Name: Name:5-Bromoisatin
Brand: AABLOCKS
SKU: AA003MHF
Rating: 90 (10 reviews)

5-Bromoisatin serves as a versatile building block in organic synthesis, enabling the preparation of various derivatives and compounds. It is commonly utilized in the synthesis of N-derivatives of 5-bromoisatin, N-substituted pyrroles, linear polyaryleneoxindoles, 5-bromodioxindole, cinchoninic acid derivatives, 3-hydroxyoxindole, S-benzyldithiocarbazate Schiff Bases, and 5-bromooxindole. These compounds find applications in diverse areas such as pharmaceuticals, materials science, and organic chemistry.

Catalog No.: AA003MHF

87-48-9 | 5-Bromoisatin

Pack Size： 1g

Purity： 98%

in stock

$6.00 $4.00

Pack Size： 5g

Purity： 98%

in stock

$7.00 $5.00

Pack Size： 10g

Purity： 98%

in stock

$10.00 $7.00

Pack Size： 25g

Purity： 98%

in stock

$21.00 $15.00

Pack Size： 100g

Purity： 98%

in stock

$70.00 $49.00

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Technical Information

Catalog Number: AA003MHF

Chemical Name: 5-Bromoisatin

CAS Number: 87-48-9

Molecular Formula: C8H4BrNO2

Molecular Weight: 226.0269

MDL Number: MFCD00005719

SMILES: Brc1ccc2c(c1)C(=O)C(=O)N2

NSC Number: 4980

Properties

Form: Solid

MP: 251-253 °C

Refractive Index: 1.6120 (estimate)

Solubility: Soluble in N,N dimethylformamide.

Storage: Keep in dry area;Room Temperature;

Complexity: 241

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 12

Hydrogen Bond Acceptor Count: 2

Hydrogen Bond Donor Count: 1

Isotope Atom Count: 0

Rotatable Bond Count: 0

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 1.3

105:

Upstream Synthesis Route

87-48-9

1077-94-7

[1]TetrahedronLetters,2007,vol.48,#14,p.2457-2460

[2]Patent:WO2006/101456,2006,A1,.Locationinpatent:Page/Pagecolumn54-55

[3]Patent:WO2005/63767,2005,A2,.Locationinpatent:Page/Pagecolumn39-40

[4]Patent:WO2006/69097,2006,A2,.Locationinpatent:Page/Pagecolumn37

[5]Patent:WO2004/29050,2004,A1,.Locationinpatent:Page74

[6]Patent:EP2565192,2013,A1,.Locationinpatent:Paragraph0363

87-48-9

877-42-9

[1]JournaloftheChemicalSociety,1948,p.106,108

[2]JournaloftheChemicalSociety,1948,p.106,108

1113-59-3

87-48-9

552330-94-6

[1]BioorganicandMedicinalChemistryLetters,2006,vol.16,#7,p.2000-2007

[2]Patent:WO2011/87837,2011,A2,.Locationinpatent:Page/Pagecolumn30-31

[3]Patent:WO2012/87372,2012,A1,.Locationinpatent:Page/Pagecolumn30-31

87-48-9

552330-94-6

[1]JournalofOrganicChemistry,1953,vol.18,p.552,553

87-48-9

74-88-4

20870-90-0

[1]Chemistry-AnAsianJournal,2017,vol.12,#7,p.734-743

Downstream Synthesis Route

3350-30-9

87-48-9

2-bromo-7,8,9,10,11,12-hexahydro-6<i>H</i>-cyclonona<i>b</i>quinoline-13-carboxylicacid

[1]BulletindelaSocieteChimiquedeFrance,1958,p.1567

26673-32-5

87-48-9

672287-58-0

[1]JournaloftheChemicalSociety,1952,p.279

2700-47-2

87-48-9

6-bromo-2-(6-methoxy-2naphthyl)-3-methyl-quinoline-4-carboxylicacid

[1]RecueildesTravauxChimiquesdesPays-Bas,1949,vol.68,p.781,785

347-84-2

87-48-9

361-28-4

[1]RecueildesTravauxChimiquesdesPays-Bas,1949,vol.68,p.781,785

2001-29-8

87-48-9

6-bromo-2-(4-bromo-phenyl)-3-phenyl-quinoline-4-carboxylicacid

[1]JournalofOrganicChemistry,1953,vol.18,p.1209,1219

Literature fold

Title: 5-Bromo-1-(prop-2-en-1-yl)-2,3-dihydro-1H-indole-2,3-dione.

Journal: Acta crystallographica. Section E, Structure reports online20120101

Title: Synthesis and anticancer activity of isatin-based pyrazolines and thiazolidines conjugates.

Journal: Archiv der Pharmazie20110801

Title: 1-(5-Bromo-2-oxoindolin-3-yl-idene)thio-semicarbazide acetonitrile monosolvate.

Journal: Acta crystallographica. Section E, Structure reports online20110701

Title: Synthesis characterization and biological activity study of new schiff and mannich bases and some metal complexes derived from isatin and dithiooxamide.

Journal: Bioinorganic chemistry and applications20110101

Title: QSAR study of isatin analogues as in vitro anti-cancer agents.

Journal: European journal of medicinal chemistry20100301

Title: Investigation of trypanothione reductase as a drug target in Trypanosoma brucei.

Journal: ChemMedChem20091207

Title: Design, Synthesis and antiHIV activity of Novel Isatine-Sulphonamides.

Journal: Indian journal of pharmaceutical sciences20080101

Title: Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.

Journal: Journal of medicinal chemistry20070419

Title: In vitro cytotoxicity evaluation of some substituted isatin derivatives.

Journal: Bioorganic & medicinal chemistry20070115

Title: Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain.

Journal: Bioorganic & medicinal chemistry letters20031020

Application fold

5-Bromoisatin serves as a versatile building block in organic synthesis, enabling the preparation of various derivatives and compounds. It is commonly utilized in the synthesis of N-derivatives of 5-bromoisatin, N-substituted pyrroles, linear polyaryleneoxindoles, 5-bromodioxindole, cinchoninic acid derivatives, 3-hydroxyoxindole, S-benzyldithiocarbazate Schiff Bases, and 5-bromooxindole. These compounds find applications in diverse areas such as pharmaceuticals, materials science, and organic chemistry.