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87687-03-4,MFCD00037664
Catalog No.:AA00GV6G

87687-03-4 | RESORUFIN PENTYL ETHER

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1mg
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00GV6G
Chemical Name:
RESORUFIN PENTYL ETHER
CAS Number:
87687-03-4
Molecular Formula:
C17H19NO2
Molecular Weight:
269.3383
MDL Number:
MFCD00037664
SMILES:
CCCCCOc1ccc2c(c1)Oc1c(N2)cccc1
Properties
Computed Properties
 
Complexity:
492  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
4  
Rotatable Bond Count:
5  
XLogP3:
3.2  

Literature

Title: Different profiles of hepatic alkoxyresorufin O-dealkylase activities in small rodents.

Journal: Journal of applied toxicology : JAT 20121201

Title: Induction of cytochrome P450 family 1 mRNAs and activities in a cell line from the frog Xenopus laevis.

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20120615

Title: Verapamil does not modify catalytic activity of CYP450 in rainbow trout after long-term exposure.

Journal: Ecotoxicology and environmental safety 20120501

Title: Development of on-line high performance liquid chromatography (HPLC)-biochemical detection methods as tools in the identification of bioactives.

Journal: International journal of molecular sciences 20120101

Title: Immunochemical detection of cytochrome P450 enzymes in liver microsomes of 27 cynomolgus monkeys.

Journal: The Journal of pharmacology and experimental therapeutics 20111101

Title: Characterization of enzyme activities of Cytochrome P450 enzymes, Flavin-dependent monooxygenases, N-acetyltransferases and UDP-glucuronyltransferases in human reconstructed epidermis and full-thickness skin models.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20110901

Title: Liquid|liquid|electrode triple-phase boundary photovoltammetry of pentoxyresorufin in 4-(3-phenylpropyl)pyridine.

Journal: Langmuir : the ACS journal of surfaces and colloids 20110517

Title: In vivo indirect measurement of cytochrome P450-associated activities in freshwater gastropod molluscs.

Journal: Environmental toxicology 20101201

Title: Phenethyl isocyanate is not the metabolite of phenethyl isothiocyanate responsible for mechanism-based inhibition of cytochrome P450.

Journal: Archives of toxicology 20101001

Title: Human blood concentrations of cotinine, a biomonitoring marker for tobacco smoke, extrapolated from nicotine metabolism in rats and humans and physiologically based pharmacokinetic modeling.

Journal: International journal of environmental research and public health 20100901

Title: Biotransformation of PCBs in Arctic seabirds: characterization of phase I and II pathways at transcriptional, translational and activity levels.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20100601

Title: Assessment of cytochrome P450 fluorometric substrates with rainbow trout and killifish exposed to dexamethasone, pregnenolone-16alpha-carbonitrile, rifampicin, and beta-naphthoflavone.

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20100510

Title: 7-Benzyloxyresorufin-O-dealkylase activity as a marker for measuring cytochrome P450 CYP3A induction in mouse liver.

Journal: Analytical biochemistry 20100301

Title: Comparison of cytochrome P450 3A enzymes in cynomolgus monkeys and humans.

Journal: Drug metabolism and pharmacokinetics 20100101

Title: The effects of selected flavonoids on cytochromes P450 in rat liver and small intestine.

Journal: Interdisciplinary toxicology 20090901

Title: Inhibitive effect of diphenytriazol on rat cytochrome P450 enzyme in vitro.

Journal: Die Pharmazie 20090701

Title: Developmental exposure to polychlorinated biphenyls interferes with experience-dependent dendritic plasticity and ryanodine receptor expression in weanling rats.

Journal: Environmental health perspectives 20090301

Title: Modulation of rat pulmonary carcinogen-metabolising enzyme systems by the isothiocyanates erucin and sulforaphane.

Journal: Chemico-biological interactions 20090127

Title: Development of an optimized procedure for the preparation of rat intestinal microsomes: comparison of hepatic and intestinal microsomal cytochrome P450 enzyme activities in two rat strains.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20090101

Title: Tissue differences in the modulation of rat cytochromes P450 and phase II conjugation systems by dietary doses of phenethyl isothiocyanate.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20081201

Title: Precision-cut liver slices from rats of different ages: basal cytochrome P450-dependent monooxygenase activities and inducibility.

Journal: Analytical and bioanalytical chemistry 20081101

Title: Up-regulation of the CYP1 family in rat and human liver by the aliphatic isothiocyanates erucin and sulforaphane.

Journal: Toxicology 20081030

Title: Modulation of steroidogenesis and xenobiotic biotransformation responses in zebrafish (Danio rerio) exposed to water-soluble fraction of crude oil.

Journal: Environmental research 20080701

Title: Evidence that the anticarcinogenic effect of caffeic acid phenethyl ester in the resistant hepatocyte model involves modifications of cytochrome P450.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20080701

Title: The polybrominated diphenyl ether mixture DE-71 is mildly estrogenic.

Journal: Environmental health perspectives 20080501

Title: Developmental exposure to polychlorinated biphenyls influences stroke outcome in adult rats.

Journal: Environmental health perspectives 20080401

Title: Characterization of Phase I biotransformation enzymes in coho salmon (Oncorhynchus kisutch).

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20080101

Title: Mouse mammary tumor virus promoter-containing retroviral promoter conversion vectors for gene-directed enzyme prodrug therapy are functional in vitro and in vivo.

Journal: Journal of biomedicine & biotechnology 20080101

Title: Purification of CYP2B-like protein from feral leaping mullet (Liza saliens) liver microsomes and its biocatalytic, molecular, and immunological characterization.

Journal: Journal of biochemical and molecular toxicology 20080101

Title: [The optical biosensor study of the redox partners interactions within the cytochrome P450 2B4-containing monooxygenase system in hydroxylation conditions].

Journal: Biomeditsinskaia khimiia 20080101

Title: Viral infection and PBDE exposure interact on CYP gene expression and enzyme activities in the mouse liver.

Journal: Toxicology 20071205

Title: Effect of perinatal low protein diets on the ontogeny of select hepatic cytochrome p450 enzymes and cytochrome p450 reductase in the rat.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20070701

Title: Expression and characterization of cytochrome P450 2X1 in channel catfish (Ictalurus punctatus).

Journal: Biochimica et biophysica acta 20070701

Title: Development of three parallel cytochrome P450 enzyme affinity detection systems coupled on-line to gradient high-performance liquid chromatography.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20070401

Title: Modulation of xenobiotic biotransformation system and hormonal responses in Atlantic salmon (Salmo salar) after exposure to tributyltin (TBT).

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20070401

Title: Chromatin remodeling agent trichostatin A: a key-factor in the hepatic differentiation of human mesenchymal stem cells derived of adult bone marrow.

Journal: BMC developmental biology 20070101

Title: Interactive effects of methyl tertiary-butyl ether (MTBE) and tertiary-amyl methyl ether (TAME), ethanol and some drugs: Triglyceridemia, liver toxicity and induction of CYP (2E1, 2B1) and phase II enzymes in female Wistar rats.

Journal: Environmental toxicology and pharmacology 20070101

Title: Heteromeric complex formation between CYP2E1 and CYP1A2: evidence for the involvement of electrostatic interactions.

Journal: Biochemistry 20061226

Title: Cooperation of the inducible nitric oxide synthase and cytochrome P450 1A1 in mediating lung inflammation and mutagenicity induced by diesel exhaust particles.

Journal: Environmental health perspectives 20060801

Title: Stability of cytochromes P450 and phase II conjugation systems in precision-cut rat lung slices cultured up to 72 h.

Journal: Toxicology 20060705

Title: Effect of sulfur dioxide inhalation on CYP2B1/2 and CYP2E1 in rat liver and lung.

Journal: Inhalation toxicology 20060701

Title: Enzymatic analysis of cDNA-expressed human CYP1A1, CYP1A2, and CYP1B1 with 7-ethoxyresorufin as substrate.

Journal: Methods in molecular biology (Clifton, N.J.) 20060101

Title: Modulation of hepatic cytochromes P450 and phase II enzymes by dietary doses of sulforaphane in rats: Implications for its chemopreventive activity.

Journal: International journal of cancer 20051110

Title: Induction of rat hepatic cytochrome P-450 by ketamine and its toxicological implications.

Journal: Journal of toxicology and environmental health. Part A 20050901

Title: Effects of light and dark beer on hepatic cytochrome P-450 expression in male rats receiving alcoholic beverages as part of total enteral nutrition.

Journal: Alcoholism, clinical and experimental research 20050501

Title: Effects of ionic strength on the functional interactions between CYP2B4 and CYP1A2.

Journal: Biochemistry 20050222

Title: Lack of strain-related differences in drug metabolism and efflux transporter characteristics between CD-1 and athymic nude mice.

Journal: Cancer chemotherapy and pharmacology 20050201

Title: Black tea intake modulates the excretion of urinary mutagens in rats exposed to 6-aminochrysene: induction of cytochromes P450 by 6-aminochrysene in the rat.

Journal: Mutagenesis 20050101

Title: Mechanism to study 1:1 stoichiometry of NADPH and alkoxyphenoxazones metabolism spectrophotometrically in subcellular biological preparations.

Journal: Biochimica et biophysica acta 20041118

Title: In vitro biotransformation of 3,4-dihydro-6-hydroxy-2,2-dimethyl-7-methoxy-1(2H)-benzopyran (CR-6), a potent lipid peroxidation inhibitor and nitric oxide scavenger, in rat liver microsomes.

Journal: Chemical research in toxicology 20040701

Title: Quantitative structure-activity relationships within a homologous series of 7-alkoxyresorufins exhibiting activity towards CYP1A and CYP2B enzymes: molecular modelling studies on key members of the resorufin series with CYP2C5-derived models of human CYP1A1, CYP1A2, CYP2B6 and CYP3A4.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20040601

Title: Effects of propranolol on xenobiotic enzyme activities in rat type II pneumocytes and alveolar macrophages in vivo.

Journal: Methods and findings in experimental and clinical pharmacology 20031201

Title: Hepatic and intestinal cytochrome P450 and conjugase activities in rats treated with black tea theafulvins and theaflavins.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20030801

Title: Characterization of substrate binding to cytochrome P450 1A1 using molecular modeling and kinetic analyses: case of residue 382.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20030401

Title: Catalytic activities of cytochrome P450 enzymes and UDP-glucuronosyltransferases involved in drug metabolism in rat everted sacs and intestinal microsomes.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20030101

Title: Alteration of pulmonary cytochrome p-450 system: effects of asphalt fume condensate exposure.

Journal: Journal of toxicology and environmental health. Part A 20020913

Title: Biochemical factors underlying the age-related sensitivity of turkeys to aflatoxin B(1).

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20020601

Title: A spectrophotometric method to monitor the catalytic activity of microsomal cytochrome P-450 IIB1/2: comparison with fluorometric assay.

Journal: Indian journal of biochemistry & biophysics 20020601

Title: Evidence for the presence of active cytochrome P450 systems in Schistosoma mansoni and Schistosoma haematobium adult worms.

Journal: FEBS letters 20020522

Title: A novel approach to study the activity and stoichiometry simultaneously for microsomal pentoxyresorufin-O-dealkylase reaction.

Journal: FEBS letters 20020213

Title: Detection of the embryotoxic potential of cyclophosphamide by using a combined system of metabolic competent cells and embryonic stem cells.

Journal: Alternatives to laboratory animals : ATLA 20020101

Title: Effects of trivalent chromium on hepatic CYP-linked monooxygenases in laying hens.

Journal: Journal of applied toxicology : JAT 20020101

Title: Xenobiotic-metabolizing enzyme activities in primary cultures of rat type II pneumocytes and alveolar macrophages.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20011001

Title: Role of induction of specific hepatic cytochrome P450 isoforms in epoxidation of 4-vinylcyclohexene.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20010901

Title: Inhibition of rat liver microsomal CYP1A2 and CYP2B1 activity by N-(2-heptyl)-N-methyl-propargylamine and by N-(2-heptyl)-propargylamine.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20010801

Title: Effect of alpha-methyldopa on pentoxyresorufin O-dealkylation in liver microsomes from rats treated with phenobarbital.

Journal: Archives of biochemistry and biophysics 20010801

Title: Induction of rat brain cytochrome P450s (P450s) by deltamethrin: regional specificity and correlation with neurobehavioral toxicity.

Journal: Neurotoxicity research 20010801

Title: Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20010601

Title: Co-expression of human cytochrome P4501A1 (CYP1A1) variants and human NADPH-cytochrome P450 reductase in the baculovirus/insect cell system.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20010601

Title: Propofol-induced cytochrome P450 inhibition: an in vitro and in vivo study in rats.

Journal: Life sciences 20010518

Title: The role of actin filaments and microtubules in hepatocyte spheroid self-assembly.

Journal: Cell motility and the cytoskeleton 20010301

Title: Probing enhanced cytochrome P450 2B1/2 activity in rat hepatocyte spheroids through confocal laser scanning microscopy.

Journal: Cell transplantation 20010101

Title: Induction of hepatic cytochrome P-450 by phenobarbital in semi-aquatic frog (Rana pipiens).

Journal: Biochemical and biophysical research communications 19980327

Title: Cytochrome P450-dependent drug oxidation activities in liver microsomes of various animal species including rats, guinea pigs, dogs, monkeys, and humans.

Journal: Archives of toxicology 19970101

Title: Stable expression and coexpression of human cytochrome P450 oxidoreductase and cytochrome P450 1A2 in V79 Chinese hamster cells: sensitivity to quinones and biotransformation of 7-alkoxyresorufins and triazines.

Journal: Drug metabolism and disposition: the biological fate of chemicals 19961201

Title: Deanna M. Schmitt, et al. Antibacterial activity of resazurin-based compounds against Neisseria gonorrhoeae in vitro and in vivo. Int J Antimicrob Agents. 2016 Oct; 48(4): 367–372.

Title: M D Burke, et al. Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450. Biochem Pharmacol. 1985 Sep 15;34(18):3337-45.

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