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875337-44-3,MFCD17779287
Catalog No.:AA003AI4

875337-44-3 | Mgcd-265

Pack Size
Purity
Availability
Price(USD)
Quantity
  
2mg
98+%
in stock  
$51.00   $36.00
- +
5mg
98%
in stock  
$116.00   $82.00
- +
25mg
98%
in stock  
$291.00   $204.00
- +
50mg
95%
in stock  
$446.00   $312.00
- +
100mg
95%
in stock  
$644.00   $451.00
- +
250mg
95%
in stock  
$1,046.00   $732.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003AI4
Chemical Name:
Mgcd-265
CAS Number:
875337-44-3
Molecular Formula:
C26H20FN5O2S2
Molecular Weight:
517.5977
MDL Number:
MFCD17779287
SMILES:
S=C(NC(=O)Cc1ccccc1)Nc1ccc(c(c1)F)Oc1ccnc2c1sc(c2)c1ncn(c1)C
Properties
Computed Properties
 
Complexity:
773  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
4.9  

Downstream Synthesis Route

[1]Claridge,Stephen;Raeppel,Franck;Granger,Marie-Claude;Bernstein,Naomy;Saavedra,Oscar;Zhan,Lijie;Llewellyn,David;Wahhab,Amal;Deziel,Robert;Rahil,Jubrail;Beaulieu,Normand;Nguyen,Hannah;Dupont,Isabelle;Barsalou,Annie;Beaulieu,Carole;Chute,Ian;Gravel,Serge;Robert,Marie-France;Lefebvre,Sylvain;Dubay,Marja;Pascal,Roussen;Gillespie,Jeff;Jin,Zhiyun;Wang,James;Besterman,JeffreyM.;MacLeod,A.Robert;Vaisburg,Arkadii[BioorganicandMedicinalChemistryLetters,2008,vol.18,#9,p.2793-2798]

Literature

Title: N-(4-(6,7-Disubstituted-quinolin-4-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: a novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20091201

Title: N-(3-fluoro-4-(2-arylthieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: a novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20090301

Title: Discovery of a novel and potent series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases.

Journal: Bioorganic & medicinal chemistry letters 20080501

Title: Claridge S, et al. Discovery of a novel and potent series of thieno,2-bpyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases. Bioorg Med Chem Lett. 2008 May 1;18(9):2793-8.

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SDS
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Tags:875337-44-3 Molecular Formula|875337-44-3 MDL|875337-44-3 SMILES|875337-44-3 Mgcd-265