Home Amines 89459-25-6
89459-25-6,MFCD00869683
Catalog No.:AA01CB8L

89459-25-6 | 4-Acridinecarboxamide, N-[2-(dimethylamino)ethyl]-

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2.5mg
3 weeks  
$553.00   $387.00
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5mg
3 weeks  
$1,015.00   $710.00
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10mg
3 weeks  
$1,766.00   $1,236.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01CB8L
Chemical Name:
4-Acridinecarboxamide, N-[2-(dimethylamino)ethyl]-
CAS Number:
89459-25-6
Molecular Formula:
C18H19N3O
Molecular Weight:
293.3630
MDL Number:
MFCD00869683
SMILES:
CN(CCNC(=O)c1cccc2c1nc1ccccc1c2)C
Properties
Computed Properties
 
Complexity:
385  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
3.3  

Literature

Title: Hydralazine as a selective probe inactivator of aldehyde oxidase in human hepatocytes: estimation of the contribution of aldehyde oxidase to metabolic clearance.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120701

Title: Beyond DNA binding - a review of the potential mechanisms mediating quinacrine's therapeutic activities in parasitic infections, inflammation, and cancers.

Journal: Cell communication and signaling : CCS 20110101

Title: Intracellular trafficking as a determinant of AS-DACA cytotoxicity in rhabdomyosarcoma cells.

Journal: BMC cell biology 20110101

Title: Attenuation of cytotoxic natural product DNA intercalating agents by caffeine.

Journal: Scientia pharmaceutica 20110101

Title: In vitro-in vivo correlation for intrinsic clearance for drugs metabolized by human aldehyde oxidase.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20100801

Title: In vitro assessment of novel transcription inhibitors and topoisomerase poisons in rhabdomyosarcoma cell lines.

Journal: Cancer chemotherapy and pharmacology 20091101

Title: Early tumor drug pharmacokinetics is influenced by tumor perfusion but not plasma drug exposure.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20081215

Title: The role of topoisomerases and RNA transcription in the action of the antitumour benzonaphthyridine derivative SN 28049.

Journal: Cancer chemotherapy and pharmacology 20081001

Title: Design, synthesis and preliminary biological evaluation of acridine compounds as potential agents for a combined targeted chemo-radionuclide therapy approach to melanoma.

Journal: Bioorganic & medicinal chemistry 20080815

Title: Plasma pharmacokinetic evaluation of cytotoxic agents radiolabelled with positron emitting radioisotopes.

Journal: Cancer chemotherapy and pharmacology 20080401

Title: Inhibition of human CYP1A2 oxidation of 5,6-dimethyl-xanthenone-4-acetic acid by acridines: a molecular modelling study.

Journal: Clinical and experimental pharmacology & physiology 20050801

Title: Mechanisms of action of DNA intercalating acridine-based drugs: how important are contributions from electron transfer and oxidative stress?

Journal: Current medicinal chemistry 20031201

Title: Synthesis and cytotoxic activity of carboxamide derivatives of benzo[b][1,6]naphthyridines.

Journal: Journal of medicinal chemistry 20030313

Title: Use of positron emission tomography in pharmacokinetic studies to investigate therapeutic advantage in a phase I study of 120-hour intravenous infusion XR5000.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030115

Title: Pharmacokinetics of radiolabelled anticancer drugs for positron emission tomography.

Journal: Current pharmaceutical design 20030101

Title: Inter-strain variability in aldehyde oxidase activity in the mouse.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20020701

Title: Kinetic studies of the binding of acridinecarboxamide topoisomerase poisons to DNA: implications for mode of binding of ligands with uncharged chromophores.

Journal: Journal of medicinal chemistry 20020214

Title: Topoisomerase I/II selectivity among derivatives of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA).

Journal: Anti-cancer drug design 20011201

Title: Effects of anticancer drugs on the metabolism of the anticancer drug 5,6-dimethylxanthenone-4-acetic (DMXAA) by human liver microsomes.

Journal: British journal of clinical pharmacology 20010801

Title: Extravascular transport of the DNA intercalator and topoisomerase poison N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide (DACA): diffusion and metabolism in multicellular layers of tumor cells.

Journal: The Journal of pharmacology and experimental therapeutics 20010601

Title: Comparative biodistribution and metabolism of carbon-11-labeled N-[2-(dimethylamino)ethyl]acridine-4-carboxamide and DNA-intercalating analogues.

Journal: Cancer research 20010401

Title: Individual variation in hepatic aldehyde oxidase activity.

Journal: IUBMB life 20010401

Title: Pharmacokinetic evaluation of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide in patients by positron emission tomography.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010301

Title: Effects of protein binding on the in vitro activity of antitumour acridine derivatives and related anticancer drugs.

Journal: Cancer chemotherapy and pharmacology 20000101

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Tags:89459-25-6 Molecular Formula|89459-25-6 MDL|89459-25-6 SMILES|89459-25-6 4-Acridinecarboxamide, N-[2-(dimethylamino)ethyl]-