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886-38-4,MFCD00001311
Catalog No.:AA003PMQ

886-38-4 | Diphenylcyclopropenone

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250mg
98%
in stock  
$9.00   $7.00
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1g
98%
in stock  
$21.00   $15.00
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5g
98%
in stock  
$80.00   $56.00
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25g
95%
in stock  
$363.00   $254.00
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100g
95%
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$1,407.00   $985.00
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003PMQ
Chemical Name:
Diphenylcyclopropenone
CAS Number:
886-38-4
Molecular Formula:
C15H10O
Molecular Weight:
206.2393
MDL Number:
MFCD00001311
SMILES:
O=C1C(=C1c1ccccc1)c1ccccc1
NSC Number:
57541
Properties
Properties
 
BP:
305.09°C (rough estimate)  
Form:
Solid  
MP:
118-122 °C(lit.)  
Refractive Index:
1.6324 (estimate)  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
284  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
3.3  

Literature

Title: SENS-IS, a 3D reconstituted epidermis based model for quantifying chemical sensitization potency: Reproducibility and predictivity results from an inter-laboratory study.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20160401

Title: Human relevance of an in vitro gene signature in HaCaT for skin sensitization.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20150201

Title: Systemic immunogenicity of para-Phenylenediamine and Diphenylcyclopropenone: two potent contact allergy-inducing haptens.

Journal: Immunologic research 20140101

Title: High altitude impairs in vivo immunity in humans.

Journal: High altitude medicine & biology 20130601

Title: Allergic contact dermatitis induces upregulation of identical microRNAs in humans and mice.

Journal: Contact dermatitis 20121101

Title: Solute-solvent hydrogen-bonding in room temperature ionic liquids studied by Raman spectroscopy.

Journal: Physical chemistry chemical physics : PCCP 20121021

Title: The safety and efficacy of diphencyprone for the treatment of alopecia areata in children.

Journal: Archives of dermatology 20120901

Title: The contact sensitizer diphenylcyclopropenone has adjuvant properties in mice and potential application in epicutaneous immunotherapy.

Journal: Allergy 20120501

Title: Topical immunotherapy with diphenylcyclopropenone of patients with alopecia areata--a large retrospective study on 142 patients with a self-controlled design.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20120401

Title: Narrow-band ultraviolet B treatment for diphenylcyclopropenone-induced vitiliginous lesions.

Journal: Acta dermato-venereologica 20120101

Title: Recall dermatitis at patch test sites in alopecia areata treated with diphencyprone.

Journal: Dermatitis : contact, atopic, occupational, drug 20120101

Title: Topical diphencyprone immunotherapy for a large primary melanoma on an elderly leg.

Journal: American journal of clinical dermatology 20111201

Title: Impaired hapten sensitization in patients with autoimmune disease.

Journal: Clinical and experimental immunology 20110901

Title: Dramatic regression of cutaneous, nodal, and visceral melanoma metastases.

Journal: Journal of the American Academy of Dermatology 20110901

Title: Exercise-induced stress inhibits both the induction and elicitation phases of in vivo T-cell-mediated immune responses in humans.

Journal: Brain, behavior, and immunity 20110801

Title: Diphencyprone and topical tacrolimus as two topical immunotherapeutic modalities. Are they effective in the treatment of alopecia areata among Egyptian patients? A study using CD4, CD8 and MHC II as markers.

Journal: The Journal of dermatological treatment 20110201

Title: Videocapillaroscopic pattern of alopecia areata before and after diphenylciclopropenone treatment.

Journal: International journal of immunopathology and pharmacology 20110101

Title: Changes of cell-surface thiols and intracellular signaling in human monocytic cell line THP-1 treated with diphenylcyclopropenone.

Journal: The Journal of toxicological sciences 20101201

Title: UV-induced tolerance to a contact allergen is impaired in polymorphic light eruption.

Journal: The Journal of investigative dermatology 20101101

Title: Phototherapy as a useful therapeutic option in the treatment of diphenylcyclopropenone-induced vitiligo.

Journal: Acta dermato-venereologica 20101101

Title: TH17 is involved in the remarkable regression of metastatic malignant melanoma to topical diphencyprone.

Journal: Journal of drugs in dermatology : JDD 20101101

Title: Pigmented contact dermatitis due to therapeutic sensitizer as complication of contact immunotherapy in alopecia areata.

Journal: The Journal of dermatology 20101001

Title: Effects of diphencyprone on expression of Bcl-2 protein in patients with alopecia areata.

Journal: Immunopharmacology and immunotoxicology 20100901

Title: A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells.

Journal: Cutaneous and ocular toxicology 20100901

Title: Effect of taxifolin glycoside on atopic dermatitis-like skin lesions in NC/Nga mice.

Journal: Phytotherapy research : PTR 20100701

Title: Susceptibility and reactivity in polysensitized individuals following controlled induction.

Journal: Contact dermatitis 20100701

Title: Five-year experience in the treatment of alopecia areata with DPC.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20100301

Title: Alopecia areata update: part II. Treatment.

Journal: Journal of the American Academy of Dermatology 20100201

Title: Cytokines and other mediators in alopecia areata.

Journal: Mediators of inflammation 20100101

Title: Topical diphencyprone immunotherapy for cutaneous metastatic melanoma.

Journal: The Australasian journal of dermatology 20091101

Title: Immunotherapy for childhood warts.

Journal: Pediatric annals 20090701

Title: Treatment of alopecia areata in children.

Journal: Pediatric annals 20090701

Title: Fexofenadine hydrochloride enhances the efficacy of contact immunotherapy for extensive alopecia areata: Retrospective analysis of 121 cases.

Journal: The Journal of dermatology 20090601

Title: Vitiligo as an adverse reaction to topical diphencyprone.

Journal: Annals of the Academy of Medicine, Singapore 20090301

Title: Alopecia areata: topical immunotherapy treatment with diphencyprone.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20080301

Title: Evaluation of delayed-type hypersensitivity in patients with suspected immunodeficiency.

Journal: The American journal of medicine 20080301

Title: Comparative study on the sustained efficacy of diphencyprone immunotherapy versus cryotherapy in viral warts.

Journal: Pediatric dermatology 20080101

Title: Topical immunotherapy with diphenylcyclopropenone in vitiligo: a preliminary experience.

Journal: Indian journal of dermatology, venereology and leprology 20080101

Title: Prospective study of urticaria after diphencyprone therapy in patients with viral warts.

Journal: International journal of dermatology 20071201

Title: Elicitation of contact hypersensitivity after repeated suberythemal exposures of humans to solar simulated radiation: number of epidermal Langerhans cells.

Journal: Contact dermatitis 20071001

Title: Changes in distribution pattern of CD8 lymphocytes in the scalp in alopecia areata during treatment with diphencyprone.

Journal: Archives of dermatological research 20070801

Title: Treatment of extensive cutaneous metastatic melanoma with topical diphencyprone.

Journal: Journal of the American Academy of Dermatology 20070501

Title: Generalized urticaria with use of diphencyprone in the treatment of warts.

Journal: Journal of drugs in dermatology : JDD 20070501

Title: Topical immunotherapy with diphenylcyclopropenone in the treatment of chronic extensive alopecia areata.

Journal: Clinical and experimental dermatology 20070101

Title: Diphenylcyclopropenone immunotherapy in ophiasis.

Journal: Indian journal of dermatology, venereology and leprology 20070101

Title: Neuronal conditions of spinal cord in dermatitis are improved by olopatadine.

Journal: European journal of pharmacology 20061010

Title: Topical diphenylcyclopropenone as a measure of immune competence in HIV-seropositive subjects.

Journal: Journal of drugs in dermatology : JDD 20061001

Title: Treatment of palmoplantar warts with a diphencyprone and salicylic acid ointment.

Journal: The Australasian journal of dermatology 20060801

Title: No adaptation to UV-induced immunosuppression and DNA damage following exposure of mice to chronic UV-exposure.

Journal: Journal of photochemistry and photobiology. B, Biology 20060703

Title: Treatment of disseminated facial warts through contact immunotherapy with diphenylcyclopropenone (DPCP).

Journal: Dermatology online journal 20060227

Title: Fexofenadine, an H1-receptor antagonist, partially but rapidly inhibits the itch of contact dermatitis induced by diphenylcyclopropenone in patients with alopecia areata.

Journal: The Journal of dermatology 20060201

Title: Diphenylcyclopropenone treatment of alopecia areata induces apoptosis of perifollicular lymphocytes.

Journal: European journal of dermatology : EJD 20060101

Title: Alteration of sensorineural circuits in spinal cord by chronic contact dermatitis.

Journal: Somatosensory & motor research 20050901

Title: Suppression of contact hypersensitivity after repeated exposures of humans to low doses of solar simulated radiation.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20050701

Title: Topical immunotherapy with diphencyprone in the treatment of extensive and/or long-lasting alopecia areata.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20050501

Title: Urticaria as a side-effect of diphencyprone therapy for resistant viral warts.

Journal: The British journal of dermatology 20050301

Title: Topical immunotherapy of severe alopecia areata with diphenylcyclopropenone (DPCP): experience in an Iranian population.

Journal: BMC dermatology 20050101

Title: Topical immunotherapy with diphenylcyclopropenone in combination with DTIC and radiation for cutaneous metastases of melanoma.

Journal: Dermatology (Basel, Switzerland) 20050101

Title: Treatment of molluscum contagiosum with topical diphencyprone therapy.

Journal: Acta dermato-venereologica 20050101

Title: Histological examination in assessment of ultraviolet-induced suppression of contact hypersensitivity response.

Journal: Polish journal of pathology : official journal of the Polish Society of Pathologists 20050101

Title: Allergic contact dermatitis from dyes in wigs following diphencyprone treatment.

Journal: Contact dermatitis 20040901

Title: Topical sensitizers in alopecia areata.

Journal: Dermatology nursing 20040801

Title: The progressive state, in contrast to the stable or regressive state of alopecia areata, is reflected in peripheral blood mononuclear cells.

Journal: Experimental dermatology 20040701

Title: Expression of vascular endothelial growth factor, apoptosis inhibitors (survivin and p16) and CCL27 in alopecia areata before and after diphencyprone treatment: an immunohistochemical study.

Journal: The British journal of dermatology 20040501

Title: Ultraviolet radiation causes less immunosuppression in patients with polymorphic light eruption than in controls.

Journal: The Journal of investigative dermatology 20040201

Title: Bald spots on a young girl.

Journal: The Journal of family practice 20040101

Title: Restoration of hair growth with topical diphencyprone in mouse and rat models of alopecia areata.

Journal: Journal of the American Academy of Dermatology 20031201

Title: Diphenylcyclopropenone (diphencyprone, DPCP) in the treatment of chronic severe alopecia areata (AA).

Journal: European annals of allergy and clinical immunology 20031201

Title: [Topical immunomodulators in dermatology].

Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20030701

Title: The anomalous solvent effect in the vibrational spectrum of 2,3-diphenyl-cycloprop-2-enone: an experimental and theoretical investigation.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20021201

Title: Urticaria after topical immunotherapy with diphenylcyclopropenone.

Journal: Contact dermatitis 20021101

Title: Langerhans cells that express matrix metalloproteinase 9 increase in human dermis during sensitization to diphenylcyclopropenone in patients with alopecia areata.

Journal: The British journal of dermatology 20020801

Title: An interesting response to diphencyprone (DPC) sensitization on facial warts: review of DPC treatment for viral warts.

Journal: The Journal of dermatological treatment 20020601

Title: [Alopecia areata].

Journal: Therapeutische Umschau. Revue therapeutique 20020501

Title: Diphencyprone for the treatment of alopecia areata: more data and new aspects.

Journal: Archives of dermatology 20020101

Title: The use of diphenylcyclopropenone in the treatment of recalcitrant warts.

Journal: Journal of cutaneous medicine and surgery 20020101

Title: Diphencyprone immunotherapy alters anti-hair follicle antibody status in patients with alopecia areata.

Journal: European journal of dermatology : EJD 20020101

Title: Topical immunotherapy: unapproved uses, dosages, or indications.

Journal: Clinics in dermatology 20020101

Title: The therapeutic use of topical contact sensitizers in benign dermatoses.

Journal: The British journal of dermatology 20010901

Title: Impaired responses of peripheral blood mononuclear cells to T-cell stimulants in alopecia areata patients with a poor response to topical immunotherapy.

Journal: The British journal of dermatology 20010901

Title: Predictive model for immunotherapy of alopecia areata with diphencyprone.

Journal: Archives of dermatology 20010801

Title: Contact sensitization pretransplantation predicts acute hepatic allograft rejection.

Journal: Hepatology (Baltimore, Md.) 20010501

Title: Exogenous topical lactoferrin inhibits allergen-induced Langerhans cell migration and cutaneous inflammation in humans.

Journal: The British journal of dermatology 20010401

Title: The use of topical diphenylcyclopropenone for the treatment of extensive alopecia areata.

Journal: Journal of the American Academy of Dermatology 20010101

Title: Expert witnesses and experimental treatment: the extent of the duty to warn of risks when using experimental treatment.

Journal: The Medico-legal journal 20010101

Title: [Treatment of alopecia areata with diphencyprone].

Journal: Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20010101

Title: Activation of murine epidermal TCR-gamma delta+ T cells by keratinocytes treated with contact sensitizers.

Journal: Journal of immunology (Baltimore, Md. : 1950) 19950915

Title: Yugang Gong, et al. Diphenylcyclopropenone plays an effective therapeutic role by up-regulating the TSLP/OX40L/IL-13 pathway in severe alopecia areata. Exp Dermatol. 2021 Feb;30(2):278-283.

Title: Zekayi Kutlubay, et al. Assessment of treatment efficacy of diphenylcyclopropenone (DPCP) for alopecia areata. Turk J Med Sci. 2020 Dec 17;50(8):1817-1824.

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