Name: Name:Pu-h 71
Brand: AABLOCKS
SKU: AA00GXXK
Rating: 90 (10 reviews)

Catalog No.: AA00GXXK

873436-91-0 | Pu-h 71

Pack Size： 1mg

Purity： 98%

in stock

$30.00 $21.00

Pack Size： 5mg

Purity： 98%

in stock

$87.00 $61.00

Pack Size： 50mg

Purity： 98%

in stock

$373.00 $261.00

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Technical Information

Catalog Number: AA00GXXK

Chemical Name: Pu-h 71

CAS Number: 873436-91-0

Molecular Formula: C18H21IN6O2S

Molecular Weight: 512.3678

MDL Number: MFCD18251588

SMILES: CC(NCCCn1c(Sc2cc3OCOc3cc2I)nc2c1ncnc2N)C

NSC Number: 752199

Properties

Complexity: 521

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 28

Hydrogen Bond Acceptor Count: 8

Hydrogen Bond Donor Count: 2

Isotope Atom Count: 0

Rotatable Bond Count: 7

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 3.2

Downstream Synthesis Route

873437-14-0

873436-91-0

[1]He,Huazhong;Zatorska,Danuta;Kim,Joungnam;Aguirre,Julia;Llauger,Laura;She,Yuhong;Wu,Nian;Immormino,RobertM.;Gewirth,DanielT.;Chiosis,Gabriela[JournalofMedicinalChemistry,2006,vol.49,#1,p.381-390]

873436-91-0

CASUnavailable

1289543-79-8

[1]CurrentPatentAssignee:MEMORIALSLOAN-KETTERINGCANCERCENTER-WO2011/44394,2011,A1Locationinpatent:Page/Pagecolumn81

[2]Taldone,Tony;Zatorska,Danuta;Patel,HardikJ.;Sun,Weilin;Patel,MaulikR.;Chiosis,Gabriela[Heterocycles,2013,vol.87,#1,p.91-113]

8-(6-iodo-benzo1,3dioxol-5-ylsulfanyl)-9-(3-isopropylamino-propyl)adenine

145214-05-7

1289544-82-6

[1]Patent:WO2011/44394,2011,A1.Locationinpatent:Page/Pagecolumn139

[2]Heterocycles,2013,vol.87,p.91-113

8-(6-iodo-benzo1,3dioxol-5-ylsulfanyl)-9-(3-isopropylamino-propyl)adenine

121359-48-6

1289544-83-7

[1]Patent:WO2011/44394,2011,A1.Locationinpatent:Page/Pagecolumn139

[2]Heterocycles,2013,vol.87,p.91-113

873436-91-0

55552-70-0

1289543-83-4

[1]CurrentPatentAssignee:MEMORIALSLOAN-KETTERINGCANCERCENTER-WO2011/44394,2011,A1Locationinpatent:Page/Pagecolumn83

[2]Taldone,Tony;Zatorska,Danuta;Patel,HardikJ.;Sun,Weilin;Patel,MaulikR.;Chiosis,Gabriela[Heterocycles,2013,vol.87,#1,p.91-113]

Literature fold

Title: Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94.

Journal: Journal of medicinal chemistry20150514

Title: Discovery and validation of small-molecule heat-shock protein 90 inhibitors through multimodality molecular imaging in living subjects.

Journal: Proceedings of the National Academy of Sciences of the United States of America20120911

Title: Systematic identification of the HSP90 candidate regulated proteome.

Journal: Molecular & cellular proteomics : MCP20120601

Title: Measuring the pharmacodynamic effects of a novel Hsp90 inhibitor on HER2/neu expression in mice using Zr-DFO-trastuzumab.

Journal: PloS one20100101

Title: The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1.

Journal: Journal of hematology & oncology20100101

Title: Targeting heat shock protein 90 with non-quinone inhibitors: a novel chemotherapeutic approach in human hepatocellular carcinoma.

Journal: Hepatology (Baltimore, Md.)20090701

Title: Discovery and development of heat shock protein 90 inhibitors.

Journal: Bioorganic & medicinal chemistry20090315

Title: Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling.

Journal: Bioorganic & medicinal chemistry20080715

Title: The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20080326

Title: Molecular imaging of the efficacy of heat shock protein 90 inhibitors in living subjects.

Journal: Cancer research20080101

Title: Synthesis of a red-shifted fluorescence polarization probe for Hsp90.

Journal: Bioorganic & medicinal chemistry letters20060901

Title: Structural and quantum chemical studies of 8-aryl-sulfanyl adenine class Hsp90 inhibitors.

Journal: Journal of medicinal chemistry20060810

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