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Home Amines 870070-55-6
870070-55-6,MFCD21642026
Catalog No.:AA004GOE

870070-55-6 | 4-Methoxy-7-morpholino-2-[(4-hydroxy-4-methylpiperidino)carbonylamino]benzothiazole

Pack Size
Purity
Availability
Price(USD)
Quantity
  
25mg
98%
in stock  
$85.00   $59.00
- +
250mg
95%
in stock  
$211.00   $148.00
- +
1g
95%
in stock  
$510.00   $357.00
- +
5g
98%
in stock  
$1,775.00   $1,243.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA004GOE
Chemical Name:
4-Methoxy-7-morpholino-2-[(4-hydroxy-4-methylpiperidino)carbonylamino]benzothiazole
CAS Number:
870070-55-6
Molecular Formula:
C19H26N4O4S
Molecular Weight:
406.4991
MDL Number:
MFCD21642026
SMILES:
COc1ccc(c2c1nc(s2)NC(=O)N1CCC(CC1)(C)O)N1CCOCC1
Properties
Properties
 
Form:
Solid  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
554  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
1.7  

Upstream Synthesis Route

[1]Patent:US2005/261289,2005,A1,.Locationinpatent:Page/Pagecolumn7

Downstream Synthesis Route

[1]Patent:US2005/261289,2005,A1.Locationinpatent:Page/Pagecolumn7

[1]InternationalJournalofMedicinalChemistry,2017,vol.2017

[1]InternationalJournalofMedicinalChemistry,2017,vol.2017

[1]Yuan,Gengyang;Jankins,TannerC.;Patrick,ChristopherG.;Philbrook,Phaethon;Sears,Olivia;Hatfield,Stephen;Sitkovsky,Michail;Vasdev,Neil;Liang,StevenH.;Ondrechen,MaryJo;Pollastri,MichaelP.;Jones,GrahamB.[InternationalJournalofMedicinalChemistry,2017,vol.2017]

Literature

Title: Tozadenant (SYN115) in patients with Parkinson's disease who have motor fluctuations on levodopa: a phase 2b, double-blind, randomised trial.

Journal: The Lancet. Neurology 20140801

Title: Adenosine A2A receptor as a drug discovery target.

Journal: Journal of medicinal chemistry 20140508

Title: Quantification of indirect pathway inhibition by the adenosine A2a antagonist SYN115 in Parkinson disease.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20101201

Title: Olivier Barret, et al. Adenosine 2A Receptor Occupancy by Tozadenant and Preladenant in Rhesus Monkeys. J Nucl Med. 2014 Oct;55(10):1712-8.

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