
$499.00   $349.00
- +
25mg
98%
in stock  
$852.00   $597.00
- +
100mg
98%
in stock  
$2,620.00   $1,834.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01CBSQ
Chemical Name:
Olodaterol Hydrochloride
CAS Number:
869477-96-3
Molecular Formula:
C21H27ClN2O5
Molecular Weight:
422.9025
MDL Number:
MFCD28369297
SMILES:
COc1ccc(cc1)CC(NC[C@@H](c1cc(O)cc2c1OCC(=O)N2)O)(C)C.Cl
Properties
Computed Properties
 
Complexity:
521  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
7  

Literature

Title: Olodaterol: a review of its use in chronic obstructive pulmonary disease.

Journal: Drugs 20150401

Title: Dual regulation of β2-adrenoceptor messenger RNA expression in human lung fibroblasts by β2-cAMP signaling; delayed upregulated inhibitors oppose a rapid in onset, direct stimulation of gene expression.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20140101

Title: Lung function efficacy and symptomatic benefit of olodaterol once daily delivered via Respimat® versus placebo and formoterol twice daily in patients with GOLD 2-4 COPD: results from two replicate 48-week studies.

Journal: International journal of chronic obstructive pulmonary disease 20140101

Title: Olodaterol: first global approval.

Journal: Drugs 20131101

Title: Endothelin-1 enhances β₂-adrenoceptor gene transcription in human lung fibroblasts.

Journal: Life sciences 20121015

Title: β₂-adrenoceptors and muscarinic receptors mediate opposing effects on endothelin-1 expression in human lung fibroblasts.

Journal: European journal of pharmacology 20120915

Title: β₂ long-acting and anticholinergic drugs control TGF-β1-mediated neutrophilic inflammation in COPD.

Journal: Biochimica et biophysica acta 20120701

Title: Functional and biochemical rationales for the 24-hour-long duration of action of olodaterol.

Journal: The Journal of pharmacology and experimental therapeutics 20110601

Title: Pharmacological characterization of olodaterol, a novel inhaled beta2-adrenoceptor agonist exerting a 24-hour-long duration of action in preclinical models.

Journal: The Journal of pharmacology and experimental therapeutics 20100701

Title: Discovery of olodaterol, a novel inhaled beta2-adrenoceptor agonist with a 24 h bronchodilatory efficacy.

Journal: Bioorganic & medicinal chemistry letters 20100215

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