Home Other Building Blocks 899805-25-5
899805-25-5,MFCD23160040
Catalog No.:AA00GTZK

899805-25-5 | CC 930

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$16.00   $11.00
- +
2mg
98%
in stock  
$27.00   $19.00
- +
5mg
98%
in stock  
$39.00   $28.00
- +
10mg
98%
in stock  
$58.00   $41.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00GTZK
Chemical Name:
CC 930
CAS Number:
899805-25-5
Molecular Formula:
C21H24ClF3N6O2
Molecular Weight:
484.9025
MDL Number:
MFCD23160040
SMILES:
OC1CCC(CC1)Nc1ncc2c(n1)n([C@@H]1COCC1)c(n2)Nc1c(F)cc(cc1F)F.Cl
Properties
Computed Properties
 
Complexity:
618  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
5  
XLogP3:
3.1  

Literature

Title: JNK inhibition reduces lung remodeling and pulmonary fibrotic systemic markers.

Journal: Clinical and translational medicine 20160101

Title: Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis.

Journal: Annals of the rheumatic diseases 20120501

Title: Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor.

Journal: Bioorganic & medicinal chemistry letters 20120201

Title: Evaluation of JNK blockade as an early intervention treatment for type 1 diabetic nephropathy in hypertensive rats.

Journal: American journal of nephrology 20110101

Title: Plantevin Krenitsky V, et al. Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor. Bioorg Med Chem Lett. 2012 Feb 1;22(3):1433-8.

Title: Gan LT, et al. Hepatocyte free cholesterol lipotoxicity results from JNK1-mediated mitochondrial injury and is HMGB1 and TLR4-dependent. J Hepatol. 2014 Dec;61(6):1376-84.

Title: Reich N, et al. Jun N-terminal kinase as a potential molecular target for prevention and treatment of dermal fibrosis. Ann Rheum Dis. 2012 May;71(5):737-45.

Title: Tavernier SJ, et al. Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival. Nat Cell Biol. 2017 Jun;19(6):698-710.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 899805-25-5
Tags:899805-25-5 Molecular Formula|899805-25-5 MDL|899805-25-5 SMILES|899805-25-5 CC 930