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87-64-9,MFCD00020000
Catalog No.:AA003365

87-64-9 | 2-Chloro-6-methylphenol

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250mg
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1g
95%
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$22.00   $15.00
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5g
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  • Technical Information
  • Properties
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003365
Chemical Name:
2-Chloro-6-methylphenol
CAS Number:
87-64-9
Molecular Formula:
C7H7ClO
Molecular Weight:
142.5829
MDL Number:
MFCD00020000
SMILES:
Oc1c(C)cccc1Cl
NSC Number:
2878
Properties
Properties
 
BP:
75-76°C at 12 mmHg  
Form:
Solid  
MP:
130℃  
Refractive Index:
1.545  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
94.9  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
9  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
XLogP3:
2.8  

Literature

Title: Molecular structure, spectroscopic studies (FTIR, FT-Raman and NMR) and HOMO-LUMO analysis of 6-chloro-o-cresol and 4-chloro-3-methyl phenol by density functional theoretical study.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20121101

Title: Control of Giardia infections with ronidazole and intensive hygiene management in a dog kennel.

Journal: Veterinary parasitology 20120608

Title: Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.

Journal: The Journal of investigative dermatology 20120101

Title: The antioxidant N-acetylcysteine prevents the mitochondrial fragmentation induced by soluble amyloid-β peptide oligomers.

Journal: Neuro-degenerative diseases 20120101

Title: Technological study of preparing gel from semi-solid extract of Cacalia hastata L.

Journal: Journal of advanced pharmaceutical technology & research 20120101

Title: Infection dynamics of Ascaridia galli in non-caged laying hens.

Journal: Veterinary parasitology 20110825

Title: Alterations of excitation-contraction coupling and excitation coupled Ca(2+) entry in human myotubes carrying CAV3 mutations linked to rippling muscle.

Journal: Human mutation 20110301

Title: Analysis of human cultured myotubes responses mediated by ryanodine receptor 1.

Journal: Anaesthesia and intensive care 20110301

Title: A heterogeneous Fenton-like system with nanoparticulate zero-valent iron for removal of 4-chloro-3-methyl phenol.

Journal: Journal of hazardous materials 20110215

Title: Combined moxidectin and environmental therapy do not eliminate Chorioptes bovis infestation in heavily feathered horses.

Journal: Veterinary dermatology 20110201

Title: Role of glycogen availability in sarcoplasmic reticulum Ca2+ kinetics in human skeletal muscle.

Journal: The Journal of physiology 20110201

Title: Evaluation of commonly-used farm disinfectants in wet and dry models of Salmonella farm contamination.

Journal: Avian pathology : journal of the W.V.P.A 20110201

Title: Potential dermal wound healing agent in Blechnum orientale Linn.

Journal: BMC complementary and alternative medicine 20110101

Title: Use of antimony in the treatment of leishmaniasis: current status and future directions.

Journal: Molecular biology international 20110101

Title: Role of cAMP Signaling in the Survival and Infectivity of the Protozoan Parasite, Leishmania donovani.

Journal: Molecular biology international 20110101

Title: Antimony resistance in leishmania, focusing on experimental research.

Journal: Journal of tropical medicine 20110101

Title: S100A1 promotes action potential-initiated calcium release flux and force production in skeletal muscle.

Journal: American journal of physiology. Cell physiology 20101101

Title: Quantitative measurement of Ca²(+) in the sarcoplasmic reticulum lumen of mammalian skeletal muscle.

Journal: Biophysical journal 20101020

Title: Development and validation of a stability-indicating RP-HPLC method for simultaneous assay of betamethasone dipropionate, chlorocresol, and for the estimation of betamethasone dipropionate related compounds in a pharmaceutical cream and ointment.

Journal: Journal of chromatographic science 20101001

Title: Determination of phenolic disinfectants in consumer products by capillary electrophoresis with amperometric detection.

Journal: Journal of chromatographic science 20100801

Title: Sarcoplasmic reticulum Ca2+ depletion in adult skeletal muscle fibres measured with the biosensor D1ER.

Journal: Pflugers Archiv : European journal of physiology 20100401

Title: Mechanism of the anodic oxidation of 4-chloro-3-methyl phenol in aqueous solution using Ti/SnO2-Sb/PbO2 electrodes.

Journal: Journal of hazardous materials 20100315

Title: A ryanodine receptor agonist promotes the consolidation of long-term memory in young chicks.

Journal: Behavioural brain research 20100105

Title: In vitro dermal penetration of 4-chloro-3-methylphenol from commercial metal working fluid and aqueous vehicles.

Journal: Journal of toxicology and environmental health. Part A 20100101

Title: UVB photolysis of betamethasone and its esters: characterization of photoproducts in solution, in pig skin and in drug formulations.

Journal: Journal of photochemistry and photobiology. B, Biology 20090717

Title: An improved primary human nasal cell culture for the simultaneous determination of transepithelial transport and ciliary beat frequency.

Journal: The Journal of pharmacy and pharmacology 20090701

Title: Co-metabolism of 2,4-dichlorophenol and 4-Cl-m-cresol in the presence of glucose as an easily assimilated carbon source by Staphylococcus xylosus.

Journal: Journal of hazardous materials 20090415

Title: Increasing the number of diagnostic mutations in malignant hyperthermia.

Journal: Human mutation 20090401

Title: Functional characterization of ryanodine receptor (RYR1) sequence variants using a metabolic assay in immortalized B-lymphocytes.

Journal: Human mutation 20090401

Title: Functional ryanodine receptors in the plasma membrane of RINm5F pancreatic beta-cells.

Journal: The Journal of biological chemistry 20090220

Title: A simple RP-HPLC method for the simultaneous quantitation of chlorocresol, mometasone furoate, and fusidic acid in creams.

Journal: Journal of chromatographic science 20090201

Title: Commonly used ryanodine receptor activator, 4-chloro-m-cresol (4CmC), is also an inhibitor of SERCA Ca2+ pumps.

Journal: Pharmacological reports : PR 20090101

Title: A new two-phase dimeticone pediculicide shows high efficacy in a comparative bioassay.

Journal: BMC dermatology 20090101

Title: Novel ryanodine receptor mutation that may cause malignant hyperthermia.

Journal: Anesthesiology 20080901

Title: Ryanodine receptor expression correlates with tumor grade in breast cancer.

Journal: Pathology oncology research : POR 20080601

Title: Different involvement of type 1, 2, and 3 ryanodine receptors in memory processes.

Journal: Learning & memory (Cold Spring Harbor, N.Y.) 20080501

Title: Effect of mitochondria poisoning by FCCP on Ca2+ signaling in mouse skeletal muscle fibers.

Journal: Pflugers Archiv : European journal of physiology 20080101

Title: Reduction of quaternary ammonium-induced ocular surface toxicity by emulsions: an in vivo study in rabbits.

Journal: Molecular vision 20080101

Title: Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.

Journal: Journal of vascular research 20080101

Title: [Disturbances in the function of cardiomyocyte ryanodine receptors of spontaneously hypertensive rats revealed by 4-chloro-m-cresol].

Journal: Biofizika 20080101

Title: Allergic contact dermatitis mimicking mammary paget's disease.

Journal: Indian journal of dermatology 20080101

Title: Identification of functional type 1 ryanodine receptors in human dendritic cells.

Journal: Biochemical and biophysical research communications 20071019

Title: Caffeine-activated large-conductance plasma membrane cation channels in cardiac myocytes: characteristics and significance.

Journal: American journal of physiology. Heart and circulatory physiology 20071001

Title: 4-Chloro-m-cresol, an activator of ryanodine receptors, inhibits voltage-gated K(+) channels at the rat calyx of Held.

Journal: The European journal of neuroscience 20070901

Title: Malignant hyperthermia associated with diabetic hyperosmolar hyperglycemic nonketotic state in a young man.

Journal: Journal of clinical anesthesia 20070901

Title: Functional ryanodine receptors are expressed by human microglia and THP-1 cells: Their possible involvement in modulation of neurotoxicity.

Journal: Journal of neuroscience research 20070801

Title: Centronuclear myopathy due to a de novo dominant mutation in the skeletal muscle ryanodine receptor (RYR1) gene.

Journal: Neuromuscular disorders : NMD 20070401

Title: Malignant hyperthermia.

Journal: Orphanet journal of rare diseases 20070101

Title: Ca2+ store determines gating of store operated calcium entry in mammalian skeletal muscle.

Journal: Journal of muscle research and cell motility 20070101

Title: Severe adverse cutaneous reaction to insulin due to cresol sensitivity.

Journal: Contact dermatitis 20060801

Title: Amino acid residues Gln4020 and Lys4021 of the ryanodine receptor type 1 are required for activation by 4-chloro-m-cresol.

Journal: The Journal of biological chemistry 20060728

Title: Structural determinants of 4-chloro-m-cresol required for activation of ryanodine receptor type 1.

Journal: Molecular pharmacology 20060701

Title: Characterization of ryanodine receptor-mediated calcium release in human B cells: relevance to diagnostic testing for malignant hyperthermia.

Journal: Anesthesiology 20060601

Title: Oxidation of myosin heavy chain and reduction in force production in hyperthyroid rat soleus.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20060501

Title: Can 4-chloro-m-cresol be substituted for caffeine as an activator of calcium oscillation in bullfrog sympathetic ganglion cells?

Journal: Cell calcium 20060501

Title: Functional properties of ryanodine receptors carrying three amino acid substitutions identified in patients affected by multi-minicore disease and central core disease, expressed in immortalized lymphocytes.

Journal: The Biochemical journal 20060415

Title: Effects of caffeine, halothane, and 4-chloro-m-cresol on skeletal muscle lactate and pyruvate in malignant hyperthermia-susceptible and normal swine as assessed by microdialysis.

Journal: Anesthesiology 20060101

Title: [Effects of agonists and antagonists of rhyanodine receptors on potassium contractures in twitch and tonic frog skeletal muscle fibers].

Journal: Biofizika 20060101

Title: Non-specific effects of 4-chloro-m-cresol may cause calcium flux and respiratory burst in human neutrophils.

Journal: Biochemical and biophysical research communications 20051104

Title: Contact sensitivity to preservatives in Turkey.

Journal: Contact dermatitis 20050601

Title: High-speed digital imaging method for ciliary beat frequency measurement.

Journal: The Journal of pharmacy and pharmacology 20050401

Title: Stable ciliary activity in human nasal epithelial cells grown in a perfusion system.

Journal: International journal of pharmaceutics 20050323

Title: Enhanced response to caffeine and 4-chloro-m-cresol in malignant hyperthermia-susceptible muscle is related in part to chronically elevated resting [Ca2+]i.

Journal: American journal of physiology. Cell physiology 20050301

Title: 3,5-di-t-butylcatechol (DTCAT) as an activator of rat skeletal muscle ryanodine receptor Ca2+ channel (RyRC).

Journal: Biochemical pharmacology 20050201

Title: Mutational analysis of putative calcium binding motifs within the skeletal ryanodine receptor isoform, RyR1.

Journal: The Journal of biological chemistry 20041217

Title: Contact urticaria due to p-chloro-m-cresol.

Journal: The British journal of dermatology 20041001

Title: Functional characterization of malignant hyperthermia-associated RyR1 mutations in exon 44, using the human myotube model.

Journal: Neuromuscular disorders : NMD 20040701

Title: 4-chloro-m-cresol cannot detect malignant hyperthermia equivocal cells in an alternative minimally invasive diagnostic test of malignant hyperthermia susceptibility.

Journal: Anesthesia and analgesia 20040701

Title: [Contact sensitization to pharmaceutic aids in dermatologic cosmetic and external use preparations].

Journal: Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20040501

Title: Influence of intracellular Ca2+ release modulating drugs on bupivacaine infiltration anesthesia in mice.

Journal: European journal of pain (London, England) 20040401

Title: Ryanodine receptor mutations associated with stress-induced ventricular tachycardia mediate increased calcium release in stimulated cardiomyocytes.

Journal: Circulation research 20030919

Title: Allergenicity evaluation of p-chloro-m-cresol and p-chloro-m-xylenol by non-radioactive murine local lymph-node assay and multiple-dose guinea pig maximization test.

Journal: Toxicology 20030828

Title: Dysregulated ryanodine receptors mediate cellular toxicity: restoration of normal phenotype by FKBP12.6.

Journal: The Journal of biological chemistry 20030801

Title: Identification of a key determinant of ryanodine receptor type 1 required for activation by 4-chloro-m-cresol.

Journal: The Journal of biological chemistry 20030801

Title: The Ile2453Thr mutation in the ryanodine receptor gene 1 is associated with facilitated calcium release from sarcoplasmic reticulum by 4-chloro-m-cresol in human myotubes.

Journal: Cell calcium 20030801

Title: Ca(2+)-induced Ca(2+) release in the pancreatic beta-cell: direct evidence of endoplasmic reticulum Ca(2+) release.

Journal: Endocrinology 20030801

Title: Functional defects in six ryanodine receptor isoform-1 (RyR1) mutations associated with malignant hyperthermia and their impact on skeletal excitation-contraction coupling.

Journal: The Journal of biological chemistry 20030711

Title: Multicentre evaluation of in vitro contracture testing with bolus administration of 4-chloro-m-cresol for diagnosis of malignant hyperthermia susceptibility.

Journal: European journal of anaesthesiology 20030701

Title: The British standard series of contact dermatitis allergens: validation in clinical practice and value for clinical governance.

Journal: The British journal of dermatology 20030201

Title: Comparison of viability assays for Cryptosporidium parvum oocysts after disinfection.

Journal: Veterinary parasitology 20030120

Title: Theory of antimicrobial combinations: biocide mixtures - synergy or addition?

Journal: Journal of applied microbiology 20030101

Title: Membrane damage to bacteria caused by single and combined biocides.

Journal: Journal of applied microbiology 20030101

Title: In vitro antileishmanial effects of antibacterial diterpenes from two Ethiopian Premna species: P. schimperi and P. oligotricha.

Journal: BMC pharmacology 20030101

Title: Calcium release from sarcoplasmic reticulum is facilitated in human myotubes derived from carriers of the ryanodine receptor type 1 mutations Ile2182Phe and Gly2375Ala.

Journal: Genetic testing 20030101

Title: H2O2 activates ryanodine receptor but has little effect on recovery of releasable Ca2+ content after fatigue.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20021201

Title: Calcium homeostasis and glucose uptake of murine myotubes exposed to insulin, caffeine and 4-chloro-m-cresol.

Journal: Acta physiologica Scandinavica 20021201

Title: 'Noninvasive' testing for malignant hyperthermia susceptibility.

Journal: Anesthesiology 20021101

Title: Patients with malignant hyperthermia demonstrate an altered calcium control mechanism in B lymphocytes.

Journal: Anesthesiology 20021101

Title: Detection of proton release from cultured human myotubes to identify malignant hyperthermia susceptibility.

Journal: Anesthesiology 20021101

Title: Increased sensitivity to 4-chloro-m-cresol and caffeine in primary myotubes from malignant hyperthermia susceptible individuals carrying the ryanodine receptor 1 Thr2206Met (C6617T) mutation.

Journal: Clinical genetics 20020801

Title: Allergic contact dermatitis of the vulva-an overlooked diagnosis.

Journal: Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 20020701

Title: Physicochemical screening of antimicrobial agents as potential preservatives for submicron emulsions.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20020601

Title: Functional and fluorochrome analysis of an exocytotic mutant yields evidence of store-operated Ca2+ influx in Paramecium.

Journal: The Journal of membrane biology 20020501

Title: Silver ions induce Ca2+ release from the SR in vitro by acting on the Ca2+ release channel and the Ca2+ pump.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20020401

Title: Functional properties of EGFP-tagged skeletal muscle calcium-release channel (ryanodine receptor) expressed in COS-7 cells: sensitivity to caffeine and 4-chloro-m-cresol.

Journal: Cell calcium 20020101

Title: Patch testing with Indian standard series.

Journal: Indian journal of dermatology, venereology and leprology 20020101

Title: Sarcoplasmic reticulum Ca(2+) content affects 4-CmC and caffeine contractures of rat skinned skeletal muscle fibers.

Journal: The Japanese journal of physiology 20011201

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Tags:87-64-9 Molecular Formula|87-64-9 MDL|87-64-9 SMILES|87-64-9 2-Chloro-6-methylphenol |Organic_Building_Blocks