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872365-14-5,MFCD22548206
Catalog No.:AA003AQK

872365-14-5 | Fevipiprant

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
99+%
in stock  
$31.00   $22.00
- +
5mg
99+%
in stock  
$75.00   $53.00
- +
25mg
99+%
in stock  
$198.00   $139.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003AQK
Chemical Name:
Fevipiprant
CAS Number:
872365-14-5
Molecular Formula:
C19H17F3N2O4S
Molecular Weight:
426.4095
MDL Number:
MFCD22548206
SMILES:
OC(=O)Cc1c(C)n(c2c1cccn2)Cc1ccc(cc1C(F)(F)F)S(=O)(=O)C
Properties
Computed Properties
 
Complexity:
709  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
2.8  

Literature

Title: Fevipiprant (QAW039), a Slowly Dissociating CRTh2 Antagonist with the Potential for Improved Clinical Efficacy.

Journal: Molecular pharmacology 20160501

Title: Brightling C, et al. The pharmacology of the prostaglandin D2 receptor 2 (DP2) receptor antagonist, fevipiprant. Pulm Pharmacol Ther. 2021 Jun;68:102030.

Title: Lee HY, et al. Blockade of thymic stromal lymphopoietin and CRTH2 attenuates airway inflammation in a murine model of allergic asthma. Korean J Intern Med. 2020 May;35(3):619-629.

Title: Weintraub NL, et al. Role of prostaglandin D2 receptors in the pathogenesis of abdominal aortic aneurysm formation. Clin Sci (Lond). 2022 Mar 18;136(5):309-321.

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