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869998-49-2,MFCD09265259
Catalog No.:AA00GT8Y

869998-49-2 | SPD-304

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$80.00   $56.00
- +
5mg
≥98%
in stock  
$322.00   $225.00
- +
10mg
≥98%
in stock  
$560.00   $392.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00GT8Y
Chemical Name:
SPD-304
CAS Number:
869998-49-2
Molecular Formula:
C32H32F3N3O2
Molecular Weight:
547.6106
MDL Number:
MFCD09265259
SMILES:
CN(Cc1cn(c2c1cccc2)c1cccc(c1)C(F)(F)F)CCN(Cc1coc2c(c1=O)cc(c(c2)C)C)C
Properties
Computed Properties
 
Complexity:
910  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
40  
Hydrogen Bond Acceptor Count:
7  
Rotatable Bond Count:
8  
XLogP3:
6.3  

Literature

Title: Molly M. He, et al. Small-Molecule Inhibition of TNF-α. Science 11 Nov 2005.

Title: Alexiou P, et al. Rationally designed less toxic SPD-304 analogs and preliminary evaluation of their TNF inhibitory effects. Arch Pharm (Weinheim). 2014 Nov;347(11):798-805.

Title: Mouhsine H, et al. Identification of an in vivo orally active dual-binding protein-protein interaction inhibitor targeting TNFα through combined in silico/in vitro/in vivo screening. Sci Rep. 2017 Jun 13;7(1):3424.

Title: Gallic acid induces necroptosis via TNF-α signaling pathway in activated hepatic stellate cells. Chang YJ, et al. PLoS One. 2015 Mar 27;10(3):e0120713.

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SDS
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Tags:869998-49-2 Molecular Formula|869998-49-2 MDL|869998-49-2 SMILES|869998-49-2 SPD-304