Title: García-Vilas JA, et al. 4-methylumbelliferone inhibits angiogenesis in vitro and in vivo. J Agric Food Chem. 2013 May 1;61(17):4063-71.
4-Methylumbelliferone is a key compound widely utilized in the synthesis of various medicinal compounds and fluorescent probes. It serves as a foundational component for the creation of diverse molecules with pharmaceutical and diagnostic applications. Specifically, it is employed in the production of coumarin triazole derivatives, which hold promise as antimicrobial agents, and coumarin salen-based fluorescence sensors used for detecting Mg2+. Additionally, it plays a crucial role in the synthesis of pyranocoumarin derivatives, which exhibit potential as anti-hyperglycemic and anti-dyslipidemic agents, as well as coumarin piperazine derivatives, which are being explored as potential multireceptor atypical antipsychotics. Moreover, 4-Methylumbelliferone is essential in the creation of 4-methylumbelliferyl T-antigen, a substrate utilized in enzymatic assays for endo-α-N-acetylgalactosaminidase. Overall, 4-Methylumbelliferone serves as a versatile building block in the realm of medicinal chemistry and diagnostics, enabling the development of novel therapeutic and diagnostic agents.
