Home Other Building Blocks 870153-29-0
870153-29-0,MFCD33029312
Catalog No.:AA01V7EB

870153-29-0 | PF-00835231

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Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$80.00   $56.00
- +
5mg
≥98%
in stock  
$278.00   $194.00
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10mg
≥98%
in stock  
$473.00   $331.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01V7EB
Chemical Name:
PF-00835231
CAS Number:
870153-29-0
Molecular Formula:
C24H32N4O6
Molecular Weight:
472.5341
MDL Number:
MFCD33029312
SMILES:
OCC(=O)[C@@H](NC(=O)[C@@H](NC(=O)c1[nH]c2c(c1)c(OC)ccc2)CC(C)C)C[C@@H]1CCNC1=O
Properties

Downstream Synthesis Route

[1]Hoffman,RobertL.;Kania,RobertS.;Brothers,MaryA.;Davies,JayF.;Ferre,RoseA.;Gajiwala,KetanS.;He,Mingying;Hogan,RobertJ.;Kozminski,Kirk;Li,LilianY.;Lockner,JonathanW.;Lou,Jihong;Marra,MichelleT.;Mitchell,LennertJ.;Murray,BrionW.;Nieman,JamesA.;Noell,Stephen;Planken,SimonP.;Rowe,Thomas;Ryan,Kevin;Smith,GeorgeJ.;Solowiej,JamesE.;Steppan,ClaireM.;Taggart,Barbara[JournalofMedicinalChemistry,2020,vol.63,#21,p.12725-12747]

[2]CurrentPatentAssignee:PFIZERINC-WO2021/176369,2021,A1

[3]CurrentPatentAssignee:COCRYSTALPHARMA,INC.-WO2021/206876,2021,A1Locationinpatent:Paragraph001354;001362-001363

[4]CurrentPatentAssignee:SORRENTOTHERAPEUTICSINC-WO2022/256434,2022,A1

[1]Hoffman,RobertL.;Kania,RobertS.;Brothers,MaryA.;Davies,JayF.;Ferre,RoseA.;Gajiwala,KetanS.;He,Mingying;Hogan,RobertJ.;Kozminski,Kirk;Li,LilianY.;Lockner,JonathanW.;Lou,Jihong;Marra,MichelleT.;Mitchell,LennertJ.;Murray,BrionW.;Nieman,JamesA.;Noell,Stephen;Planken,SimonP.;Rowe,Thomas;Ryan,Kevin;Smith,GeorgeJ.;Solowiej,JamesE.;Steppan,ClaireM.;Taggart,Barbara[JournalofMedicinalChemistry,2020,vol.63,#21,p.12725-12747]

[1]Hoffman,RobertL.;Kania,RobertS.;Brothers,MaryA.;Davies,JayF.;Ferre,RoseA.;Gajiwala,KetanS.;He,Mingying;Hogan,RobertJ.;Kozminski,Kirk;Li,LilianY.;Lockner,JonathanW.;Lou,Jihong;Marra,MichelleT.;Mitchell,LennertJ.;Murray,BrionW.;Nieman,JamesA.;Noell,Stephen;Planken,SimonP.;Rowe,Thomas;Ryan,Kevin;Smith,GeorgeJ.;Solowiej,JamesE.;Steppan,ClaireM.;Taggart,Barbara[JournalofMedicinalChemistry,2020,vol.63,#21,p.12725-12747]

[1]Hoffman,RobertL.;Kania,RobertS.;Brothers,MaryA.;Davies,JayF.;Ferre,RoseA.;Gajiwala,KetanS.;He,Mingying;Hogan,RobertJ.;Kozminski,Kirk;Li,LilianY.;Lockner,JonathanW.;Lou,Jihong;Marra,MichelleT.;Mitchell,LennertJ.;Murray,BrionW.;Nieman,JamesA.;Noell,Stephen;Planken,SimonP.;Rowe,Thomas;Ryan,Kevin;Smith,GeorgeJ.;Solowiej,JamesE.;Steppan,ClaireM.;Taggart,Barbara[JournalofMedicinalChemistry,2020,vol.63,#21,p.12725-12747]

[2]CurrentPatentAssignee:SCRIPPSRESEARCH-WO2022/261473,2022,A1

[1]CurrentPatentAssignee:PFIZERINC-WO2021/176369,2021,A1Locationinpatent:Paragraph43

[2]Hoffman,RobertL.;Kania,RobertS.;Brothers,MaryA.;Davies,JayF.;Ferre,RoseA.;Gajiwala,KetanS.;He,Mingying;Hogan,RobertJ.;Kozminski,Kirk;Li,LilianY.;Lockner,JonathanW.;Lou,Jihong;Marra,MichelleT.;Mitchell,LennertJ.;Murray,BrionW.;Nieman,JamesA.;Noell,Stephen;Planken,SimonP.;Rowe,Thomas;Ryan,Kevin;Smith,GeorgeJ.;Solowiej,JamesE.;Steppan,ClaireM.;Taggart,Barbara[JournalofMedicinalChemistry,2020,vol.63,#21,p.12725-12747]

[3]CurrentPatentAssignee:SORRENTOTHERAPEUTICSINC-WO2022/256434,2022,A1Locationinpatent:Paragraph00272-00273

[4]CurrentPatentAssignee:SORRENTOTHERAPEUTICSINC-WO2022/256434,2022,A1Locationinpatent:Paragraph00272-00273

[5]CurrentPatentAssignee:SORRENTOTHERAPEUTICSINC-WO2022/256434,2022,A1Locationinpatent:Paragraph00272-00273

Literature

Title: Robert L Hoffman, et al. Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19. J Med Chem. 2020 Nov 12;63(21):12725-12747.

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