Home Pyridines 905281-76-7
905281-76-7,MFCD16875916
Catalog No.:AA006CM5

905281-76-7 | (e)-5-(1-(2-hydroxyethyl)-3-(pyridin-4-yl)-1h-pyrazol-4-yl)-2,3-dihydroinden-1-one oxime

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$46.00   $32.00
- +
5mg
≥95%
in stock  
$166.00   $116.00
- +
10mg
≥95%
in stock  
$285.00   $199.00
- +
25mg
96%
in stock  
$552.00   $387.00
- +
50mg
99% (HPLC)
in stock  
$1,040.00   $728.00
- +
100mg
96%
in stock  
$1,329.00   $930.00
- +
500mg
99% (HPLC)
in stock  
$5,515.00   $3,861.00
- +
1000mg
99% (HPLC)
in stock  
$8,787.00   $6,151.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA006CM5
Chemical Name:
(e)-5-(1-(2-hydroxyethyl)-3-(pyridin-4-yl)-1h-pyrazol-4-yl)-2,3-dihydroinden-1-one oxime
CAS Number:
905281-76-7
Molecular Formula:
C19H18N4O2
Molecular Weight:
334.3718
MDL Number:
MFCD16875916
SMILES:
OCCn1cc(c(n1)c1ccncc1)c1ccc2c(c1)CCC2=NO
Properties
Properties
 
Form:
Solid  
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
480  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
1.7  

Literature

Title: Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects.

Journal: International journal of molecular sciences 20150101

Title: Conformation-specific effects of Raf kinase inhibitors.

Journal: Journal of medicinal chemistry 20120913

Title: Comprehensive analysis of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111030

Title: The discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20110215

Title: RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.

Journal: Nature 20100318

Title: Disposition of GDC-0879, a B-RAF kinase inhibitor in preclinical species.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20090901

Title: Pharmacodynamics of 2-[4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridine-4-yl)-1H-pyrazol-1-yl]ethan-1-ol (GDC-0879), a potent and selective B-Raf kinase inhibitor: understanding relationships between systemic concentrations, phosphorylated mitogen-activated protein kinase kinase 1 inhibition, and efficacy.

Journal: The Journal of pharmacology and experimental therapeutics 20090401

Title: Antitumor efficacy of the novel RAF inhibitor GDC-0879 is predicted by BRAFV600E mutational status and sustained extracellular signal-regulated kinase/mitogen-activated protein kinase pathway suppression.

Journal: Cancer research 20090401

Title: Potent and selective pyrazole-based inhibitors of B-Raf kinase.

Journal: Bioorganic & medicinal chemistry letters 20080815

Title: Hansen JD, et al. Potent and selective pyrazole-based inhibitors of B-Raf kinase. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4692-5.

Title: Wong H, et al. Pharmacodynamics of 2--[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl-3-(pyridine-4-yl)-1H-pyrazol-1-ylethan-1-ol (GDC-0879), a potent and selective B-Raf kinase inhibitor: understanding relationships between systemic concentrations, phosphorylated mitogen-activated protein kinase kinase 1 inhibition, and efficacy. J Pharmacol Exp Ther. 2009 Apr;329(1):360-7.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 905281-76-7
Tags:905281-76-7 Molecular Formula|905281-76-7 MDL|905281-76-7 SMILES|905281-76-7 (e)-5-(1-(2-hydroxyethyl)-3-(pyridin-4-yl)-1h-pyrazol-4-yl)-2,3-dihydroinden-1-one oxime