Home Other Building Blocks 878672-00-5
878672-00-5,MFCD22572730
Catalog No.:AA00GR87

878672-00-5 | Lesinurad

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$6.00   $4.00
- +
5mg
98%
in stock  
$8.00   $6.00
- +
10mg
98%
in stock  
$11.00   $8.00
- +
50mg
98%
in stock  
$15.00   $11.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00GR87
Chemical Name:
Lesinurad
CAS Number:
878672-00-5
Molecular Formula:
C17H14BrN3O2S
Molecular Weight:
404.2810
MDL Number:
MFCD22572730
SMILES:
OC(=O)CSc1nnc(n1c1ccc(c2c1cccc2)C1CC1)Br
Properties
Computed Properties
 
Complexity:
479  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
4.7  

Downstream Synthesis Route

[1]CurrentPatentAssignee:ASTRAZENECAPLC-WO2009/70740,2009,A2Locationinpatent:Page/Pagecolumn91

[2]CurrentPatentAssignee:ASTRAZENECAPLC-WO2006/26356,2006,A2Locationinpatent:Page/Pagecolumn24

[3]CurrentPatentAssignee:ASTRAZENECAPLC-WO2011/85009,2011,A2Locationinpatent:Page/Pagecolumn38-39

[4]Lei,Xiaofang;Wang,Yuanyuan;Fan,Erkang;Sun,Zhihua[OrganicLetters,2019,vol.21,#5,p.1484-1487]

[5]CurrentPatentAssignee:SHENZHENDONGYANGGUANGINDUSTRIALDEVELOPMENTCOLTD-WO2014/198241,2014,A1Locationinpatent:Paragraph077-078

[6]CurrentPatentAssignee:SHANDONGUNIVERSITY-CN105566237,2016,ALocationinpatent:Paragraph0075;0076;0077

[7]CurrentPatentAssignee:CHENGDUMIRACLEPHARMACEUTICAL-CN107955029,2018,ALocationinpatent:Paragraph0064-0066;0080-0082;0096-0098

[8]Li,Yaoqi;Sun,Zhihua[Heterocycles,2020,vol.100,#7]

[9]CurrentPatentAssignee:ASTRAZENECAPLC-WO2014/8295,2014,A1Locationinpatent:Paragraph0340-0344

[10]CurrentPatentAssignee:ASTRAZENECAPLC-WO2014/8295,2014,A1

[11]CurrentPatentAssignee:CHINARESOURCESNATIONALCORPORATION-CN105985295,2016,ALocationinpatent:Paragraph0045;0046;0047

[12]CurrentPatentAssignee:SHANGHAIJINGXINBIOLOGICALMEDICAL;XINCHANGKANGLECHEMICALSCO.,LTD.-CN107098866,2017,A

[13]CurrentPatentAssignee:HUNANOUYABIOLOGICAL-CN106632108,2017,ALocationinpatent:Paragraph0057;0069;0079;0080

[14]CurrentPatentAssignee:ZhaoTiantian-CN107915689,2018,ALocationinpatent:Paragraph0011;0012;0013

[15]CurrentPatentAssignee:BEIJINGXINKAIYUANPHARMACEUTICALSTECHHAINANBRANCH-CN111153862,2020,ALocationinpatent:Paragraph0032-0033

[16]CurrentPatentAssignee:ZHEJIANGHUAHAIPHARMACEUTICALCO.,LTD.-CN111320588,2020,ALocationinpatent:Paragraph0034-0037

[17]Zhao,Tong;Meng,Qing;Sun,Zhuosen;Chen,Yanyu;Ai,Wei;Zhao,Zean;Kang,Dongwei;Dong,Yue;Liang,Ruipeng;Wu,Ting;Pang,Jianxin;Liu,Xinyong;Zhan,Peng[JournalofMedicinalChemistry,2020,vol.63,#19,p.10829-10854]

[18]CurrentPatentAssignee:CHINARESOURESSAIKEPHARMACEUTICAL;CHINARESOURCESNATIONALCORPORATION-US2021/53928,2021,A1

2-5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylsulfanyl}aceticacid 
  1151516-14-1 

[1]Patent:WO2009/70740,2009,A2.Locationinpatent:Page/Pagecolumn91-92

[2]Patent:WO2011/85009,2011,A2.Locationinpatent:Page/Pagecolumn34-35

[3]Patent:WO2018/85932,2018,A1.Locationinpatent:Paragraph0079

[4]Patent:CN105985295,2016,A.Locationinpatent:Paragraph0070;0071

[5]Patent:CN104447589,2017,B

878672-00-5   
CASUnavailable 

[1]CurrentPatentAssignee:ASTRAZENECAPLC-WO2009/70740,2009,A2Locationinpatent:Page/Pagecolumn92

[2]CurrentPatentAssignee:CRYSTALPHARMATECHCO.,LTD.;SUZHOUPENGXUPHARMATECHCO.,LTD.-WO2015/95703,2015,A1Locationinpatent:Page/Pagecolumn12;13

[3]CurrentPatentAssignee:CHINARESOURCESNATIONALCORPORATION-CN105985295,2016,ALocationinpatent:Paragraph0072;0073

[1]CurrentPatentAssignee:ASTRAZENECAPLC-WO2009/70740,2009,A2Locationinpatent:Page/Pagecolumn92

[1]CurrentPatentAssignee:ASTRAZENECAPLC-WO2009/70740,2009,A2Locationinpatent:Page/Pagecolumn79-80

[2]CurrentPatentAssignee:ASTRAZENECAPLC-WO2011/85009,2011,A2Locationinpatent:Page/Pagecolumn35

Literature

Title: Lesinurad: First Global Approval.

Journal: Drugs 20160301

Title: Gout therapeutics: new drugs for an old disease.

Journal: Lancet (London, England) 20110108

Title: Shen Z, et al. In Vitro and In Vivo Interaction Studies Between Lesinurad, a Selective Urate Reabsorption Inhibitor, and Major Liver or Kidney Transporters. Clin Drug Investig. 2016 Jun;36(6):443-52.

Title: Sattui SE, et al. Treatment of hyperuricemia in gout: current therapeutic options, latest developments and clinical implications. Ther Adv Musculoskelet Dis. 2016 Aug;8(4):145-59.

Title: L.Yeh, et al. RDEA594, a potential uric acid lowering agent througn inhibition of uric acid reuptake ,shows better pharmacokinetics rhan its prodrug RDEA806. 2008 ACR/ARHP Annual Scientific Meeting, 24-29 October 2008, USA.

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