Home Other Building Blocks 879089-64-2
879089-64-2,MFCD01862675
Catalog No.:AA00GXPK

879089-64-2 | CP-93129 Dihydrochloride Hydrate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$48.00   $33.00
- +
5mg
≥95%
in stock  
$166.00   $116.00
- +
10mg
≥95%
in stock  
$235.00   $164.00
- +
25mg
≥95%
in stock  
$525.00   $367.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00GXPK
Chemical Name:
CP-93129 Dihydrochloride Hydrate
CAS Number:
879089-64-2
Molecular Formula:
C12H15Cl2N3O
Molecular Weight:
288.1730
MDL Number:
MFCD01862675
SMILES:
O=c1ccc2c([nH]1)c(c[nH]2)C1=CCNCC1.Cl.Cl
Properties
Computed Properties
 
Complexity:
361  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
1  

Literature

Title: 5-HT(1B) receptors inhibit glutamate release from primary afferent terminals in rat medullary dorsal horn neurons.

Journal: British journal of pharmacology 20120901

Title: Infralimbic and dorsal raphé microinjection of the 5-HT(1B) receptor agonist CP-93,129: attenuation of aggressive behavior in CFW male mice.

Journal: Psychopharmacology 20120701

Title: A novel mechanism for regulating hepatic glycogen synthesis involving serotonin and cyclin-dependent kinase-5.

Journal: Diabetes 20120101

Title: Social instigation and aggression in postpartum female rats: role of 5-Ht1A and 5-Ht1B receptors in the dorsal raphé nucleus and prefrontal cortex.

Journal: Psychopharmacology 20110201

Title: Progesterone reduces the inhibitory effect of a serotonin 1B receptor agonist on lordosis behavior.

Journal: Pharmacology, biochemistry, and behavior 20101201

Title: Activation of 5-HT1B receptors inhibits the vasodepressor sensory CGRPergic outflow in pithed rats.

Journal: European journal of pharmacology 20100710

Title: Modulatory effects of serotonin on GABAergic synaptic transmission and membrane properties in the deep cerebellar nuclei.

Journal: Journal of neurophysiology 20090301

Title: Social instigation and aggressive behavior in mice: role of 5-HT1A and 5-HT1B receptors in the prefrontal cortex.

Journal: Psychopharmacology 20081201

Title: 5-HT(1A) and 5-HT(1B) receptors in the ventrolateral striatum differentially modulate apomorphine-induced jaw movements in rats.

Journal: Journal of oral science 20081201

Title: Serotonin 1B receptor modulates frequency response curves and spectral integration in the inferior colliculus by reducing GABAergic inhibition.

Journal: Journal of neurophysiology 20080901

Title: Anti-aggressive effects of agonists at 5-HT1B receptors in the dorsal raphe nucleus of mice.

Journal: Psychopharmacology 20070801

Title: Agonist-mediated regulation of presynaptic receptor function during development of rat septal neurons in culture.

Journal: Journal of neurochemistry 20070801

Title: Activity-dependent depression of local excitatory connections in the CA1 region of mouse hippocampus.

Journal: Journal of neurophysiology 20070601

Title: Effect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in rats.

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20070601

Title: Presynaptic modulation of 5-HT release in the rat septal region.

Journal: Neuroscience 20070511

Title: Activation of 5-HT1B and 5-HT1D receptors in the rat nucleus tractus solitarius: opposing action on neurones that receive an excitatory vagal C-fibre afferent input.

Journal: British journal of pharmacology 20070401

Title: Different serotonin receptor agonists have distinct effects on sound-evoked responses in inferior colliculus.

Journal: Journal of neurophysiology 20061101

Title: 5-HT1B receptor-mediated presynaptic inhibition at the calyx of Held of immature rats.

Journal: The European journal of neuroscience 20061001

Title: Presynaptic serotonergic modulation of 5-HT and acetylcholine release in the hippocampus and the cortex of 5-HT1B-receptor knockout mice.

Journal: Brain research bulletin 20060615

Title: 5-HT1B receptor-mediated presynaptic inhibition of GABA release in the suprachiasmatic nucleus.

Journal: Journal of neurophysiology 20050601

Title: Role of 5-HT1A and 5-HT1B receptors in the antinociceptive effect of tramadol.

Journal: European journal of pharmacology 20050321

Title: Involvement of spinal serotonin receptors in the regulation of intraspinal acetylcholine release.

Journal: European journal of pharmacology 20050221

Title: Selective 5-HT1B receptor agonist reduces serotonin synthesis following acute, and not chronic, drug administration: results of an autoradiographic study.

Journal: Neurochemistry international 20050201

Title: Autoradiographic characterisation of [35S]GTPgammaS binding stimulation mediated by 5-HT1B receptor in postmortem human brain.

Journal: Neuropharmacology 20050101

Title: Growth inhibitory effect of doxazosin on prostate and bladder cancer cells. Is the serotonin receptor pathway involved?

Journal: Anticancer research 20050101

Title: Involvement of 5-HT1B receptors within the ventral tegmental area in regulation of mesolimbic dopaminergic neuronal activity via GABA mechanisms: a study with dual-probe microdialysis.

Journal: Brain research 20040917

Title: Effects of 5-HT1B receptor ligands microinjected into the ventral tegmental area on the locomotor and sensitizating effects of cocaine in rats.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20040501

Title: In vivo efflux of serotonin in the dorsal raphe nucleus of 5-HT1A receptor knockout mice.

Journal: Journal of neurochemistry 20040301

Title: 5-Hydroxytryptamine 1B receptors mediate presynaptic inhibition of monosynaptic IPSC in the rat dorsolateral septal nucleus.

Journal: Neuroscience research 20040301

Title: Further characterization of the 5-HT1 receptors mediating cardiac sympatho-inhibition in pithed rats: pharmacological correlation with the 5-HT1B and 5-HT1D subtypes.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20040201

Title: Role of 5-HT1B receptors in the regulation of extracellular serotonin and dopamine in the dorsal striatum of mice.

Journal: European journal of pharmacology 20030822

Title: Differential involvement of central 5-HT1B and 5-HT3 receptor subtypes in the antinociceptive effect of paracetamol.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20030801

Title: S+ -flurbiprofen but not 5-HT1 agonists suppress basal and stimulated CGRP and PGE2 release from isolated rat dura mater.

Journal: Pain 20030601

Title: Presynaptic modulation of acetylcholine, noradrenaline, and serotonin release in the hippocampus of aged rats with various levels of memory impairments.

Journal: Brain research bulletin 20030515

Title: Presynaptic regulation of neurotransmitter release in the cortex of aged rats with differential memory impairments.

Journal: Pharmacology, biochemistry, and behavior 20030401

Title: The role of 5-HT1A/B autoreceptors in the antinociceptive effect of systemic administration of acetaminophen.

Journal: Anesthesiology 20030301

Title: Neurotransmitter release and its presynaptic modulation in the rat hippocampus after selective damage to cholinergic or/and serotonergic afferents.

Journal: Brain research bulletin 20030130

Title: Arterial expression of 5-HT2B and 5-HT1B receptors during development of DOCA-salt hypertension.

Journal: BMC pharmacology 20030101

Title: Activation of 5HT1B receptors inhibits glycinergic synaptic inputs to mammalian motoneurons during postnatal development.

Journal: Brain research 20021129

Title: 5,7-Dihydroxytryptamine lesions enhance and serotonergic grafts normalize the evoked overflow of acetylcholine in rat hippocampal slices.

Journal: The European journal of neuroscience 20021101

Title: Effects of 5-HT(1B) receptor ligands microinjected into the accumbal shell or core on the sensitization to cocaine in rats.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20021001

Title: Effects of serotonin (5-HT)(1B) receptor ligands, microinjected into accumbens subregions, on cocaine discrimination in rats.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20020901

Title: Effects of 5-HT1B receptor ligands microinjected into the accumbal shell or core on the cocaine-induced locomotor hyperactivity in rats.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20020901

Title: Extracellular serotonin in the prefrontal cortex is limited through terminal 5-HT(1B) autoreceptors: a microdialysis study in knockout mice.

Journal: Psychopharmacology 20020801

Title: Subthalamic 5-HT(1A) and 5-HT(1B) receptor modulation of RU 24969-induced behavioral profile in rats.

Journal: Pharmacology, biochemistry, and behavior 20020401

Title: Parabrachial infusion of D-fenfluramine reduces food intake. Blockade by the 5-HT(1B) antagonist SB-216641.

Journal: Pharmacology, biochemistry, and behavior 20020401

Title: Activation of 5-HT(1B) receptors in the nucleus accumbens reduces self-administration of amphetamine on a progressive ratio schedule.

Journal: Pharmacology, biochemistry, and behavior 20020401

Title: The effects of selective serotonin reuptake inhibitors on extracellular 5-HT levels in the hippocampus of 5-HT(1B) receptor knockout mice.

Journal: European journal of pharmacology 20020329

Title: Activity-dependent presynaptic effect of serotonin 1B receptors on the somatosensory thalamocortical transmission in neonatal mice.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20020201

Title: Modification of serotonin neuron properties in mice lacking 5-HT1A receptors.

Journal: European journal of pharmacology 20020125

Title: Effect of intra-tegmental microinjections of 5-HT1B receptor ligands on the amphetamine-induced locomotor hyperactivity in rats.

Journal: Polish journal of pharmacology 20020101

Title: Serotonin-1B receptor-mediated inhibition of [(3)H]GABA release from rat ventral tegmental area slices.

Journal: Journal of neurochemistry 20011101

Title: The role of 5-HT1B receptors in the regulation of serotonin cell firing and release in the rat brain.

Journal: Journal of neurochemistry 20011001

Title: Enhanced contraction to 5-hydroxytryptamine is not due to 'unmasking' of 5-hydroxytryptamine(1b) receptors in the mesenteric artery of the deoxycorticosterone acetate-salt rat.

Journal: Hypertension (Dallas, Tex. : 1979) 20011001

Title: Effects of 5-HT2 and 5-HT3 receptors on the modulation of nociceptive transmission in rat spinal cord according to the formalin test.

Journal: European journal of pharmacology 20010713

Title: Activation of 5-HT(1B/1D) receptors in the mesolimbic dopamine system increases dopamine release from the nucleus accumbens: a microdialysis study.

Journal: European journal of pharmacology 20010420

Title: Multiple 5-HT(1) autoreceptor subtypes govern serotonin release in dorsal and median raphé nuclei.

Journal: Neuropharmacology 20010301

Title: Serotonin1B receptor ligands in the nucleus accumbens shell do not affect the discriminative stimulus effects of amphetamine in rats.

Journal: Polish journal of pharmacology 20010101

Title: Serotonin1B receptor stimulation enhances cocaine reinforcement.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 19981201

Title: CP-93,129, sumatriptan, dihydroergotamine block c-fos expression within rat trigeminal nucleus caudalis caused by chemical stimulation of the meninges.

Journal: British journal of pharmacology 19920601

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 879089-64-2
Tags:879089-64-2 Molecular Formula|879089-64-2 MDL|879089-64-2 SMILES|879089-64-2 CP-93129 Dihydrochloride Hydrate