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87893-54-7,MFCD00065805
Catalog No.:AA004E11

87893-54-7 | Prosta-5,9,12-trien-1-oicacid, 15-hydroxy-11-oxo-, (5Z,12E,15S)-

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1mg
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA004E11
Chemical Name:
Prosta-5,9,12-trien-1-oicacid, 15-hydroxy-11-oxo-, (5Z,12E,15S)-
CAS Number:
87893-54-7
Molecular Formula:
C20H30O4
Molecular Weight:
334.4498
MDL Number:
MFCD00065805
SMILES:
CCCCC[C@@H](C/C=C/1\[C@@H](C/C=C\CCCC(=O)O)C=CC1=O)O
Properties
Properties
 
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
488  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
2  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
12  
XLogP3:
3.9  

Literature

Title: Prostaglandin D2 toxicity in primary neurons is mediated through its bioactive cyclopentenone metabolites.

Journal: Neurotoxicology 20131201

Title: Neuroprotective cyclopentenone prostaglandins up-regulate neurotrophic factors in C6 glioma cells.

Journal: Brain research 20121030

Title: Targeting of histone acetyltransferase p300 by cyclopentenone prostaglandin Δ(12)-PGJ(2) through covalent binding to Cys(1438).

Journal: Chemical research in toxicology 20120220

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Chronic COX-2 inhibition reduces medullary HSP70 expression and induces papillary apoptosis in dehydrated rats.

Journal: Kidney international 20040201

Title: Expression and molecular pharmacology of the mouse CRTH2 receptor.

Journal: The Journal of pharmacology and experimental therapeutics 20030801

Title: Delta 12-prostaglandin J2, a plasma metabolite of prostaglandin D2, causes eosinophil mobilization from the bone marrow and primes eosinophils for chemotaxis.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20030501

Title: Molecular pharmacology of the human prostaglandin D2 receptor, CRTH2.

Journal: British journal of pharmacology 20021201

Title: Prostaglandin D2 and its metabolites induce caspase-dependent granulocyte apoptosis that is mediated via inhibition of I kappa B alpha degradation using a peroxisome proliferator-activated receptor-gamma-independent mechanism.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20020615

Title: Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist.

Journal: British journal of pharmacology 19980401

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Tags:87893-54-7 Molecular Formula|87893-54-7 MDL|87893-54-7 SMILES|87893-54-7 Prosta-5,9,12-trien-1-oicacid, 15-hydroxy-11-oxo-, (5Z,12E,15S)-