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Home Other Building Blocks 908115-27-5
908115-27-5,MFCD20526334
Catalog No.:AA00H0R3

908115-27-5 | PF-04929113

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$79.00   $55.00
- +
5mg
in stock  
$234.00   $164.00
- +
10mg
in stock  
$293.00   $205.00
- +
100mg
98%
in stock  
$926.00   $648.00
- +
250mg
98%
in stock  
$1,358.00   $950.00
- +
1g
98%
in stock  
$3,286.00   $2,300.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00H0R3
Chemical Name:
PF-04929113
CAS Number:
908115-27-5
Molecular Formula:
C25H30F3N5O4
Molecular Weight:
521.5320
MDL Number:
MFCD20526334
SMILES:
NCC(=O)OC1CCC(CC1)Nc1cc(ccc1C(=O)N)n1nc(c2c1CC(C)(C)CC2=O)C(F)(F)F
Properties
Computed Properties
 
Complexity:
877  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
37  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
7  
XLogP3:
3.5  

Downstream Synthesis Route
4-(2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo2,3-dpyrimidin-5-yl)ethyl)benzoicacid 
  908115-27-5   
(1r,4r)-4-((2-carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl2-(4-(2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo2,3-dpyrimidin-5-yl)ethyl)benzamido)acetate 

[1]CurrentPatentAssignee:SYNTAPHARMACEUTICALSCORP.-WO2015/38649,2015,A1Locationinpatent:Paragraph001570

Literature

Title: A phase I study of PF-04929113 (SNX-5422), an orally bioavailable heat shock protein 90 inhibitor, in patients with refractory solid tumor malignancies and lymphomas.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20111101

Title: Clusterin inhibition using OGX-011 synergistically enhances Hsp90 inhibitor activity by suppressing the heat shock response in castrate-resistant prostate cancer.

Journal: Cancer research 20110901

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SDS
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Tags:908115-27-5 Molecular Formula|908115-27-5 MDL|908115-27-5 SMILES|908115-27-5 PF-04929113