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895519-90-1,MFCD18633213
Catalog No.:AA00GU87

895519-90-1 | Flumatinib

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Purity
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Price(USD)
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5mg
≥98%
in stock  
$52.00   $36.00
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10mg
≥98%
in stock  
$89.00   $62.00
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25mg
≥98%
in stock  
$155.00   $108.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00GU87
Chemical Name:
Flumatinib
CAS Number:
895519-90-1
Molecular Formula:
C29H29F3N8O
Molecular Weight:
562.5888
MDL Number:
MFCD18633213
SMILES:
CN1CCN(CC1)Cc1ccc(cc1C(F)(F)F)C(=O)Nc1cnc(c(c1)Nc1nccc(n1)c1cccnc1)C
Properties
Computed Properties
 
Complexity:
841  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
41  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
7  
XLogP3:
3.4  

Downstream Synthesis Route

[1]CurrentPatentAssignee:JIANGSUMINGTAIINVESTMENTGROUPLTD-CN102796079,2016,BLocationinpatent:Paragraph0021-0024

[2]CurrentPatentAssignee:HANSOHPHARMACEUTICALGROUPCOLTD-CN115197168,2022,ALocationinpatent:Paragraph0102-0104

[1]CurrentPatentAssignee:HANSOHPHARMACEUTICALGROUPCOLTD-CN111072636,2020,A

[1]CurrentPatentAssignee:HANSOHPHARMACEUTICALGROUPCOLTD-CN111072636,2020,A

[1]CurrentPatentAssignee:HANSOHPHARMACEUTICALGROUPCOLTD-CN111072636,2020,ALocationinpatent:Paragraph0042;0073-0084

Literature

Title: Flumatinib, a selective inhibitor of BCR-ABL/PDGFR/KIT, effectively overcomes drug resistance of certain KIT mutants.

Journal: Cancer science 20140101

Title: Simultaneous determination of flumatinib and its two major metabolites in plasma of chronic myelogenous leukemia patients by liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120501

Title: HH-GV-678, a novel selective inhibitor of Bcr-Abl, outperforms imatinib and effectively overrides imatinib resistance.

Journal: Leukemia 20101001

Title: Metabolism of flumatinib, a novel antineoplastic tyrosine kinase inhibitor, in chronic myelogenous leukemia patients.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20100801

Title: [Effect of a novel tyrosine kinase inhibitor HHGV678 on growth inhibition of Bcr-Abl wild type and IM-resistant cell lines in vitro].

Journal: Zhongguo shi yan xue ye xue za zhi 20081001

Title: Luo H, et al. HH-GV-678, a novel selective inhibitor of Bcr-Abl, outperforms imatinib and effectively overrides imatinib resistance. Leukemia. 2010 Oct;24(10):1807-9.

Title: Zhao J, et al. Flumatinib, a selective inhibitor of BCR-ABL/PDGFR/KIT, effectively overcomes drug resistance of certain KIT mutants. Cancer Sci. 2013 Nov 10.

Title: Gong A, et al. Metabolism of flumatinib, a novel antineoplastic tyrosine kinase inhibitor, in chronic myelogenous leukemia patients. Drug Metab Dispos. 2010 Aug;38(8):1328-40.

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SDS
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