+1 858-523-8231
Login | Register
menu
AA Blocks, Building Blocks, Catalysts, Inhibitors
Login | Register
906673-24-3,MFCD17169940
Catalog No.:AA00GTY2

906673-24-3 | 4-((1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy)benzonitrile

Pack Size
Purity
Availability
Price(USD)
Quantity
  
10mg
98%
in stock  
$7.00   $5.00
- +
50mg
98%
in stock  
$13.00   $9.00
- +
250mg
98%
in stock  
$32.00   $23.00
- +
1g
98%
in stock  
$86.00   $61.00
- +
5g
97%
in stock  
$385.00   $269.00
- +
25g
98%
in stock  
$1,060.00   $742.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00GTY2
Chemical Name:
4-((1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy)benzonitrile
CAS Number:
906673-24-3
Molecular Formula:
C14H10BNO3
Molecular Weight:
251.0451
MDL Number:
MFCD17169940
SMILES:
N#Cc1ccc(cc1)Oc1ccc2c(c1)COB2O
Properties
Computed Properties
 
Complexity:
361  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  

Downstream Synthesis Route

[1]Patent:US2007/286822,2007,A1.Locationinpatent:Page/Pagecolumn47

906673-24-3   
4-(1-hydroxy-1,3-dihydrobenzoc1,2oxaborol-5-yloxy)benzoicacid 

[1]BioorganicandMedicinalChemistryLetters,2009,vol.19,p.2129-2132

[2]Patent:US2006/234981,2006,A1.Locationinpatent:Page/Pagecolumn30

[3]Patent:US2007/293457,2007,A1.Locationinpatent:Page/Pagecolumn44;46

[4]Patent:US2015/291629,2015,A1.Locationinpatent:Paragraph0589

[5]Patent:US2007/286822,2007,A1.Locationinpatent:Page/Pagecolumn47

906673-24-3   
1-hydroxy-5-4-(tetrazole-1-yl)phenoxy-2,1-benzoxaborole 

[1]Patent:US2006/234981,2006,A1.Locationinpatent:Page/Pagecolumn30

[2]Patent:US2007/293457,2007,A1.Locationinpatent:Page/Pagecolumn44;46

[3]Patent:US2015/291629,2015,A1.Locationinpatent:Paragraph0590

C25H32BNO5 
  906673-24-3 

[1]BioorganicandMedicinalChemistryLetters,2009,vol.19,p.2129-2132

[2]Patent:CN109517003,2019,A.Locationinpatent:Paragraph0097;0098;0102

Literature

Title: Crisaborole: Phosphodiesterase inhibitor for treatment of atopic dermatitis.

Journal: Drugs of today (Barcelona, Spain : 1998) 20170401

Title: Efficacy and safety of crisaborole ointment, a novel, nonsteroidal phosphodiesterase 4 (PDE4) inhibitor for the topical treatment of atopic dermatitis (AD) in children and adults.

Journal: Journal of the American Academy of Dermatology 20160901

Title: Tolerability of Crisaborole Ointment for Application on Sensitive Skin Areas: A Randomized, Double-Blind, Vehicle-Controlled Study in Healthy Volunteers.

Journal: American journal of clinical dermatology 20160101

Title: A review of phosphodiesterase-inhibition and the potential role for phosphodiesterase 4-inhibitors in clinical dermatology.

Journal: Dermatology online journal 20140516

Title: Design and synthesis of boron-containing PDE4 inhibitors using soft-drug strategy for potential dermatologic anti-inflammatory application.

Journal: Bioorganic & medicinal chemistry letters 20100401

Title: Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis.

Journal: Bioorganic & medicinal chemistry letters 20090415

Title: Akama T, et al. Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2129-32.

Title: Nazarian R, et al. AN-2728, a PDE4 inhibitor for the potential topical treatment of psoriasis and atopic dermatitis. Curr Opin Investig Drugs. 2009 Nov;10(11):1236-42.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
Submit
SDS
Related Products of 906673-24-3
Building Blocks
More >
Historical Records
391228-58-3

391228-58-3

 899905-31-8

899905-31-8

 888463-58-9

888463-58-9

 941992-60-5

941992-60-5

 1021094-04-1

1021094-04-1
Tags:906673-24-3 Molecular Formula|906673-24-3 MDL|906673-24-3 SMILES|906673-24-3 4-((1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy)benzonitrile
Catalog No.: AA00GTY2
906673-24-3,MFCD17169940
906673-24-3 | 4-((1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy)benzonitrile
Pack Size： 10mg
Purity： 98%
in stock
$7.00 $5.00
Pack Size： 50mg
Purity： 98%
in stock
$13.00 $9.00
Pack Size： 250mg
Purity： 98%
in stock
$32.00 $23.00
Pack Size： 1g
Purity： 98%
in stock
$86.00 $61.00
Pack Size： 5g
Purity： 97%
in stock
$385.00 $269.00
Pack Size： 25g
Purity： 98%
in stock
$1,060.00 $742.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00GTY2
Chemical Name: 4-((1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy)benzonitrile
CAS Number: 906673-24-3
Molecular Formula: C14H10BNO3
Molecular Weight: 251.0451
MDL Number: MFCD17169940
SMILES: N#Cc1ccc(cc1)Oc1ccc2c(c1)COB2O
Properties
Complexity: 361  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 19  
Hydrogen Bond Acceptor Count: 4  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 2  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
Downstream Synthesis Route
906673-24-3    947162-19-8 

[1]Patent:US2007/286822,2007,A1.Locationinpatent:Page/Pagecolumn47

906673-24-3   
4-(1-hydroxy-1,3-dihydrobenzoc1,2oxaborol-5-yloxy)benzoicacid 

[1]BioorganicandMedicinalChemistryLetters,2009,vol.19,p.2129-2132

[2]Patent:US2006/234981,2006,A1.Locationinpatent:Page/Pagecolumn30

[3]Patent:US2007/293457,2007,A1.Locationinpatent:Page/Pagecolumn44;46

[4]Patent:US2015/291629,2015,A1.Locationinpatent:Paragraph0589

[5]Patent:US2007/286822,2007,A1.Locationinpatent:Page/Pagecolumn47

906673-24-3   
1-hydroxy-5-4-(tetrazole-1-yl)phenoxy-2,1-benzoxaborole 

[1]Patent:US2006/234981,2006,A1.Locationinpatent:Page/Pagecolumn30

[2]Patent:US2007/293457,2007,A1.Locationinpatent:Page/Pagecolumn44;46

[3]Patent:US2015/291629,2015,A1.Locationinpatent:Paragraph0590

C25H32BNO5 
  906673-24-3 

[1]BioorganicandMedicinalChemistryLetters,2009,vol.19,p.2129-2132

[2]Patent:CN109517003,2019,A.Locationinpatent:Paragraph0097;0098;0102

Literature fold

Title: Crisaborole: Phosphodiesterase inhibitor for treatment of atopic dermatitis.

Journal: Drugs of today (Barcelona, Spain : 1998)20170401

Title: Efficacy and safety of crisaborole ointment, a novel, nonsteroidal phosphodiesterase 4 (PDE4) inhibitor for the topical treatment of atopic dermatitis (AD) in children and adults.

Journal: Journal of the American Academy of Dermatology20160901

Title: Tolerability of Crisaborole Ointment for Application on Sensitive Skin Areas: A Randomized, Double-Blind, Vehicle-Controlled Study in Healthy Volunteers.

Journal: American journal of clinical dermatology20160101

Title: A review of phosphodiesterase-inhibition and the potential role for phosphodiesterase 4-inhibitors in clinical dermatology.

Journal: Dermatology online journal20140516

Title: Design and synthesis of boron-containing PDE4 inhibitors using soft-drug strategy for potential dermatologic anti-inflammatory application.

Journal: Bioorganic & medicinal chemistry letters20100401

Title: Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis.

Journal: Bioorganic & medicinal chemistry letters20090415

Title: Akama T, et al. Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2129-32.

Title: Nazarian R, et al. AN-2728, a PDE4 inhibitor for the potential topical treatment of psoriasis and atopic dermatitis. Curr Opin Investig Drugs. 2009 Nov;10(11):1236-42.

Related Products of of 906673-24-3
Building Blocks More >
94079-81-9
94079-81-9
Poliumoside
AA00GU2V | MFCD23160017
942473-59-8
942473-59-8
2,5-Dibromoisonicotinic acid
AA00GU7B | MFCD08741485
923738-50-5
923738-50-5
Ethyl 6-chloro-3,4-dimethylthieno[2,3-b]pyridine-2-carboxylate
AA00GUB1 | MFCD08691337
923230-55-1
923230-55-1
2-[(4-Methyl-4h-1,2,4-triazol-3-yl)thio]aniline
AA00GUEA | MFCD08444421
884494-98-8
884494-98-8
2-Fluoro-5-(hydroxymethyl)-6-picoline
AA00GUND | MFCD05662401
874830-75-8
874830-75-8
1H-Indole-2,3-dione,5-bromo-7-fluoro-
AA00GUVM | MFCD06637294
91945-90-3
91945-90-3
2-(1,3-Bis(dimethylamino)allylidene)malononitrile
AA00GV9Z | MFCD01314677
91137-55-2
91137-55-2
4-Methyl-2-phenyloxazole-5-carboxylic acid
AA00GVF8 | MFCD01566859
934175-49-2
934175-49-2
2-(1H-Pyrazol-1-yl)acetohydrazide
AA00GVJR | MFCD04969829
91331-68-9
91331-68-9
3-Methyl-1-(2-methylphenyl)-1h-pyrazol-5-amine
AA00GVO7 | MFCD01605712
Historical Records
391228-58-3
391228-58-3
899905-31-8
899905-31-8
888463-58-9
888463-58-9
941992-60-5
941992-60-5
1021094-04-1
1021094-04-1
Submit
© 2017 AA BLOCKS, INC. All rights reserved.