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Home Other Building Blocks 879127-07-8
879127-07-8,MFCD13191284
Catalog No.:AA008C7Q

879127-07-8 | EGFR Inhibitor

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$133.00   $93.00
- +
5mg
99%
in stock  
$293.00   $205.00
- +
25mg
99%
in stock  
$765.00   $535.00
- +
  • Technical Information
  • Properties
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008C7Q
Chemical Name:
EGFR Inhibitor
CAS Number:
879127-07-8
Molecular Formula:
C21H18F3N5O
Molecular Weight:
413.3957
MDL Number:
MFCD13191284
SMILES:
O=C(C1CC1)Nc1cccc(c1)Nc1ncnc(c1)Nc1cccc(c1)C(F)(F)F
Properties
Computed Properties
 
Complexity:
586  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  
XLogP3:
4.5  

Literature

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111101

Title: Cardiac glycosides are potent inhibitors of interferon-β gene expression.

Journal: Nature chemical biology 20110101

Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20071218

Title: Structural basis for the inhibition of Aurora A kinase by a novel class of high affinity disubstituted pyrimidine inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20070201

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SDS
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