Home Amines 905973-89-9
905973-89-9,MFCD09038682
Catalog No.:AA00GTZQ

905973-89-9 | 2,2-Diphenyl-N-(2,2,2-trichloro-1-{[(4-fluoro-3-nitrophenyl)carbamothioyl]amino}ethyl)acetamide

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Purity
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5mg
98%(HPLC)
in stock  
$47.00   $33.00
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10mg
98%(HPLC)
in stock  
$91.00   $64.00
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25mg
98%(HPLC)
in stock  
$181.00   $127.00
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50mg
≥98%
in stock  
$315.00   $220.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00GTZQ
Chemical Name:
2,2-Diphenyl-N-(2,2,2-trichloro-1-{[(4-fluoro-3-nitrophenyl)carbamothioyl]amino}ethyl)acetamide
CAS Number:
905973-89-9
Molecular Formula:
C23H18Cl3FN4O3S
Molecular Weight:
555.8364
MDL Number:
MFCD09038682
SMILES:
S=C(NC(C(Cl)(Cl)Cl)NC(=O)C(c1ccccc1)c1ccccc1)Nc1ccc(c(c1)[N+](=O)[O-])F
Properties
Properties
 
Form:
Solid  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
725  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
1  
XLogP3:
6.1  

Literature

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: CGK733 enhances multinucleated cell formation and cytotoxicity induced by taxol in Chk1-deficient HBV-positive hepatocellular carcinoma cells.

Journal: Biochemical and biophysical research communications 20120525

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111101

Title: CGK733 does not inhibit ATM or ATR kinase activity in H460 human lung cancer cells.

Journal: DNA repair 20111010

Title: ATM is the predominant kinase involved in the phosphorylation of histone H2AX after heating.

Journal: Journal of radiation research 20100101

Title: Scientific misconduct. Science retracts discredited paper; bitter patent dispute continues.

Journal: Science (New York, N.Y.) 20090424

Title: The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation.

Journal: Radiation oncology (London, England) 20090101

Title: Ataxia telangiectasia mutated and p21CIP1 modulate cell survival of drug-induced senescent tumor cells: implications for chemotherapy.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20080315

Title: Small molecule-based reversible reprogramming of cellular lifespan.

Journal: Nature chemical biology 20060701

Title: Wang H, et al. CGK733 enhances multinucleated cell formation and cytotoxicity induced by taxol in Chk1-deficient HBV-positive hepatocellular carcinoma cells. Biochem Biophys Res Commun. 2012 May 25;422(1):103-8.

Title: Alao JP, et al. The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation. Radiat Oncol. 2009 Nov 10;4:51.

Title: Williams TM, et al. Molecular imaging of the ATM kinase activity. Int J Radiat Oncol Biol Phys. 2013 Aug 1;86(5):969-77.

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Tags:905973-89-9 Molecular Formula|905973-89-9 MDL|905973-89-9 SMILES|905973-89-9 2,2-Diphenyl-N-(2,2,2-trichloro-1-{[(4-fluoro-3-nitrophenyl)carbamothioyl]amino}ethyl)acetamide