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Home Other Building Blocks 878385-84-3
878385-84-3,MFCD19443645
Catalog No.:AA01ENSG

878385-84-3 | AZD-5069

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$48.00   $33.00
- +
5mg
98%
in stock  
$82.00   $57.00
- +
10mg
98%
in stock  
$139.00   $97.00
- +
25mg
98%
in stock  
$267.00   $187.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01ENSG
Chemical Name:
AZD-5069
CAS Number:
878385-84-3
Molecular Formula:
C18H22F2N4O5S2
Molecular Weight:
476.5179
MDL Number:
MFCD19443645
SMILES:
OC[C@@H]([C@H](Oc1nc(SCc2cccc(c2F)F)nc(c1)NS(=O)(=O)N1CCC1)C)O
Properties
Computed Properties
 
Complexity:
670  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
12  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
10  
XLogP3:
1.5  

Downstream Synthesis Route

[1]CurrentPatentAssignee:ASTRAZENECAPLC-WO2006/24823,2006,A1Locationinpatent:Page/Pagecolumn92

[1]Hickey,MichaelJ.;Allen,PaulH.;Caffrey,Moya;Hansen,Peter;Kingston,LeeP.;Wilkinson,DavidJ.[Journaloflabelledcompoundsandradiopharmaceuticals,2016,p.432-438]

[1]Hickey,MichaelJ.;Allen,PaulH.;Caffrey,Moya;Hansen,Peter;Kingston,LeeP.;Wilkinson,DavidJ.[Journaloflabelledcompoundsandradiopharmaceuticals,2016,p.432-438]

[1]Hickey,MichaelJ.;Allen,PaulH.;Caffrey,Moya;Hansen,Peter;Kingston,LeeP.;Wilkinson,DavidJ.[Journaloflabelledcompoundsandradiopharmaceuticals,2016,p.432-438]

Literature

Title: A randomised, placebo-controlled study of the CXCR2 antagonist AZD5069 in bronchiectasis.

Journal: The European respiratory journal 20151001

Title: Pharmacological characterization of AZD5069, a slowly reversible CXC chemokine receptor 2 antagonist.

Journal: The Journal of pharmacology and experimental therapeutics 20150501

Title: Norman P. Evidence on the identity of the CXCR2 antagonist AZD-5069. Expert Opin Ther Pat. 2013 Jan;23(1):113-7.

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SDS
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