Home Other Building Blocks 876708-03-1
876708-03-1,MFCD22665689
Catalog No.:AA00GU3D

876708-03-1 | RO 9187

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥99%
in stock  
$488.00   $342.00
- +
10mg
≥99%
in stock  
$620.00   $434.00
- +
50mg
≥99%
in stock  
$1,593.00   $1,115.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00GU3D
Chemical Name:
RO 9187
CAS Number:
876708-03-1
Molecular Formula:
C9H12N6O5
Molecular Weight:
284.2288
MDL Number:
MFCD22665689
SMILES:
[N-]=[N+]=NC1(CO)OC(C(C1O)O)n1ccc(nc1=O)N
Properties
Computed Properties
 
Complexity:
529  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
3  
Undefined Bond Stereocenter Count:
1  
XLogP3:
-1.8  

Literature

Title: Defibrotide interferes with several steps of the coagulation-inflammation cycle and exhibits therapeutic potential to treat severe malaria.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20120301

Title: The design, synthesis, and antiviral activity of monofluoro and difluoro analogues of 4'-azidocytidine against hepatitis C virus replication: the discovery of 4'-azido-2'-deoxy-2'-fluorocytidine and 4'-azido-2'-dideoxy-2',2'-difluorocytidine.

Journal: Journal of medicinal chemistry 20090514

Title: The design, synthesis, and antiviral activity of 4'-azidocytidine analogues against hepatitis C virus replication: the discovery of 4'-azidoarabinocytidine.

Journal: Journal of medicinal chemistry 20090108

Title: 2'-deoxy-4'-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2'-alpha-hydroxyl groups.

Journal: The Journal of biological chemistry 20080125

Title: Klumpp K, et al. 2'-deoxy-4'-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2'-alpha-hydroxyl groups. J Biol Chem. 2008 Jan 25;283(4):2167-75.

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