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900573-88-8,MFCD26142530
Catalog No.:AA00GU12

900573-88-8 | JI-101

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98+%
in stock  
$39.00   $28.00
- +
10mg
98+%
in stock  
$60.00   $42.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00GU12
Chemical Name:
JI-101
CAS Number:
900573-88-8
Molecular Formula:
C22H20BrN5O2
Molecular Weight:
466.3305
MDL Number:
MFCD26142530
SMILES:
COc1ccc(cc1NC(=O)Nc1cccc2c1ccn2Cc1cc[nH]c(=N)c1)Br
Properties
Computed Properties
 
Complexity:
582  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
5  
XLogP3:
3.4  

Literature

Title: A strategy for extending the applicability of a validated plasma calibration curve to quantitative measurements in multiple tissue homogenate samples: a case study from a rat tissue distribution study of JI-101, a triple kinase inhibitor.

Journal: Biomedical chromatography : BMC 20120401

Title: Highly sensitive method for the determination of JI-101, a multi-kinase inhibitor in human plasma and urine by LC-MS/MS-ESI: method validation and application to a clinical pharmacokinetic study.

Journal: Biomedical chromatography : BMC 20120201

Title: Pharmacokinetics, tissue distribution and identification of putative metabolites of JI-101 - a novel triple kinase inhibitor in rats.

Journal: Arzneimittel-Forschung 20120101

Title: Highly sensitive method for the determination of a novel triple kinase inhibitor with anti-cancer activity, JI-101, in rat plasma by liquid chromatography-electrospray ionization tandem mass spectrometry: application to a pharmacokinetic study.

Journal: Biomedical chromatography : BMC 20110701

Title: Gurav SD, et al. Pharmacokinetics, tissue distribution and identification of putative metabolites of JI-101 - a novel triple kinase inhibitor in rats. Arzneimittelforschung. 2012 Jan;62(1):27-34.

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Tags:900573-88-8 Molecular Formula|900573-88-8 MDL|900573-88-8 SMILES|900573-88-8 JI-101