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89226-75-5,MFCD00896434
Catalog No.:AA0043DQ

89226-75-5 | Manidipine DiHCl

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100mg
95%
in stock  
$18.00   $13.00
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1g
95%
in stock  
$58.00   $40.00
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5g
95%
in stock  
$212.00   $148.00
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25g
99%
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$720.00   $504.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0043DQ
Chemical Name:
Manidipine DiHCl
CAS Number:
89226-75-5
Molecular Formula:
C35H38Cl2N4O6
Molecular Weight:
683.6213
MDL Number:
MFCD00896434
SMILES:
COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN1CCN(CC1)C(c1ccccc1)c1ccccc1)C.[Cl-].[Cl-].[H+].[H+]
Properties
Properties
 
BP:
722 °C at 760 mmHg  
Form:
Solid  
MP:
209 - 211°C  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
1090  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
47  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
11  
Undefined Atom Stereocenter Count:
1  

Literature

Title: Effects of manidipine and delapril in hypertensive patients with type 2 diabetes mellitus: the delapril and manidipine for nephroprotection in diabetes (DEMAND) randomized clinical trial.

Journal: Hypertension (Dallas, Tex. : 1979) 20111101

Title: Optimal treatment strategies for patients with hypertension and diabetes: are effects on metabolism important?

Journal: Hypertension (Dallas, Tex. : 1979) 20111101

Title: Efficacy and safety profiles of manidipine compared with amlodipine: a meta-analysis of head-to-head trials.

Journal: Blood pressure 20110201

Title: Effects of manidipine and its combination with an ACE inhibitor on insulin sensitivity and metabolic, inflammatory and prothrombotic markers in hypertensive patients with metabolic syndrome: the MARCADOR study.

Journal: Clinical drug investigation 20110101

Title: Vascular and metabolic properties of manidipine.

Journal: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20110101

Title: Manidipine for hypertension not controlled by dual therapy in patients with diabetes mellitus: a non-comparative, open-label study.

Journal: Clinical drug investigation 20110101

Title: Combination delapril/manidipine as antihypertensive therapy in high-risk patients.

Journal: Clinical drug investigation 20110101

Title: Delapril and manidipine measurements by liquid chromatography-tandem mass spectrometry in a pharmaceutical formulation.

Journal: European journal of mass spectrometry (Chichester, England) 20110101

Title: Clinical case: Peritoneal dialysis patient with cloudy peritoneal fluid following administration of calcium antagonists.

Journal: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20110101

Title: Manidipine reduces pro-inflammatory cytokines secretion in human endothelial cells and macrophages.

Journal: Pharmacological research 20100901

Title: Manidipine treatment in patients with albuminuria not sufficiently reduced with renin-angiotensin system blockers.

Journal: Expert review of cardiovascular therapy 20100601

Title: Indigotine, azorubine, and cochineal red as photoprotectors of manidipine.

Journal: Drug development and industrial pharmacy 20100301

Title: Manidipine in hypertensive patients with metabolic syndrome: the MARIMBA study.

Journal: Expert review of cardiovascular therapy 20090701

Title: Fixed-dose manidipine/delapril versus losartan/hydrochlorothiazide in hypertensive patients with type 2 diabetes and microalbuminuria.

Journal: Advances in therapy 20090301

Title: Metabolic effects of manidipine.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20090101

Title: [Cardio-metabolic properties of manidipine: beyond lowering arterial pressure?].

Journal: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20090101

Title: Add-on manidipine versus amlodipine in diabetic patients with hypertension and microalbuminuria: the AMANDHA study.

Journal: Expert review of cardiovascular therapy 20081101

Title: Combined simvastatin-manidipine protect against ischemia-reperfusion injury in isolated hearts from normocholesterolemic rats.

Journal: European journal of pharmacology 20080610

Title: Efficacy of manidipine/delapril versus losartan/hydrochlorothiazide fixed combinations in patients with hypertension and diabetes.

Journal: Journal of hypertension 20080401

Title: Effect of delapril/manidipine vs olmesartan/ hydrochlorothiazide combination on insulin sensitivity and fibrinogen in obese hypertensive patients.

Journal: Internal medicine (Tokyo, Japan) 20080101

Title: Effects of manidipine/delapril versus olmesartan/hydrochlorothiazide combination therapy in elderly hypertensive patients with type 2 diabetes mellitus.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20080101

Title: [Evaluation of efficacy and safety of manidipine hydrochloride among essential hypertensive patients: Substitution from branded product (Calslot) to Generic Product (Manidip)].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20071201

Title: Addition of manidipine improves the antiproteinuric effect of candesartan in hypertensive patients with type II diabetes and microalbuminuria.

Journal: American journal of hypertension 20071001

Title: Determination and pharmacokinetics of manidipine in human plasma by HPLC/ESIMS.

Journal: Biomedical chromatography : BMC 20070801

Title: Manidipine-delapril combination in the management of hypertension.

Journal: Vascular health and risk management 20070601

Title: Effects of compression on the interaction between 1,4-dihydropyridine compounds and lactose monohydrate (II): differences in powder properties of 1,4-dihydropyridine compounds.

Journal: Chemical & pharmaceutical bulletin 20070501

Title: Manidipine plus delapril in patients with Type 2 diabetes and hypertension: reducing cardiovascular risk and end-organ damage.

Journal: Expert review of cardiovascular therapy 20070301

Title: Effect on the development of ankle edema of adding delapril to manidipine in patients with mild to moderate essential hypertension: a three-way crossover study.

Journal: Clinical therapeutics 20070301

Title: Angiotensin II receptor blocker provides pancreatic beta-cell protection independent of blood pressure lowering in diabetic db/db mice.

Journal: Acta pharmacologica Sinica 20070201

Title: Antihypertensive efficacy and safety of manidipine versus amlodipine in elderly subjects with isolated systolic hypertension: MAISH study.

Journal: Clinical drug investigation 20070101

Title: [Calcium channel-blockers for managing metabolic syndrome-associated hypertension. Trials with manidipine].

Journal: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20070101

Title: Stereoselective interaction of manidipine and grapefruit juice: a new twist on an old tale.

Journal: British journal of clinical pharmacology 20060501

Title: Effect of grapefruit juice on the disposition of manidipine enantiomers in healthy subjects.

Journal: British journal of clinical pharmacology 20060501

Title: Delapril/manidipine.

Journal: Drugs 20060101

Title: Delapril/manidipine: viewpoints.

Journal: Drugs 20060101

Title: Effect of successful hypertension control by manidipine or lisinopril on albuminuria and left ventricular mass in diabetic hypertensive patients with microalbuminuria.

Journal: European journal of clinical pharmacology 20050801

Title: Calcium channel blockades exhibit anti-inflammatory and antioxidative effects by augmentation of endothelial nitric oxide synthase and the inhibition of angiotensin converting enzyme in the N(G)-nitro-L-arginine methyl ester-induced hypertensive rat aorta: vasoprotective effects beyond the blood pressure-lowering effects of amlodipine and manidipine.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20050801

Title: Fixed combination of manidipine and delapril in the treatment of mild to moderate essential hypertension: evaluation by 24-hour ambulatory blood pressure monitoring.

Journal: Blood pressure. Supplement 20050701

Title: Effect of manidipine as compared to atenolol on platelet aggregation in elderly patients with isolated systolic hypertension and type II diabetes mellitus.

Journal: Journal of cardiovascular pharmacology 20050401

Title: Manidipine versus enalapril monotherapy in patients with hypertension and type 2 diabetes mellitus: a multicenter, randomized, double-blind, 24-week study.

Journal: Clinical therapeutics 20050201

Title: Vascular effects of calcium channel antagonists: new evidence.

Journal: Drugs 20050101

Title: Antihypertensive effect of manidipine.

Journal: Drugs 20050101

Title: Renal protection in hypertensive patients: selection of antihypertensive therapy.

Journal: Drugs 20050101

Title: Closing remarks: current position of calcium channel antagonists in hypertension--the role of manidipine.

Journal: Drugs 20050101

Title: Role of manidipine in the management of patients with hypertension.

Journal: Expert review of cardiovascular therapy 20041101

Title: Effect of delapril-manidipine combination vs irbesartan-hydrochlorothiazide combination on fibrinolytic function in hypertensive patients with type II diabetes mellitus.

Journal: Journal of human hypertension 20041001

Title: Effects of cyclooxygenase inhibition on endothelial function in hypertensive patients treated with angiotensin-converting enzyme inhibitors.

Journal: Clinical cardiology 20040901

Title: Efficacy and safety of delapril plus manidipine compared with enalapril plus hydrochlorothiazide in mild to moderate essential hypertension: results of a randomized trial.

Journal: Clinical therapeutics 20040901

Title: Effects of the long-acting calcium channel blockers, amlodipine, manidipine and cilnidipine on steroid hormones and insulin resistance in hypertensive obese patients.

Journal: Internal medicine (Tokyo, Japan) 20040701

Title: Effect of manidipine on gene expression and protein level of oxidative stress-related proteins: p22phox and HO-1: relevance for antihypertensive and anti-remodeling effects.

Journal: Journal of cardiovascular pharmacology 20040401

Title: Orally administered benidipine and manidipine prevent ischemia-reperfusion injury in the rat heart.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20040301

Title: Efficacy and tolerability of manidipine in the treatment of hypertension in patients with non-diabetic chronic kidney disease without glomerular disease. Prospective, randomized, double-blind study of parallel groups in comparison with enalapril.

Journal: Journal of nephrology 20040101

Title: Manidipine: a review of its use in the management of hypertension.

Journal: Drugs 20040101

Title: Therapeutic profile of manidipine and lercanidipine in hypertensive patients.

Journal: Advances in therapy 20040101

Title: Multivariate least squares regression applied to the spectrophotometric analysis of manidipine and its main photoproduct.

Journal: Farmaco (Societa chimica italiana : 1989) 20030901

Title: Effects of manidipine and nifedipine on blood pressure and renal function in patients with chronic renal failure: a multicenter randomized controlled trial.

Journal: Renal failure 20030901

Title: Pharmacokinetics and tolerability of a new manidipine and delapril fixed oral combination in young and elderly subjects.

Journal: Arzneimittel-Forschung 20030101

Title: Single oral dose pharmacokinetic interaction study of manidipine and delapril in healthy volunteers.

Journal: Arzneimittel-Forschung 20030101

Title: Effects of dihydropyridine-type Ca2+ antagonists on the renal arterial tree in spontaneously hypertensive rats.

Journal: Journal of cardiovascular pharmacology 20020101

Title: Treatment of gingival overgrowth induced by manidipine administration. A case report.

Journal: Journal of periodontology 20020101

Title: Neuroprotective effect of treatment with calcium antagonists on hypertensive retina.

Journal: Clinical and experimental hypertension (New York, N.Y. : 1993) 20020101

Title: Hypertensive brain damage: comparative evaluation of protective effect of treatment with dihydropyridine derivatives in spontaneously hypertensive rats.

Journal: Mechanisms of ageing and development 20011101

Title: [Manidipine in the treatment of stage I and II essential hypertension patients with overweight or android obesity. A Brazilian multicentre study of efficacy, tolerability and metabolic effects].

Journal: Arquivos brasileiros de cardiologia 20011101

Title: Efficacy, tolerability, and impact on quality of life of long-term treatment with manidipine or amlodipine in patients with essential hypertension.

Journal: Journal of cardiovascular pharmacology 20011001

Title: Effects of candesartan on cough and bronchial hyperresponsiveness in mildly to moderately hypertensive patients with symptomatic asthma.

Journal: Circulation 20010717

Title: Influence of treatment with Ca(2+) antagonists on cerebral vasculature of spontaneously hypertensive rats.

Journal: Mechanisms of ageing and development 20010601

Title: Effects on urinary albumin excretion and renal function changes by delapril and manidipine in normotensive type 2 diabetic patients with microalbuminuria.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20010201

Title: Spectrophotometric determination of manidipine dihydrochloride based on formation of charge-transfer complex with iodine.

Journal: Bollettino chimico farmaceutico 20010101

Title: Manidipine: a review of its use in hypertension.

Journal: Drugs 20010101

Title: Nephroprotective effect of treatment with calcium channel blockers in spontaneously hypertensive rats.

Journal: The Journal of pharmacology and experimental therapeutics 20000901

Title: Antihypertensive efficacy of manidipine and enalapril in hypertensive diabetic patients.

Journal: Journal of cardiovascular pharmacology 20000601

Title: Catalepsy induced by calcium channel blockers in mice.

Journal: Biopharmaceutics & drug disposition 19980301

Title: Effect of manidipine hydrochloride, a calcium antagonist, on isoproterenol-induced left ventricular hypertrophy.

Journal: Japanese circulation journal 19980101

Title: Role of angiotensin II in reflex tachycardia during hypotension caused by a calcium channel blocker.

Journal: Clinical and experimental hypertension (New York, N.Y. : 1993) 19960701

Title: Catalepsy induced by manidipine, a calcium channel blocker, in mice.

Journal: The Journal of pharmacy and pharmacology 19960401

Title: Buset Ríos N, Rodríguez Esparragón F, Fernández-Andrade Rodríguez C, et al. Vascular and metabolic properties of manidipine . Nefrologia. 2011;31(3):268-74.

Title: Costa S, Zimetti F, Pedrelli M, et al. Manidipine reduces pro-inflammatory cytokines secretion in human endothelial cells and macrophages. Pharmacol Res. 2010 Sep;62(3):265-70.

Title: Cavalieri L, Cremonesi G. Metabolic effects of manidipine. Am J Cardiovasc Drugs. 2009;9(3):163-76. doi: 10.2165/00129784-200909030-00004.

Title: Roca-Cusachs A, Triposkiadis F. Antihypertensive effect of manidipine. Drugs. 2005;65 Suppl 2:11-9.

Title: Nagaoka A. Pharmacologic characteristics of a new calcium antagonist, manidipine: beneficial effects on renal circulation and vascular changes. Am Heart J. 1993 Feb;125(2 Pt 2):560-5.

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Tags:89226-75-5 Molecular Formula|89226-75-5 MDL|89226-75-5 SMILES|89226-75-5 Manidipine DiHCl