Home Amines 870281-82-6
870281-82-6,MFCD19443647
Catalog No.:AA00GTZ9

870281-82-6 | (S)-2-(1-((9H-Purin-6-yl)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one

Pack Size
Purity
Availability
Price(USD)
Quantity
  
25mg
98%
in stock  
$43.00   $30.00
- +
100mg
98%
in stock  
$107.00   $75.00
- +
1g
98%
in stock  
$145.00   $102.00
- +
5g
98%
in stock  
$411.00   $288.00
- +
10g
98%
in stock  
$710.00   $497.00
- +
25g
98%
in stock  
$1,407.00   $985.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00GTZ9
Chemical Name:
(S)-2-(1-((9H-Purin-6-yl)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
CAS Number:
870281-82-6
Molecular Formula:
C22H18FN7O
Molecular Weight:
415.4230
MDL Number:
MFCD19443647
SMILES:
CC[C@@H](c1nc2cccc(c2c(=O)n1c1ccccc1)F)Nc1ncnc2c1nc[nH]2
Properties
Computed Properties
 
Complexity:
685  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
3.7  

Literature

Title: Lannutti BJ, et al. CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability. Blood, 2011, 117(2), 591-594.

Title: Herman SE, et al. Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals. Blood, 2010, 116(12), 2078-2088.

Title: Low PC, et al. PI3Kδ inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model. Nat Commun. 2014 Mar 14;5:3450.

Title: Cooney J, et al. Synergistic targeting of the regulatory and catalytic subunits of PI3Kδ in mature B cell malignancies. Clin Cancer Res. 2018 Mar 1;24(5):1103-1113.

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SDS
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Tags:870281-82-6 Molecular Formula|870281-82-6 MDL|870281-82-6 SMILES|870281-82-6 (S)-2-(1-((9H-Purin-6-yl)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one