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Journal: Toxicology letters 20180701
Title: 5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-((4-methylpiperazin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)phenyl)pyrimidine-2,4-diamine (WY-135), a novel ALK inhibitor, induces cell cycle arrest and apoptosis through inhibiting ALK and its downstream pathways in Karpas299 and H2228 cells.
Journal: Chemico-biological interactions 20180325
Title: Editor's Highlight: PlacentalDisposition and Effects of Crizotinib: An Ex Vivo Study in the Isolated Dual-Side Perfused Human Cotyledon.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20170601
Title: Discovery of Brigatinib (AP26113), a Phosphine Oxide-Containing, Potent, Orally Active Inhibitor of Anaplastic Lymphoma Kinase.
Journal: Journal of medicinal chemistry 20160526
Title: Resensitization to Crizotinib by the Lorlatinib ALK Resistance Mutation L1198F.
Journal: The New England journal of medicine 20160107
Title: Activity of second-generation ALK inhibitors against crizotinib-resistant mutants in an NPM-ALK model compared to EML4-ALK.
Journal: Cancer medicine 20150701
Title: PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20150317
Title: Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects.
Journal: International journal of molecular sciences 20150101
Title: Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib.
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Title: Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants.
Journal: Journal of medicinal chemistry 20141009
Title: Selective ALK inhibitor alectinib with potent antitumor activity in models of crizotinib resistance.
Journal: Cancer letters 20140901
Title: ALK inhibitors in non-small cell lung cancer: crizotinib and beyond.
Journal: Clinical advances in hematology & oncology : H&O 20140701
Title: Discovery of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain exposure and broad-spectrum potency against ALK-resistant mutations.
Journal: Journal of medicinal chemistry 20140612
Title: The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer.
Journal: Cancer discovery 20140601
Title: Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy.
Journal: Nature 20140410
Title: Design of potent and selective inhibitors to overcome clinical anaplastic lymphoma kinase mutations resistant to crizotinib.
Journal: Journal of medicinal chemistry 20140227
Title: Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes.
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Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.
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Title: Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials.
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Title: Crizotinib for the treatment of non-small-cell lung cancer.
Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20130601
Title: Targeted agents in the third-/fourth-line treatment of patients with advanced (stage III/IV) non-small cell lung cancer (NSCLC).
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Title: Development and validation of a high-throughput intrinsic ATPase activity assay for the discovery of MEKK2 inhibitors.
Journal: Journal of biomolecular screening 20130401
Title: Cell culture and Drosophila model systems define three classes of anaplastic lymphoma kinase mutations in neuroblastoma.
Journal: Disease models & mechanisms 20130301
Title: Prediction of crizotinib-midazolam interaction using the Simcyp population-based simulator: comparison of CYP3A time-dependent inhibition between human liver microsomes versus hepatocytes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20130201
Title: Overcoming erlotinib resistance with tailored treatment regimen in patient-derived xenografts from naïve Asian NSCLC patients.
Journal: International journal of cancer 20130115
Title: Enhancement of the antiproliferative activity of gemcitabine by modulation of c-Met pathway in pancreatic cancer.
Journal: Current pharmaceutical design 20130101
Title: Anaplastic Lymphoma Kinase (ALK) regulates initiation of transcription of MYCN in neuroblastoma cells.
Journal: Oncogene 20121213
Title: Isolated central nervous system progression on Crizotinib: an Achilles heel of non-small cell lung cancer with EML4-ALK translocation?
Journal: Cancer biology & therapy 20121201
Title: Adenocarcinoma of the lung with miliary brain and pulmonary metastases with echinoderm microtubule-associated protein like 4-anaplastic lymphoma kinase translocation treated with crizotinib: a case report.
Journal: Lung cancer (Amsterdam, Netherlands) 20121201
Title: Antibody targeting of anaplastic lymphoma kinase induces cytotoxicity of human neuroblastoma.
Journal: Oncogene 20121115
Title: Activation of HER family signaling as a mechanism of acquired resistance to ALK inhibitors in EML4-ALK-positive non-small cell lung cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20121115
Title: Hypogonadism related to crizotinib therapy: implications for patient care.
Journal: Cancer 20121101
Title: Rapid-onset hypogonadism secondary to crizotinib use in men with metastatic nonsmall cell lung cancer.
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Title: Histologic and cytomorphologic features of ALK-rearranged lung adenocarcinomas.
Journal: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 20121101
Title: ALK alterations in adult renal cell carcinoma: frequency, clinicopathologic features and outcome in a large series of consecutively treated patients.
Journal: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 20121101
Title: Targeted therapy for lung cancer.
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Title: The R1275Q neuroblastoma mutant and certain ATP-competitive inhibitors stabilize alternative activation loop conformations of anaplastic lymphoma kinase.
Journal: The Journal of biological chemistry 20121026
Title: Crizotinib in ALK-positive lung cancer.
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Title: Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study.
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Title: Treatment of ALK-positive non-small cell lung cancer.
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Title: Discovery of a novel class of exquisitely selective mesenchymal-epithelial transition factor (c-MET) protein kinase inhibitors and identification of the clinical candidate 2-(4-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol (PF-04217903) for the treatment of cancer.
Journal: Journal of medicinal chemistry 20120927
Title: Correlations between the percentage of tumor cells showing an anaplastic lymphoma kinase (ALK) gene rearrangement, ALK signal copy number, and response to crizotinib therapy in ALK fluorescence in situ hybridization-positive nonsmall cell lung cancer.
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Title: Liquid chromatography-tandem mass spectrometric assay for the ALK inhibitor crizotinib in mouse plasma.
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Title: EML4-ALK testing in non-small cell carcinomas of the lung: a review with recommendations.
Journal: Virchows Archiv : an international journal of pathology 20120901
Title: Discovery of novel 2-aminopyridine-3-carboxamides as c-Met kinase inhibitors.
Journal: Bioorganic & medicinal chemistry 20120901
Title: Differential protein stability and ALK inhibitor sensitivity of EML4-ALK fusion variants.
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Title: Variants on a theme: a biomarker of crizotinib response in ALK-positive non-small cell lung cancer?
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Title: Identifying and targeting ROS1 gene fusions in non-small cell lung cancer.
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Title: Targeting ALK: a promising strategy for the treatment of non-small cell lung cancer, non-Hodgkin's lymphoma, and neuroblastoma.
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Title: [Cavitating nodules in a 40-year-old non-smoking woman: a very particular tumour].
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Title: Histology- and non-histology-driven therapy for treatment of soft tissue sarcomas.
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Title: Echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase-targeted therapy for advanced non-small cell lung cancer: molecular and clinical aspects.
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Title: ALK-mutated non-small-cell lung cancer: a new strategy for cancer treatment.
Journal: Lung 20120801
Title: Disease flare after treatment discontinuation in a patient with EML4-ALK lung cancer and acquired resistance to crizotinib.
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20120801
Title: Crizotinib for ALK-rearranged non-small cell lung cancer: a new targeted therapy for a new target.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20120715
Title: The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastoma.
Journal: Cancer cell 20120710
Title: Crizotinib (PF-02341066) reverses multidrug resistance in cancer cells by inhibiting the function of P-glycoprotein.
Journal: British journal of pharmacology 20120701
Title: HGF/c-Met pathway is one of the mediators of sunitinib-induced tumor cell type-dependent metastasis.
Journal: Cancer letters 20120701
Title: Paracrine receptor activation by microenvironment triggers bypass survival signals and ALK inhibitor resistance in EML4-ALK lung cancer cells.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20120701
Title: Inhibitors of the anaplastic lymphoma kinase.
Journal: Expert opinion on investigational drugs 20120701
Title: Preclinical rationale for use of the clinically available multitargeted tyrosine kinase inhibitor crizotinib in ROS1-translocated lung cancer.
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20120701
Title: Anaplastic lymphoma kinase-directed therapy in inflammatory myofibroblastic tumors.
Journal: Current opinion in oncology 20120701
Title: Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia.
Journal: Nature medicine 20120701
Title: Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF-02341066) in gastric cancer positive for MET amplification.
Journal: Molecular cancer therapeutics 20120701
Title: Personalized medicine and pharmacogenetic biomarkers: progress in molecular oncology testing.
Journal: Expert review of molecular diagnostics 20120701
Title: Identification of basophils as a major source of hepatocyte growth factor in chronic myeloid leukemia: a novel mechanism of BCR-ABL1-independent disease progression.
Journal: Neoplasia (New York, N.Y.) 20120701
Title: A molecular dynamics investigation on the crizotinib resistance mechanism of C1156Y mutation in ALK.
Journal: Biochemical and biophysical research communications 20120629
Title: Targeted therapy for NSCLC: ALK inhibition.
Journal: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 20120601
Title: Histologic subtypes, immunohistochemistry, FISH or molecular screening for the accurate diagnosis of ALK-rearrangement in lung cancer: a comprehensive study of Caucasian non-smokers.
Journal: Lung cancer (Amsterdam, Netherlands) 20120601
Title: Detection of anaplastic lymphoma kinase (ALK) gene rearrangement in non-small cell lung cancer and related issues in ALK inhibitor therapy: a literature review.
Journal: Molecular diagnosis & therapy 20120601
Title: Remarkable tumor response to crizotinib in a 14-year-old girl with ALK-positive non-small-cell lung cancer.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120601
Title: Development of treatment strategies for advanced neuroblastoma.
Journal: International journal of clinical oncology 20120601
Title: Crizotinib in the treatment of non-small-cell lung cancer.
Journal: Expert opinion on pharmacotherapy 20120601
Title: ALKoma: a cancer subtype with a shared target.
Journal: Cancer discovery 20120601
Title: Novel molecular trends in the management of advanced non-small-cell lung cancer.
Journal: Expert review of anticancer therapy 20120601
Title: Biomarkers that currently affect clinical practice: EGFR, ALK, MET, KRAS.
Journal: Current oncology (Toronto, Ont.) 20120601
Title: Treatment paradigms for patients with metastatic non-small-cell lung cancer: first-, second-, and third-line.
Journal: Current oncology (Toronto, Ont.) 20120601
Title: Supportive care treatments for toxicities of anti-egfr and other targeted agents.
Journal: Current oncology (Toronto, Ont.) 20120601
Title: Discovery of an orally efficacious inhibitor of anaplastic lymphoma kinase.
Journal: Journal of medicinal chemistry 20120524
Title: Targeting ALK in neuroblastoma--preclinical and clinical advancements.
Journal: Nature reviews. Clinical oncology 20120515
Title: Promising therapeutic targets in neuroblastoma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20120515
Title: ALK inhibitor crizotinib combined with intrathecal methotrexate treatment for non-small cell lung cancer with leptomeningeal carcinomatosis.
Journal: Lung cancer (Amsterdam, Netherlands) 20120501
Title: ALK translocation and crizotinib in non-small cell lung cancer: an evolving paradigm in oncology drug development.
Journal: European journal of cancer (Oxford, England : 1990) 20120501
Title: Treating ALK-positive lung cancer--early successes and future challenges.
Journal: Nature reviews. Clinical oncology 20120501
Title: Application of mid-infrared spectroscopy to the development and transfer of a manufacturing process for an active pharmaceutical ingredient.
Journal: Applied spectroscopy 20120501
Title: [Which platform to support a personalized lung cancer treatment?].
Journal: Bulletin du cancer 20120501
Title: Novel approaches of chemoradiotherapy in unresectable stage IIIA and stage IIIB non-small cell lung cancer.
Journal: The oncologist 20120501
Title: Advances in treatment of lung cancer with targeted therapy.
Journal: Archives of pathology & laboratory medicine 20120501
Title: Discovery pharmacokinetic studies in mice using serial microsampling, dried blood spots and microbore LC-MS/MS.
Journal: Bioanalysis 20120501
Title: Personalized targeted therapy in advanced non-small cell lung cancer.
Journal: Cleveland Clinic journal of medicine 20120501
Title: Treating ALK-positive lung cancer in the weeks after the FDA approval of crizotinib.
Journal: The American journal of managed care 20120501
Title: Treating Anaplastic Lymphoma Kinase-Positive Lung Cancer in the Weeks After the US Food and Drug Administration Approval of Crizotinib.
Journal: Journal of oncology practice 20120501
Title: Aberrant expression of the transcriptional factor Twist1 promotes invasiveness in ALK-positive anaplastic large cell lymphoma.
Journal: Cellular signalling 20120401
Title: The biology and clinical features of non-small cell lung cancers with EML4-ALK translocation.
Journal: Current oncology reports 20120401
Title: The emerging role of ALK inhibitors in the treatment of advanced non-small cell lung cancer.
Journal: Expert opinion on therapeutic targets 20120401
Title: Astellas' drug discovery strategy: focus on oncology.
Journal: Japanese journal of clinical oncology 20120401
Title: RNA-Seq mapping and detection of gene fusions with a suffix array algorithm.
Journal: PLoS computational biology 20120401
Title: ROS1 as a 'druggable' receptor tyrosine kinase: lessons learned from inhibiting the ALK pathway.
Journal: Expert review of anticancer therapy 20120401
Title: Crizotinib for the treatment of patients with advanced non-small cell lung cancer.
Journal: Drugs of today (Barcelona, Spain : 1998) 20120401
Title: Recent advances in non-small cell lung cancer biology and clinical management.
Journal: Discovery medicine 20120401
Title: Redefining clinical trials: the age of personalized medicine.
Journal: Cell 20120316
Title: The cost-effectiveness of screening lung cancer patients for targeted drug sensitivity markers.
Journal: British journal of cancer 20120313
Title: ROS1 rearrangements define a unique molecular class of lung cancers.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120310
Title: Pharmacokinetic/pharmacodynamic modeling of crizotinib for anaplastic lymphoma kinase inhibition and antitumor efficacy in human tumor xenograft mouse models.
Journal: The Journal of pharmacology and experimental therapeutics 20120301
Title: Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20120301
Title: LRIG1 modulates cancer cell sensitivity to Smac mimetics by regulating TNFα expression and receptor tyrosine kinase signaling.
Journal: Cancer research 20120301
Title: Acquired resistance to the ALK inhibitor crizotinib in the absence of an ALK mutation.
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20120301
Title: Present status and problems on molecular targeted therapy of cancer.
Journal: Cancer research and treatment : official journal of Korean Cancer Association 20120301
Title: Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers.
Journal: Science translational medicine 20120208
Title: Escaping ALK inhibition: mechanisms of and strategies to overcome resistance.
Journal: Science translational medicine 20120208
Title: Crizotinib (xalkori) for non-small cell lung cancer.
Journal: The Medical letter on drugs and therapeutics 20120206
Title: Tyrosine kinase gene fusions in cancer: translating mechanisms into targeted therapies.
Journal: Journal of cellular and molecular medicine 20120201
Title: Dual IHC and FISH testing for ALK gene rearrangement in lung adenocarcinomas in a routine practice: a French study.
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20120201
Title: Coexistence of PIK3CA and other oncogene mutations in lung adenocarcinoma-rationale for comprehensive mutation profiling.
Journal: Molecular cancer therapeutics 20120201
Title: Cooperation between c-Met and focal adhesion kinase family members in medulloblastoma and implications for therapy.
Journal: Molecular cancer therapeutics 20120201
Title: Crizotinib: a drug that crystallizes a unique molecular subset of non-small-cell lung cancer.
Journal: Expert review of anticancer therapy 20120201
Title: Recent advances in pathway-targeted cancer drug therapies emerging from cancer genome analysis.
Journal: Current opinion in genetics & development 20120201
Title: ROS1 gene rearrangement is identified in NSCLC.
Journal: Cancer discovery 20120201
Title: Rapid radiographic and clinical improvement after treatment of a MET-amplified recurrent glioblastoma with a mesenchymal-epithelial transition inhibitor.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120120
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Journal: Journal of the National Cancer Institute 20120118
Title: ALK gene amplified in most inflammatory breast cancers.
Journal: Journal of the National Cancer Institute 20120118
Title: Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathway.
Journal: Cancer cell 20120117
Title: 7,8-dichloro-1-oxo-β-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes.
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Title: Challenges ahead for companion diagnostics.
Journal: Journal of the National Cancer Institute 20120104
Title: ALK fusion gene positive lung cancer and 3 cases treated with an inhibitor for ALK kinase activity.
Journal: Lung cancer (Amsterdam, Netherlands) 20120101
Title: More than just an oncogene translocation and a kinase inhibitor: Kevin's story.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120101
Title: Rhus verniciflua stokes against advanced cancer: a perspective from the Korean Integrative Cancer Center.
Journal: Journal of biomedicine & biotechnology 20120101
Title: Crizotinib: in locally advanced or metastatic non-small cell lung cancer.
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Title: Drug development: portals of discovery.
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Title: Evaluating translocation gene fusions by SNP array data.
Journal: Cancer informatics 20120101
Title: Ancillary testing in lung cancer diagnosis.
Journal: Pulmonary medicine 20120101
Title: Personalized therapy of lung cancer.
Journal: Onkologie 20120101
Title: STAT3 is activated by JAK2 independent of key oncogenic driver mutations in non-small cell lung carcinoma.
Journal: PloS one 20120101
Title: KLC1-ALK: a novel fusion in lung cancer identified using a formalin-fixed paraffin-embedded tissue only.
Journal: PloS one 20120101
Title: ALK-activating homologous mutations in LTK induce cellular transformation.
Journal: PloS one 20120101
Title: A novel classification of lung cancer into molecular subtypes.
Journal: PloS one 20120101
Title: Companion diagnostics: changing patient management.
Journal: Ecancermedicalscience 20120101
Title: Anaplastic lymphoma kinase-positive large B-cell lymphoma: an underrecognized aggressive lymphoma.
Journal: Advances in hematology 20120101
Title: Internalization and down-regulation of the ALK receptor in neuroblastoma cell lines upon monoclonal antibodies treatment.
Journal: PloS one 20120101
Title: Novel therapies for aggressive B-cell lymphoma.
Journal: Advances in hematology 20120101
Title: ALK Signaling and Target Therapy in Anaplastic Large Cell Lymphoma.
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Title: ALK Inhibitors, a Pharmaceutical Perspective.
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Title: A Screening Method for the ALK Fusion Gene in NSCLC.
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Title: [Will targeted therapies replace chemotherapy?].
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Title: Targeted therapies in sarcomas: challenging the challenge.
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Title: Predictive role of computer simulation in assessing signaling pathways of crizotinib-treated A549 lung cancer cells.
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Title: Brentuximab vedotin and crizotinib in anaplastic large-cell lymphoma.
Journal: Cancer journal (Sudbury, Mass.) 20120101
Title: EML4-ALK-positive non-small cell lung cancer in a patient treated with azathioprine for ulcerative colitis.
Journal: Tumori 20120101
Title: MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20111220
Title: MET signaling pathway: a rational target for cancer therapy.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20111220
Title: Activating ALK mutations found in neuroblastoma are inhibited by Crizotinib and NVP-TAE684.
Journal: The Biochemical journal 20111215
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Journal: ACS medicinal chemistry letters 20111208
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Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20111201
Title: Crizotinib-resistant mutants of EML4-ALK identified through an accelerated mutagenesis screen.
Journal: Chemical biology & drug design 20111201
Title: Asymptomatic profound sinus bradycardia (heart rate ≤45) in non-small cell lung cancer patients treated with crizotinib.
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Title: Emerging importance of ALK in neuroblastoma.
Journal: Seminars in cancer biology 20111001
Title: Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK).
Journal: Journal of medicinal chemistry 20110922
Title: 9-substituted 6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazoles as highly selective and potent anaplastic lymphoma kinase inhibitors.
Journal: Journal of medicinal chemistry 20110922
Title: A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors.
Journal: Cancer research 20110915
Title: Anaplastic lymphoma kinase in human cancer.
Journal: Journal of molecular endocrinology 20110801
Title: Detection of ALK gene rearrangement in non-small cell lung cancer: a comparison of fluorescence in situ hybridization and chromogenic in situ hybridization with correlation of ALK protein expression.
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20110801
Title: Synthesis of an aryloxy oxo pyrimidinone library that displays ALK-selective inhibition.
Journal: Bioorganic & medicinal chemistry letters 20110801
Title: Differential (18)F-FDG and 3'-deoxy-3'-(18)F-fluorothymidine PET responses to pharmacologic inhibition of the c-MET receptor in preclinical tumor models.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20110801
Title: Favorable response to crizotinib in three patients with echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase fusion-type oncogene-positive non-small cell lung cancer.
Journal: Cancer science 20110801
Title: Receptor kinase inhibitors target NSCLC: two antibodies and a small-molecule MET inhibitor.
Journal: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 20110801
Title: Crizotinib: an anaplastic lymphoma kinase inhibitor.
Journal: Future oncology (London, England) 20110801
Title: Phase 1 clinical trials for sarcomas: the cutting edge.
Journal: Current opinion in oncology 20110701
Title: [Molecular targeted drugs against ALK fusions].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20110701
Title: The orally bioavailable met inhibitor PF-2341066 inhibits osteosarcoma growth and osteolysis/matrix production in a xenograft model.
Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20110601
Title: [What choice of first-line treatment?].
Journal: Revue de pneumologie clinique 20110601
Title: [What is the best sequence of treatment for patients with EGFR mutations?].
Journal: Revue de pneumologie clinique 20110601
Title: [Biomarkers and targeted therapies in non-small cell lung cancer: present and future treatments].
Journal: Revue de pneumologie clinique 20110601
Title: ALK-targeted therapy for lung cancer: ready for prime time.
Journal: Oncology (Williston Park, N.Y.) 20110601
Title: CSF concentration of the anaplastic lymphoma kinase inhibitor crizotinib.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110520
Title: Pulmonary inflammatory myofibroblastic tumor expressing a novel fusion, PPFIBP1-ALK: reappraisal of anti-ALK immunohistochemistry as a tool for novel ALK fusion identification.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20110515
Title: Virtual screening and further development of novel ALK inhibitors.
Journal: Bioorganic & medicinal chemistry 20110515
Title: Therapeutic strategies to overcome crizotinib resistance in non-small cell lung cancers harboring the fusion oncogene EML4-ALK.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20110503
Title: Activity of crizotinib (PF02341066), a dual mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK) inhibitor, in a non-small cell lung cancer patient with de novo MET amplification.
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20110501
Title: Genotype-driven therapies for non-small cell lung cancer: focus on EGFR, KRAS and ALK gene abnormalities.
Journal: Therapeutic advances in medical oncology 20110501
Title: Targeting anaplastic lymphoma kinase in lung cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20110415
Title: Synthesis and c-Met kinase inhibition of 3,5-disubstituted and 3,5,7-trisubstituted quinolines: identification of 3-(4-acetylpiperazin-1-yl)-5-(3-nitrobenzylamino)-7- (trifluoromethyl)quinoline as a novel anticancer agent.
Journal: Journal of medicinal chemistry 20110414
Title: Anaplastic lymphoma kinase gene rearrangements in non-small cell lung cancer are associated with prolonged progression-free survival on pemetrexed.
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20110401
Title: Potential therapeutic strategies to overcome acquired resistance to BRAF or MEK inhibitors in BRAF mutant cancers.
Journal: Oncotarget 20110401
Title: Early accelerated approval for highly targeted cancer drugs.
Journal: The New England journal of medicine 20110324
Title: NSCLC drug targets acquire new visibility.
Journal: Journal of the National Cancer Institute 20110302
Title: Prediction of oral pharmacokinetics of cMet kinase inhibitors in humans: physiologically based pharmacokinetic model versus traditional one-compartment model.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110301
Title: Crizotinib for EML4-ALK positive lung adenocarcinoma: a hope for the advanced disease? Evaluation of Kwak EL, Bang YJ, Camidge DR, et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med 2010;363(18):1693-703.
Journal: Expert opinion on therapeutic targets 20110301
Title: Personalizing therapy with targeted agents in non-small cell lung cancer.
Journal: Oncotarget 20110301
Title: New targets in advanced NSCLC: EML4-ALK.
Journal: Clinical advances in hematology & oncology : H&O 20110301
Title: Crizotinib in anaplastic large-cell lymphoma.
Journal: The New England journal of medicine 20110224
Title: More on crizotinib.
Journal: The New England journal of medicine 20110224
Title: More on crizotinib.
Journal: The New England journal of medicine 20110224
Title: More on crizotinib.
Journal: The New England journal of medicine 20110224
Title: Distinct interactions between c-Src and c-Met in mediating resistance to c-Src inhibition in head and neck cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20110201
Title: Multiple mutations and bypass mechanisms can contribute to development of acquired resistance to MET inhibitors.
Journal: Cancer research 20110201
Title: Comparison of 2 cell-based phosphoprotein assays to support screening and development of an ALK inhibitor.
Journal: Journal of biomolecular screening 20110201
Title: Kinetic control of protonation in electrospray ionization.
Journal: Journal of the American Society for Mass Spectrometry 20110201
Title: Summary of presentations from the 46th Annual Meeting of the American Society of Clinical Oncology: focus on non-small cell lung cancer (2010).
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20110101
Title: MET inhibitors: translating from bench to bedside.
Journal: The Lancet. Oncology 20110101
Title: Gastrointestinal Mesenchymal Neoplasms other than Gastrointestinal Stromal Tumors: Focusing on Their Molecular Aspects.
Journal: Pathology research international 20110101
Title: Targeted therapies and other agents as first-line maintenance and beyond: particular benefit in pulmonary adenocarcinoma patients.
Journal: Current medicinal chemistry 20110101
Title: Wnt signaling and colon carcinogenesis: beyond APC.
Journal: Journal of carcinogenesis 20110101
Title: Novel targeted therapeutics: inhibitors of MDM2, ALK and PARP.
Journal: Journal of hematology & oncology 20110101
Title: Target therapies in lung cancer.
Journal: Journal of biomedicine & biotechnology 20110101
Title: Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer.
Journal: PloS one 20110101
Title: Advances in fine needle aspiration cytology for the diagnosis of pulmonary carcinoma.
Journal: Pathology research international 20110101
Title: From the bench to bedside: biological and methodology considerations for the future of companion diagnostics in nonsmall cell lung cancer.
Journal: Pathology research international 20110101
Title: Transglutaminase 2 as an independent prognostic marker for survival of patients with non-adenocarcinoma subtype of non-small cell lung cancer.
Journal: Molecular cancer 20110101
Title: Resistance to cancer treatment: the role of somatic genetic events and the challenges for targeted therapies.
Journal: Frontiers in pharmacology 20110101
Title: ALK and NSCLC: Targeted therapy with ALK inhibitors.
Journal: F1000 medicine reports 20110101
Title: Signatures of drug sensitivity in nonsmall cell lung cancer.
Journal: International journal of proteomics 20110101
Title: Spectrum of oncogenic driver mutations in lung adenocarcinomas from East Asian never smokers.
Journal: PloS one 20110101
Title: Crizotinib: a novel and first-in-class multitargeted tyrosine kinase inhibitor for the treatment of anaplastic lymphoma kinase rearranged non-small cell lung cancer and beyond.
Journal: Drug design, development and therapy 20110101
Title: New drug therapies, dedicated specialists and desperately-ill patients-but who will fly the flag for service developments in lung cancer as NHS budgets come under pressure?
Journal: Ecancermedicalscience 20110101
Title: An update on the management of peripheral T-cell lymphoma and emerging treatment options.
Journal: Journal of blood medicine 20110101
Title: Personalized therapy for non-small cell lung cancer: which drug for which patient?
Journal: Seminars in thoracic and cardiovascular surgery 20110101
Title: Anaplastic Lymphoma Kinase: role in specific tumours, and development of small molecule inhibitors for cancer therapy.
Journal: Cancer letters 20101228
Title: The neuroblastoma-associated F1174L ALK mutation causes resistance to an ALK kinase inhibitor in ALK-translocated cancers.
Journal: Cancer research 20101215
Title: ALK inhibition for non-small cell lung cancer: from discovery to therapy in record time.
Journal: Cancer cell 20101214
Title: New drugs in advanced non-small-cell lung cancer: searching for the correct clinical development.
Journal: Expert opinion on investigational drugs 20101201
Title: Parameters for individualizing systemic therapy in non-small cell lung cancer.
Journal: Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 20101201
Title: Rapid and dramatic radiographic and clinical response to an ALK inhibitor (crizotinib, PF02341066) in an ALK translocation-positive patient with non-small cell lung cancer.
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20101201
Title: Trial watch: success for crizotinib in ALK-driven cancer.
Journal: Nature reviews. Drug discovery 20101201
Title: Crizotinib, a small-molecule dual inhibitor of the c-Met and ALK receptor tyrosine kinases.
Journal: Current opinion in investigational drugs (London, England : 2000) 20101201
Title: [Following communications made at American Society of Clinical Oncology 2010, what will change our practice? The point of view of the editorial board of Bulletin du Cancer].
Journal: Bulletin du cancer 20101201
Title: Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry.
Journal: Chemistry & biology 20101124
Title: Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer.
Journal: The New England journal of medicine 20101028
Title: Crizotinib in ALK-rearranged inflammatory myofibroblastic tumor.
Journal: The New England journal of medicine 20101028
Title: EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors.
Journal: The New England journal of medicine 20101028
Title: Crizotinib--latest champion in the cancer wars?
Journal: The New England journal of medicine 20101028
Title: Exciting new targets in lung cancer therapy: ALK, IGF-1R, HDAC, and Hh.
Journal: Current treatment options in oncology 20100601
Title: Gender specific drug metabolism of PF-02341066 in rats--role of sulfoconjugation.
Journal: Current drug metabolism 20100501
Title: Discovery of 6-benzyloxyquinolines as c-Met selective kinase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20100215
Title: Acquired resistance of non-small cell lung cancer cells to MET kinase inhibition is mediated by a switch to epidermal growth factor receptor dependency.
Journal: Cancer research 20100215
Title: An orally available small-molecule inhibitor of c-Met, PF-2341066, reduces tumor burden and metastasis in a preclinical model of ovarian cancer metastasis.
Journal: Neoplasia (New York, N.Y.) 20100101
Title: Efficacy of c-Met inhibitor for advanced prostate cancer.
Journal: BMC cancer 20100101
Title: Deciding priorities in Pharma.
Journal: Breast cancer research : BCR 20100101
Title: HGF and c-Met participate in paracrine tumorigenic pathways in head and neck squamous cell cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090601
Title: An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms.
Journal: Cancer research 20070501
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