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90614-48-5,MFCD00038707
Catalog No.:AA00GRP0

90614-48-5 | DIPROTIN A

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10mg
≥98%
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$82.00   $57.00
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25mg
≥98%
in stock  
$129.00   $90.00
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50mg
≥98%
in stock  
$238.00   $166.00
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100mg
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$432.00   $302.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00GRP0
Chemical Name:
DIPROTIN A
CAS Number:
90614-48-5
Molecular Formula:
C17H31N3O4
Molecular Weight:
341.4457
MDL Number:
MFCD00038707
SMILES:
CC[C@@H]([C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H]([C@H](CC)C)N)C
Properties
Computed Properties
 
Complexity:
469  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
8  
XLogP3:
-1  

Literature

Title: Dipeptidyl-peptidase IV inhibitory activity of peptides derived from tuna cooking juice hydrolysates.

Journal: Peptides 20120501

Title: Dipeptidyl peptidase IV (DPPIV/CD26) inhibition does not improve engraftment of unfractionated syngeneic or allogeneic bone marrow after nonmyeloablative conditioning.

Journal: Experimental hematology 20120201

Title: High mobility group box 1 is a novel substrate of dipeptidyl peptidase-IV.

Journal: Diabetologia 20120101

Title: Non-competitive and selective dipeptidyl peptidase IV inhibitors with phenethylphenylphthalimide skeleton derived from thalidomide-related α-glucosidase inhibitors and liver X receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters 20110515

Title: Neutral aminopeptidase and dipeptidyl peptidase IV activities in plasma of monosodium glutamate obese and food-deprived rats.

Journal: Obesity (Silver Spring, Md.) 20100701

Title: Identification and characterization of dipeptidyl peptidase IV enzyme activity in the American crocodile (Crocodylus acutus).

Journal: Veterinary immunology and immunopathology 20100701

Title: The novel endomorphin degradation blockers Tyr-Pro-DClPhe-Phe-NH (EMDB-1) and Tyr-Pro-Ala-NH (EMDB-2) prolong endomorphin-2 action in rat ileum in vitro.

Journal: Chemical biology & drug design 20100701

Title: Intrathecally injected Ile-Pro-Ile, an inhibitor of membrane ectoenzyme dipeptidyl peptidase IV, is antihyperalgesic in rats by switching the enzyme from hydrolase to synthase functional mode to generate endomorphin 2.

Journal: European journal of pharmacology 20091012

Title: Immunoreactive endomorphin 2 is generated extracellularly in rat isolated L4,5 dorsal root ganglia by DPP-IV.

Journal: Regulatory peptides 20091009

Title: The effects of endomorphins on striatal [3H]GABA release induced by electrical stimulation: an in vitro superfusion study in rats.

Journal: Neurochemical research 20090501

Title: Inhibition of dipeptidyl peptidase-IV (DPP-IV) by atorvastatin.

Journal: Bioorganic & medicinal chemistry letters 20080115

Title: Modulation of substance P signaling by dipeptidyl peptidase-IV enzymatic activity in human glioma cell lines.

Journal: Physiological research 20080101

Title: The effects of endomorphins and diprotin A on striatal dopamine release induced by electrical stimulation-an in vitro superfusion study in rats.

Journal: Neurochemistry international 20061201

Title: Design and discovery of a novel dipeptidyl-peptidase IV (CD26)-based prodrug approach.

Journal: Journal of medicinal chemistry 20060824

Title: Enalapril increases ischemia-induced endothelial progenitor cell mobilization through manipulation of the CD26 system.

Journal: Journal of molecular and cellular cardiology 20060701

Title: Neuropeptide Y bioavailability is suppressed in the hindlimb of female Sprague-Dawley rats.

Journal: The Journal of physiology 20051015

Title: Function of a long-term, GLP-1-treated, insulin-secreting cell line is improved by preventing DPP IV-mediated degradation of GLP-1.

Journal: Diabetes, obesity & metabolism 20050901

Title: The role of substance P and bradykinin in the cough reflex and bronchoconstriction in guinea-pigs.

Journal: European journal of pharmacology 20050418

Title: Obligatory involvement of CD26/dipeptidyl peptidase IV in the activation of the antiretroviral tripeptide glycylprolylglycinamide (GPG-NH(2)).

Journal: The international journal of biochemistry & cell biology 20040901

Title: [Development of a new analgesic based on metabolism of endomorphin, an endogenous opioid peptide].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20040801

Title: Influence of dipeptidyl peptidase inhibitors on growth, peptidase activity, and ammonia production by ruminal microorganisms.

Journal: Current microbiology 20040801

Title: The purification and characterisation of novel dipeptidyl peptidase IV-like activity from bovine serum.

Journal: The international journal of biochemistry & cell biology 20040701

Title: The crystal structure of human dipeptidyl peptidase IV (DPPIV) complex with diprotin A.

Journal: Biological chemistry 20040601

Title: Degradation of endomorphin-2 at the supraspinal level in mice is initiated by dipeptidyl peptidase IV: an in vitro and in vivo study.

Journal: Biochemical pharmacology 20030815

Title: Structural basis of proline-specific exopeptidase activity as observed in human dipeptidyl peptidase-IV.

Journal: Structure (London, England : 1993) 20030801

Title: Cell surface peptidase CD26/dipeptidylpeptidase IV regulates CXCL12/stromal cell-derived factor-1 alpha-mediated chemotaxis of human cord blood CD34+ progenitor cells.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20021215

Title: Studies on the aminopeptidase activities of Porphyromonas gingivalis.

Journal: Oral microbiology and immunology 20010801

Title: Degradation and glycemic effects of His(7)-glucitol glucagon-like peptide-1(7-36)amide in obese diabetic ob/ob mice.

Journal: Regulatory peptides 20010112

Title: Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors.

Journal: Journal of medicinal chemistry 20000224

Title: Influence of several peptidase inhibitors on the pro-inflammatory effects of substance P, capsaicin and collagenase.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19961101

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