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890405-51-3,MFCD30187363
Catalog No.:AA01EMXK

890405-51-3 | 3BDO

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$49.00   $34.00
- +
5mg
98%
in stock  
$125.00   $88.00
- +
10mg
98%
in stock  
$173.00   $121.00
- +
25mg
98%
in stock  
$294.00   $206.00
- +
100mg
98%
in stock  
$950.00   $665.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01EMXK
Chemical Name:
3BDO
CAS Number:
890405-51-3
Molecular Formula:
C18H17NO5
Molecular Weight:
327.3313
MDL Number:
MFCD30187363
SMILES:
O=C1OC(CC1Cc1ccccc1)COc1ccccc1[N+](=O)[O-]
Properties
Computed Properties
 
Complexity:
443  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
5  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
2  
XLogP3:
3.7  

Literature

Title: Metformin alleviated endotoxemia-induced acute lung injury via restoring AMPK-dependent suppression of mTOR.

Journal: Chemico-biological interactions 20180801

Title: A butyrolactone derivative suppressed lipopolysaccharide-induced autophagic injury through inhibiting the autoregulatory loop of p8 and p53 in vascular endothelial cells.

Journal: The international journal of biochemistry & cell biology 20120201

Title: Butyrolactone derivative 3-benzyl-5-((2-nitrophenoxy) methyl)-dihydrofuran-2(3H)-one protects against amyloid-β peptides-induced cytotoxicity in PC12 cells.

Journal: Journal of Alzheimer's disease : JAD 20120101

Title: A butyrolactone derivative 3BDO alleviates memory deficits and reduces amyloid-β deposition in an AβPP/PS1 transgenic mouse model.

Journal: Journal of Alzheimer's disease : JAD 20120101

Title: Protective effects of a synthesized butyrolactone derivative against chloroquine-induced autophagic vesicle accumulation and the disturbance of mitochondrial membrane potential and Na+,K+-ATPase activity in vascular endothelial cells.

Journal: Chemical research in toxicology 20090316

Title: A novel butyrolactone derivative inhibited smooth muscle cell migration and proliferation and maintained endothelial cell functions through selectively affecting Na, K-ATPase activity and mitochondria membrane potential during in vitro angiogenesis.

Journal: Journal of cellular biochemistry 20080815

Title: A novel butyrolactone derivative inhibited apoptosis and depressed integrin beta4 expression in vascular endothelial cells.

Journal: Bioorganic & medicinal chemistry letters 20070115

Title: Ge D, et al. Identification of a novel MTOR activator and discovery of a competing endogenous RNA regulating autophagy in vascular endothelial cells. Autophagy. 2014 Jun;10(6):957-71.

Title: Peng N, et al. An activator of mTOR inhibits oxLDL-induced autophagy and apoptosis in vascular endothelial cells and restricts atherosclerosis in apolipoprotein E-/- mice. Sci Rep. 2014 Jul 1;4:5519.

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