Home Other Building Blocks 906805-42-3
906805-42-3,MFCD11042275
Catalog No.:AA006B1O

906805-42-3 | SCH 546738

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%
1 week  
$558.00   $391.00
- +
10mg
98%
1 week  
$781.00   $547.00
- +
50mg
98%
1 week  
$1,797.00   $1,258.00
- +
100mg
98%
1 week  
$2,431.00   $1,702.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA006B1O
Chemical Name:
SCH 546738
CAS Number:
906805-42-3
Molecular Formula:
C23H31Cl2N7O
Molecular Weight:
492.4445
MDL Number:
MFCD11042275
SMILES:
CC[C@H]1CN(CCN1C1CCN(CC1)Cc1ccc(cc1)Cl)c1nc(N)c(nc1Cl)C(=O)N
Properties
Properties
 
BP:
628.202 °C at 760 mmHg  
Storage:
Light sensitive;Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
642  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
4.1  

Literature

Title: Chemokine receptor antagonists.

Journal: Journal of medicinal chemistry 20121126

Title: III. Identification of novel CXCR3 chemokine receptor antagonists with a pyrazinyl-piperazinyl-piperidine scaffold.

Journal: Bioorganic & medicinal chemistry letters 20111201

Title: Jenh CH, et al. A selective and potent CXCR3 antagonist SCH 546738 attenuates the development of autoimmune diseases and delays graft rejection. BMC Immunol. 2012 Jan 10;13:2.

Title: Zhang X, et al. CXC chemokine receptor 3 promotes steatohepatitis in mice through mediating inflammatory cytokines, macrophages and autophagy. J Hepatol. 2016 Jan;64(1):160-70.

Title: Yue C, et al. STAT3 in CD8+ T Cells Inhibits Their Tumor Accumulation by Downregulating CXCR3/CXCL10 Axis. Cancer Immunol Res. 2015 Aug;3(8):864-870.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 906805-42-3
Tags:906805-42-3 Molecular Formula|906805-42-3 MDL|906805-42-3 SMILES|906805-42-3 SCH 546738