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88475-69-8,MFCD00911570
Catalog No.:AA004A82

88475-69-8 | Esuberaprost Sodium

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$193.00   $135.00
- +
5mg
≥98%
in stock  
$772.00   $540.00
- +
10mg
≥98%
in stock  
$1,350.00   $945.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA004A82
Chemical Name:
Esuberaprost Sodium
CAS Number:
88475-69-8
Molecular Formula:
C24H29NaO5
Molecular Weight:
420.4738
MDL Number:
MFCD00911570
SMILES:
CC#CCC(C(/C=C/C1C(O)CC2C1c1cccc(c1O2)CCCC(=O)[O-])O)C.[Na+]
Properties
Properties
 
Form:
Solid  
MP:
>110ºC (dec.)  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
665  
Covalently-Bonded Unit Count:
2  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
8  
Undefined Atom Stereocenter Count:
6  

Literature

Title: Prostacyclin mimetics afford protection against lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.

Journal: Toxicology and applied pharmacology 20171101

Title: Prostaglandin I(2) analogues enhance already exuberant Th17 cell responses in systemic sclerosis.

Journal: Annals of the rheumatic diseases 20121201

Title: Pathways in pulmonary arterial hypertension: the future is here.

Journal: European respiratory review : an official journal of the European Respiratory Society 20121201

Title: Beraprost sodium, a stable prostacyclin analogue, improves insulin resistance in high-fat diet-induced obese mice.

Journal: The Journal of endocrinology 20120601

Title: The effect of renal administration of a selective cyclooxygenase-2 inhibitor or stable prostaglandin I2 analog on the progression of sclerotic glomerulonephritis in rats.

Journal: Clinical and experimental nephrology 20120401

Title: A microchip flow-chamber system for quantitative assessment of the platelet thrombus formation process.

Journal: Microvascular research 20120301

Title: Formal synthesis of antiplatelet drug, beraprost.

Journal: Organic letters 20120106

Title: Percutaneous transluminal pulmonary angioplasty markedly improves pulmonary hemodynamics and long-term prognosis in patients with chronic thromboembolic pulmonary hypertension.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20120101

Title: Acute decrease of cardio-ankle vascular index with the administration of beraprost sodium.

Journal: Journal of atherosclerosis and thrombosis 20120101

Title: Prostanoid receptors involved in regulation of the beating rate of neonatal rat cardiomyocytes.

Journal: PloS one 20120101

Title: Efficacy, safety, and pharmacokinetics of ambrisentan in Japanese adults with pulmonary arterial hypertension.

Journal: Current medical research and opinion 20110901

Title: Disruption of COX-2 and eNOS does not confer protection from cardiovascular failure in lipopolysaccharide-treated conscious mice and isolated vascular rings.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20110801

Title: Prostaglandin I(2) analogues suppress TNF-α expression in human monocytes via mitogen-activated protein kinase pathway.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20110701

Title: Beraprost enhances the APC function of B cells by upregulating CD86 expression levels.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20110401

Title: Persistent pulmonary hypertension of the newborn successfully treated with beraprost sodium: a retrospective chart review.

Journal: Neonatology 20110101

Title: Effects of beraprost sodium, a prostaglandin I(2) analog, on high glucose-induced proliferation and oxidative stress in a rat glomerular mesangial cell line.

Journal: Pharmacology 20110101

Title: Disproportionate pulmonary hypertension in a patient with early-onset pulmonary emphysema treated with specific drugs for pulmonary arterial hypertension.

Journal: Internal medicine (Tokyo, Japan) 20110101

Title: Initial and programmed combination therapy with oral drugs for severe idiopathic pulmonary arterial hypertension.

Journal: International heart journal 20110101

Title: Successful management of portopulmonary hypertension with beraprost.

Journal: European journal of gastroenterology & hepatology 20101201

Title: The anti-aggregating effect of BAY 41-2272, a stimulator of soluble guanylyl cyclase, requires the presence of nitric oxide.

Journal: British journal of pharmacology 20101101

Title: Selexipag: a selective prostacyclin receptor agonist that does not affect rat gastric function.

Journal: The Journal of pharmacology and experimental therapeutics 20101001

Title: TRA-418, a thromboxane A2 receptor antagonist and prostacyclin receptor agonist, inhibits platelet-leukocyte interaction in human whole blood.

Journal: Thrombosis and haemostasis 20101001

Title: Beraprost sodium, an orally active prostaglandin I(2) analog, improves renal anemia in hemodialysis patients with peripheral arterial disease.

Journal: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 20101001

Title: Neuroprotective properties of prostaglandin I2 IP receptor in focal cerebral ischemia.

Journal: Neuroscience 20100929

Title: Improvement of dyslipidemia in OLETF rats by the prostaglandin I(2) analog beraprost sodium.

Journal: Prostaglandins & other lipid mediators 20100901

Title: Fibroblast-specific expression of AC6 enhances beta-adrenergic and prostacyclin signaling and blunts bleomycin-induced pulmonary fibrosis.

Journal: American journal of physiology. Lung cellular and molecular physiology 20100601

Title: Sildenafil and beraprost combination therapy in patients with pulmonary hypertension undergoing valvular heart surgery.

Journal: The Journal of heart valve disease 20100501

Title: The prostacyclin analog beraprost sodium ameliorates characteristics of metabolic syndrome in obese Zucker (fatty) rats.

Journal: Diabetes 20100401

Title: Comparison of antiplatelet potency of sarpogrelate, aspirin, and beraprost in healthy volunteers according to in-vitro closure time.

Journal: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20100401

Title: Three-year cardiovascular events and disease progress in patients with peripheral arterial disease: results from the Japan Medication Therapy for Peripheral Arterial Disease (J-METHOD).

Journal: International angiology : a journal of the International Union of Angiology 20100401

Title: Orally active prostacyclin analogue for cardiovascular disease.

Journal: International angiology : a journal of the International Union of Angiology 20100401

Title: Novel effects of beraprost sodium on vasculatures.

Journal: International angiology : a journal of the International Union of Angiology 20100401

Title: Genetic polymorphisms of prostacyclin synthase gene and cardiovascular disease.

Journal: International angiology : a journal of the International Union of Angiology 20100401

Title: The efficacy of oral beraprost sodium, a prostaglandin I2 analogue, for treating intermittent claudication in patients with arteriosclerosis obliterans.

Journal: International angiology : a journal of the International Union of Angiology 20100401

Title: A prostacyclin agonist with thromboxane inhibitory activity for airway allergic inflammation in mice.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20100201

Title: A case of isolated peripheral pulmonary artery branch stenosis associated with multiple pulmonary artery aneurysms.

Journal: Internal medicine (Tokyo, Japan) 20100101

Title: Anti-aggregating effect of BAY 58-2667, an activator of soluble guanylyl cyclase.

Journal: Vascular pharmacology 20100101

Title: Treatment of in-stent restenosis with beraprost sodium: an experimental study of short- and intermediate-term effects in dogs.

Journal: Clinical and experimental pharmacology & physiology 20091201

Title: [Current approach to the treatment of pulmonary arterial hypertension and our experience in the Cardiology Department of Medicine Faculty of Ege University].

Journal: Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 20091201

Title: Efficacy of oral sildenafil in a beraprost-treated patient with severe pulmonary hypertension secondary to type I glycogen storage disease.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20091001

Title: PPARdelta-mediated p21/p27 induction via increased CREB-binding protein nuclear translocation in beraprost-induced antiproliferation of murine aortic smooth muscle cells.

Journal: American journal of physiology. Cell physiology 20090801

Title: Effects of long-acting beraprost sodium (TRK-100STP) in Japanese patients with pulmonary arterial hypertension.

Journal: International heart journal 20090701

Title: Protective effect of beraprost sodium, a stable prostacyclin analog, in the development of cigarette smoke extract-induced emphysema.

Journal: American journal of physiology. Lung cellular and molecular physiology 20090401

Title: Effects of a stable prostacyclin analogue beraprost sodium on VEGF and PAI-1 gene expression in vascular smooth muscle cells.

Journal: International journal of cardiology 20090306

Title: The search for an oral prostanoid to treat pulmonary arterial hypertension continues. Are we getting any closer?

Journal: International journal of clinical practice. Supplement 20090301

Title: [Pharmacological profiles and clinical effects of oral sustained release beraprost sodium (Careload LA tablets 60 microg, Berasus LA tablets 60 microg)].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20090201

Title: Amelioration of diabetic nephropathy in OLETF rats by prostaglandin I(2) analog, beraprost sodium.

Journal: American journal of nephrology 20090101

Title: Effects of beraprost sodium, an oral prostaglandin i2 analog, on hemostatic factors and inflammation in chronic peritoneal dialysis patients.

Journal: Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 20090101

Title: Effect of beraprost sodium (BPS) in a new rat partial unilateral ureteral obstruction model.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20090101

Title: Long-term administration of beraprost sodium for pulmonary arterial hypertension associated with congenital heart disease.

Journal: Internal medicine (Tokyo, Japan) 20090101

Title: [Prostacyclin derivatives].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20081101

Title: Evaluation of drug-drug interaction potential of beraprost sodium mediated by P450 in vitro.

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20081001

Title: Successful treatment of a patient with severe pulmonary hypertension due to perivalvular leakage at aortic and mitral positions after aortic and mitral valve replacement.

Journal: General thoracic and cardiovascular surgery 20081001

Title: Adaptive HNE-Nrf2-HO-1 pathway against oxidative stress is associated with acute gastric mucosal lesions.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20080901

Title: [Etiology of iodinated radiocontrast nephrotoxicity and its attenuation by beraprost].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20080701

Title: Prostacyclin analogs stimulate VEGF production from human lung fibroblasts in culture.

Journal: American journal of physiology. Lung cellular and molecular physiology 20080601

Title: [Evidence-based quality management of clinical formulations: determination of expiration date of powdered medicine prepared by grinding tablets].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20080601

Title: Antithrombin inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production by monocytes in vitro through inhibition of Egr-1 expression.

Journal: Journal of thrombosis and haemostasis : JTH 20080301

Title: Molecular mechanisms of the antiproliferative effect of beraprost, a prostacyclin agonist, in murine vascular smooth muscle cells.

Journal: Journal of cellular physiology 20080201

Title: Effect of long-term administration of a prostacyclin analogue (beraprost sodium) on myocardial fibrosis in Dahl rats.

Journal: The Journal of veterinary medical science 20071201

Title: Determination of beraprost in human plasma by a high-performance liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071115

Title: Pilot study of short-term effects of a novel long-acting oral beraprost in patients with pulmonary arterial hypertension.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20071101

Title: Effects of combined therapy with a Rho-kinase inhibitor and prostacyclin on monocrotaline-induced pulmonary hypertension in rats.

Journal: Journal of cardiovascular pharmacology 20070801

Title: Inducible cAMP early repressor inhibits growth of vascular smooth muscle cell.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20070701

Title: Prostaglandins PGE(2) and PGI(2) promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation.

Journal: Experimental cell research 20070701

Title: Involvement of inducible nitric oxide synthase in blood flow decrease in vein induced by hen-egg white lysozyme.

Journal: Biological & pharmaceutical bulletin 20070701

Title: The value of approved therapies for pulmonary arterial hypertension.

Journal: American heart journal 20070601

Title: Beneficial effect of beraprost sodium plus telmisartan in the prevention of arterial stiffness development in elderly patients with hypertension and cerebral infarction.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20070601

Title: [Disorders of pulmonary circulation].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20070528

Title: The effect of prostacyclin agonists on the differentiation of phorbol ester treated human erythroleukemia cells.

Journal: Prostaglandins & other lipid mediators 20070501

Title: Combination therapy with oral sildenafil and beraprost for pulmonary arterial hypertension associated with CREST syndrome.

Journal: International heart journal 20070501

Title: Prostanoid therapy for pulmonary arterial hypertension.

Journal: Clinics in chest medicine 20070301

Title: Combination therapy and new types of agents for pulmonary arterial hypertension.

Journal: Clinics in chest medicine 20070301

Title: Prostaglandin I(2) and E(2) mediate the protective effects of cyclooxygenase-2 in a mouse model of immune-mediated liver injury.

Journal: Hepatology (Baltimore, Md.) 20070101

Title: Marked improvement with sildenafil in a patient with idiopathic pulmonary arterial hypertension unresponsive to beraprost and sarpogrelate.

Journal: Internal medicine (Tokyo, Japan) 20070101

Title: Effect of hypoxia and Beraprost sodium on human pulmonary arterial smooth muscle cell proliferation: the role of p27kip1.

Journal: Respiratory research 20070101

Title: Prostacyclin antagonism reduces pain and inflammation in rodent models of hyperalgesia and chronic arthritis.

Journal: The Journal of pharmacology and experimental therapeutics 20061201

Title: Beraprost sodium enhances neovascularization in ischemic myocardium by mobilizing bone marrow cells in rats.

Journal: Biochemical and biophysical research communications 20061103

Title: [Unexplained pulmonary arterial hypertension in a patient with lung resection, treated with sildenafil and beraprost].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20061101

Title: Improvement of walking disturbance by beraprost sodium in rat femoral artery occlusion models.

Journal: European journal of pharmacology 20060918

Title: The prostacyclin analog beraprost sodium augments the efficacy of therapeutic angiogenesis induced by autologous bone marrow cells.

Journal: Annals of vascular surgery 20060901

Title: Current treatment options in children with pulmonary arterial hypertension and experiences with oral bosentan.

Journal: European journal of clinical investigation 20060901

Title: Regulation of iodothyronine deiodinase and roles of thyroid hormones in human coronary artery smooth muscle cells.

Journal: Atherosclerosis 20060501

Title: Competitive binding of CREB and ATF2 to cAMP/ATF responsive element regulates eNOS gene expression in endothelial cells.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20060501

Title: Protective effect of cyclic AMP against cisplatin-induced nephrotoxicity.

Journal: Free radical biology & medicine 20060501

Title: Effect of YM-254890, a specific Galphaq/11 inhibitor, on experimental peripheral arterial disease in rats.

Journal: European journal of pharmacology 20060424

Title: Effects of oral beraprost sodium, a prostaglandin I2 analogue, on endothelium dependent vasodilatation in the forearm of patients with coronary artery disease.

Journal: Clinical and experimental pharmacology & physiology 20060401

Title: Beraprost sodium-induced hypotension in two patients after cardiac surgery.

Journal: International heart journal 20060301

Title: Perfusion lung scan as a prognostic indicator of response to beraprost sodium in idiopathic pulmonary arterial hypertension.

Journal: Pulmonary pharmacology & therapeutics 20060101

Title: Mid-term efficacy of beraprost, an oral prostacyclin analog, in the treatment of distal CTEPH: a case control study.

Journal: Cardiology 20060101

Title: New therapeutic agents for pulmonary vascular disease.

Journal: Paediatric respiratory reviews 20051201

Title: The prostacyclin analogue beraprost sodium prevents occlusion of bypass grafts in patients with lower extremity arterial occlusive disease: a 20-year retrospective study.

Journal: Annals of vascular surgery 20051101

Title: Combination therapy of prostacyclin for pulmonary hypertension in congenital heart disease.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20051101

Title: Beraprost sodium, a prostacyclin (PGI) analogue, ameliorates concanavalin A-induced liver injury in mice.

Journal: Liver international : official journal of the International Association for the Study of the Liver 20051001

Title: Vascular endothelium as a target of beraprost sodium and fenofibrate for antiatherosclerotic therapy in type 2 diabetes mellitus.

Journal: Vascular health and risk management 20050901

Title: Human follicular dendritic cells express prostacyclin synthase: a novel mechanism to control T cell numbers in the germinal center.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20050801

Title: Bosentan improves exercise tolerance and Tei index in patients with pulmonary hypertension and prostanoid therapy.

Journal: Chest 20050801

Title: Prostacyclin therapy for pulmonary arterial hypertension: new directions.

Journal: Seminars in respiratory and critical care medicine 20050801

Title: Comparative effect of antiplatelet therapy in retinal vein occlusion evaluated by the particle-counting method using light scattering.

Journal: American journal of ophthalmology 20050701

Title: [Pulmonary hypertension in hereditary haemorrhagic teleangiectasia (Rendu-Osler-Weber disease). Progression over 10 years].

Journal: Deutsche medizinische Wochenschrift (1946) 20050610

Title: A prostacyclin analog prevents radiocontrast nephropathy via phosphorylation of cyclic AMP response element binding protein.

Journal: The American journal of pathology 20050501

Title: Addition of oral sildenafil to beraprost is a safe and effective therapeutic option for patients with pulmonary hypertension.

Journal: Journal of cardiovascular pharmacology 20050401

Title: Clinical and experimental evidence for prevention of acute renal failure induced by radiographic contrast media.

Journal: Journal of pharmacological sciences 20050401

Title: Prostacyclin does not inhibit rho-kinase: an implication for the treatment of pulmonary hypertension.

Journal: Journal of cardiovascular pharmacology 20050201

Title: Comparison of the acute pulmonary vasodilating effect of beraprost sodium and nitric oxide in congenital heart disease.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20050101

Title: PGE1 and other prostaglandins in the treatment of intermittent claudication: a meta-analysis.

Journal: Angiology 20050101

Title: Beraprost therapy in children with pulmonary hypertension secondary to congenital heart disease.

Journal: Pediatric cardiology 20050101

Title: Comparative effect of antiplatelet therapy in retinal vein occlusion evaluated by the particle-counting method using light scattering.

Journal: American journal of ophthalmology 20041101

Title: Prostacyclin analogue (beraprost) relief of cold intolerance after digital replantation and revascularization.

Journal: Journal of hand surgery (Edinburgh, Scotland) 20040801

Title: A stable prostacyclin analogue reduces high serum TNF-alpha levels in diabetic patients.

Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20040701

Title: The prostacyclin analogue beraprost sodium prevents development of arterial stiffness in elderly patients with cerebral infarction.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20040601

Title: Studies on the effectiveness and safety of cilostazol, beraprost sodium, prostaglandin E1 for the treatment of intermittent claudication.

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20040601

Title: A prostacyclin analog beraprost sodium attenuates radiocontrast media-induced LLC-PK1 cells injury.

Journal: Kidney international 20040501

Title: [Effect of long-term therapy with oral Beraprost on survival of patients with arterial and inoperable thromboembolic pulmonary hypertension].

Journal: Polskie Archiwum Medycyny Wewnetrznej 20040401

Title: Identical twins with primary pulmonary hypertension: beraprost vs epoprostenol.

Journal: Chest 20040301

Title: [Treatment of pulmonary arterial hypertension associated to systemic sclerosis].

Journal: La Revue de medecine interne 20040301

Title: [Effects of acute administration of beraprost sodium on parameters related to atherosclerotic vascular damage in coronary artery disease].

Journal: Journal of cardiology 20040201

Title: [Primary pulmonary hypertension: prospects for treatment].

Journal: Medicina clinica 20040124

Title: A combination of oral sildenafil and beraprost ameliorates pulmonary hypertension in rats.

Journal: American journal of respiratory and critical care medicine 20040101

Title: Mild irritant prevents ethanol-induced gastric mucosal microcirculatory disturbances through actions of calcitonin gene-related peptide and PGI2 in rats.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20040101

Title: Advancing therapy for pulmonary arterial hypertension: can animal models help?

Journal: American journal of respiratory and critical care medicine 20040101

Title: Effect of beraprost sodium on pulmonary vascular resistance in candidates for a Fontan procedure: a preliminary study.

Journal: Pediatrics international : official journal of the Japan Pediatric Society 20031201

Title: A convenient synthesis of the beraprost intermediate: a useful method for introducing a C3 unit at the benzyl position.

Journal: Organic letters 20031002

Title: Transcriptional stimulation of the eNOS gene by the stable prostacyclin analogue beraprost is mediated through cAMP-responsive element in vascular endothelial cells: close link between PGI2 signal and NO pathways.

Journal: Circulation research 20030919

Title: Bosentan treatment in patients with primary pulmonary hypertension receiving nonparenteral prostanoids.

Journal: The European respiratory journal 20030801

Title: Low-dose systemic phosphodiesterase III inhibitor pimobendan combined with prostacyclin therapy in a patient with severe primary pulmonary hypertension.

Journal: Cardiovascular drugs and therapy 20030701

Title: Beraprost therapy for pulmonary arterial hypertension.

Journal: Journal of the American College of Cardiology 20030618

Title: Emerging therapies for pulmonary hypertension: striving for efficacy and safety.

Journal: Journal of the American College of Cardiology 20030618

Title: Role of prostaglandin I2 in the gene expression induced by mechanical stress in spinal ligament cells derived from patients with ossification of the posterior longitudinal ligament.

Journal: The Journal of pharmacology and experimental therapeutics 20030601

Title: Clinical value of prostacyclin and its analogs in the management of pulmonary arterial hypertension.

Journal: Current vascular pharmacology 20030601

Title: Treatment of intermittent claudication with beraprost sodium, an orally active prostaglandin I2 analogue: a double-blinded, randomized, controlled trial.

Journal: Journal of the American College of Cardiology 20030521

Title: Beraprost for the treatment of intermittent claudication.

Journal: Journal of the American College of Cardiology 20030521

Title: Hemodynamic and hormonal effects of beraprost sodium, an orally active prostacyclin analogue, in patients with secondary precapillary pulmonary hypertension.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20030501

Title: Effect of orally active prostacyclin analogue on survival in patients with chronic thromboembolic pulmonary hypertension without major vessel obstruction.

Journal: Chest 20030501

Title: Effect of single-drug treatment on idiopathic sudden sensorineural hearing loss.

Journal: Auris, nasus, larynx 20030501

Title: Effects of H2O2 on membrane potential of smooth muscle cells in rabbit mesenteric resistance artery.

Journal: European journal of pharmacology 20030319

Title: Effects of the prostaglandin I2 analogue, beraprost sodium, on vascular cell adhesion molecule-1 expression in human vascular endothelial cells and circulating vascular cell adhesion molecule-1 level in patients with type 2 diabetes mellitus.

Journal: Metabolism: clinical and experimental 20030201

Title: [Combination of oral endothelin-A receptor antagonist and oral prostacyclin analogue is superior to each drug alone in ameliorating pulmonary hypertension in rats].

Journal: Journal of cardiology 20030101

Title: Modulation of tumor-selective vascular blood flow and extravasation by the stable prostaglandin 12 analogue beraprost sodium.

Journal: Journal of drug targeting 20030101

Title: [Role of prostacyclin and its derivatives in the treatment of pulmonary arterial hypertension].

Journal: Medicina 20030101

Title: Effect of long-term administration of prostaglandin I(2) in incipient diabetic nephropathy.

Journal: Nephron 20021201

Title: Reduced function of endothelial prostacyclin in human omental resistance arteries in pre-eclampsia.

Journal: The Journal of physiology 20021115

Title: Beraprost sodium for pulmonary hypertension with congenital heart disease.

Journal: Pediatrics international : official journal of the Japan Pediatric Society 20021001

Title: Impaired endothelial dysfunction in diabetes mellitus rats was restored by oral administration of prostaglandin I2 analogue.

Journal: The Journal of endocrinology 20021001

Title: The new clinical trials on pharmacological treatment in pulmonary arterial hypertension.

Journal: The European respiratory journal 20021001

Title: Beraprost sodium, prostacyclin analogue, attenuates glomerular hyperfiltration and glomerular macrophage infiltration by modulating ecNOS expression in diabetic rats.

Journal: Diabetes research and clinical practice 20020901

Title: Current and emerging therapy for primary pulmonary hypertension.

Journal: The Annals of pharmacotherapy 20020901

Title: Beraprost sodium, a prostaglandin I2 analogue, protects against advanced gycation end products-induced injury in cultured retinal pericytes.

Journal: Molecular medicine (Cambridge, Mass.) 20020901

Title: Amelioration by beraprost sodium, a prostacyclin analogue, of established renal dysfunction in rat glomerulonephritis model.

Journal: European journal of pharmacology 20020802

Title: Small aggregates of platelets can be detected sensitively by a flow cytometer equipped with an imaging device: mechanisms of epinephrine-induced aggregation and antiplatelet effects of beraprost.

Journal: Cytometry 20020801

Title: A combination of oral endothelin-A receptor antagonist and oral prostacyclin analogue is superior to each drug alone in ameliorating pulmonary hypertension in rats.

Journal: Journal of the American College of Cardiology 20020703

Title: Long-term administration of beraprost, an oral prostacyclin analogue, improves pulmonary diffusion capacity in patients with systemic sclerosis.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20020701

Title: Prosthetic grafts for above-knee femoropopliteal bypass. A multicenter retrospective study of 564 grafts.

Journal: International angiology : a journal of the International Union of Angiology 20020601

Title: Effects of beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled trial.

Journal: Journal of the American College of Cardiology 20020501

Title: Oral beraprost sodium improves exercise capacity and ventilatory efficiency in patients with primary or thromboembolic pulmonary hypertension.

Journal: Heart (British Cardiac Society) 20020401

Title: [Therapeutic management of primary pulmonary hypertension].

Journal: Presse medicale (Paris, France : 1983) 20020223

Title: Cyclic AMP inhibits stretch-induced overexpression of fibronectin in glomerular mesangial cells.

Journal: European journal of pharmacology 20020222

Title: Differential effects of stable prostacyclin analogs on smooth muscle proliferation and cyclic AMP generation in human pulmonary artery.

Journal: American journal of respiratory cell and molecular biology 20020201

Title: Beraprost: a review of its pharmacology and therapeutic efficacy in the treatment of peripheral arterial disease and pulmonary arterial hypertension.

Journal: Drugs 20020101

Title: Effects of beraprost sodium (Dorner) in patients with diabetes mellitus complicated by chronic arterial obstruction.

Journal: Angiology 20020101

Title: Comparison of the responses to thrombin in monkey renal and uterine arteries.

Journal: Journal of the Society for Gynecologic Investigation 20020101

Title: Emerging medical therapies for pulmonary arterial hypertension.

Journal: Progress in cardiovascular diseases 20020101

Title: Long term treatment of pulmonary arterial hypertension with beraprost, an oral prostacyclin analogue.

Journal: Heart (British Cardiac Society) 20011201

Title: Beraprost sodium regulates cell cycle in vascular smooth muscle cells through cAMP signaling by preventing down-regulation of p27(Kip1).

Journal: Cardiovascular research 20011201

Title: MaxiK channel-mediated relaxation of guinea-pig aorta following stimulation of IP receptor with beraprost via cyclic AMP-dependent and -independent mechanisms.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20011201

Title: [Effects of long-term treatment with prostacyclin on plasma adrenomedullin in patients with primary pulmonary hypertension].

Journal: Journal of cardiology 20011101

Title: PGl2 analogue mitigates the progression rate of renal dysfunction improving renal blood flow without glomerular hyperfiltration in patients with chronic renal insufficiency.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20011001

Title: Medical therapy of pulmonary hypertension. The prostacyclins.

Journal: Clinics in chest medicine 20010901

Title: New and experimental therapies for pulmonary hypertension.

Journal: Clinics in chest medicine 20010901

Title: Effects of beraprost sodium on canine cauda equina function and blood flow using a chronic spinal cord compression model.

Journal: Journal of spinal disorders 20010801

Title: Increased islet viability by addition of beraprost sodium to collagenase solution.

Journal: Pancreas 20010701

Title: Enhanced neutrophil superoxide anion production and its modification by beraprost sodium in spontaneously hypertensive rats.

Journal: American journal of hypertension 20010701

Title: [Oral administration of beraprost sodium did not exacerbate pulmonary hypertension with CREST syndrome].

Journal: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20010510

Title: Changes in skin blood flow in type 2 diabetes induced by prostacyclin: association with ankle brachial index and plasma thrombomodulin levels.

Journal: Metabolism: clinical and experimental 20010501

Title: Mechanisms of relaxation induced by angiotensin II in isolated canine and human uterine arteries.

Journal: Journal of cardiovascular pharmacology 20010501

Title: Effects of inhaled prostacyclin analogue on chronic hypoxic pulmonary hypertension.

Journal: Journal of cardiovascular pharmacology 20010301

Title: Comparative effects of beraprost, a stable analogue of prostacyclin, with PGE(1), nitroglycerin and nifedipine on canine model of vasoconstrictive pulmonary hypertension.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20010301

Title: [Pharmacological and clinical properties of beraprost sodium, orally active prostacyclin analogue].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20010201

Title: Prostacyclin analog prevents stress-induced expression of immediate early genes and gastric mucosal lesions in the rat stomach.

Journal: Life sciences 19990101

Title: A dose-effect study of beraprost sodium in intermittent claudication.

Journal: Journal of cardiovascular pharmacology 19960601

Title: Clinical evaluation on combined administration of oral prostacyclin analogue beraprost and phosphodiesterase inhibitor cilostazol.

Journal: Pharmacological research 19950201

Title: Effect of beraprost sodium, a stable prostacyclin analogue, on pulmonary thromboembolism in mice.

Journal: Thrombosis research 19950115

Title: Pharmacokinetics and platelet antiaggregating effects of beraprost, an oral stable prostacyclin analogue, in healthy volunteers.

Journal: Journal of cardiovascular pharmacology 19931101

Title: Protective effect of beraprost sodium, a new chemically stable prostacyclin analogue, against the deterioration of baroreceptor reflex following transient global cerebral ischaemia in dogs.

Journal: British journal of pharmacology 19900101

Title: Specific binding of the new stable epoprostenol analogue beraprost sodium to prostacyclin receptors on human and rat platelets.

Journal: Arzneimittel-Forschung 19890401

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