Name: Name:Aurora Kinase Inhibitor III
Brand: AABLOCKS
SKU: AA004HHR
Rating: 90 (10 reviews)

Catalog No.: AA004HHR

879127-16-9 | Aurora Kinase Inhibitor III

Pack Size： 1mg

Purity： 98%

in stock

$15.00 $11.00

Pack Size： 5mg

Purity： 98%

in stock

$37.00 $26.00

Pack Size： 10mg

Purity： 98%

in stock

$55.00 $38.00

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Technical Information

Catalog Number: AA004HHR

Chemical Name: Aurora Kinase Inhibitor III

CAS Number: 879127-16-9

Molecular Formula: C21H18F3N5O

Molecular Weight: 413.3957

MDL Number: MFCD09265250

SMILES: O=C(C1CC1)Nc1cccc(c1)Nc1nccc(n1)Nc1cccc(c1)C(F)(F)F

Properties

Form: Solid

Storage: Light sensitive;Keep in dry area;2-8℃;

Complexity: 586

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 30

Hydrogen Bond Acceptor Count: 8

Hydrogen Bond Donor Count: 3

Isotope Atom Count: 0

Rotatable Bond Count: 6

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 4.5

Literature fold

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal20130415

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology20111101

Title: Identification of new inhibitors of protein kinase R guided by statistical modeling.

Journal: Bioorganic & medicinal chemistry letters20110701

Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

Journal: Proceedings of the National Academy of Sciences of the United States of America20071218

Title: Structural basis for the inhibition of Aurora A kinase by a novel class of high affinity disubstituted pyrimidine inhibitors.

Journal: Bioorganic & medicinal chemistry letters20070201

Title: Tari LW, et al. Structural basis for the inhibition of Aurora A kinase by a novel class of high affinitydisubstituted pyrimidine inhibitors. Bioorg Med Chem Lett. 2007 Feb 1;17(3):688-91.

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