Home Other Building Blocks 910487-58-0
910487-58-0,MFCD22683833
Catalog No.:AA00GX1G

910487-58-0 | BAY 60-6583

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
≥98%
in stock  
$166.00   $116.00
- +
10mg
≥98%
in stock  
$219.00   $153.00
- +
25mg
≥98%
in stock  
$490.00   $343.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00GX1G
Chemical Name:
BAY 60-6583
CAS Number:
910487-58-0
Molecular Formula:
C19H17N5O2S
Molecular Weight:
379.4356
MDL Number:
MFCD22683833
SMILES:
N#Cc1c(N)nc(c(c1c1ccc(cc1)OCC1CC1)C#N)SCC(=O)N
Properties
Computed Properties
 
Complexity:
629  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
7  
XLogP3:
2.6  

Literature

Title: Activation of the A2B adenosine receptor in B16 melanomas induces CXCL12 expression in FAP-positive tumor stromal cells, enhancing tumor progression.

Journal: Oncotarget 20160927

Title: Adenosine receptor A2b on hematopoietic cells mediates LPS-induced migration of PMNs into the lung interstitium.

Journal: American journal of physiology. Lung cellular and molecular physiology 20120901

Title: Adenosine A₂B receptor agonism inhibits neointimal lesion development after arterial injury in apolipoprotein E-deficient mice.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20120901

Title: Adora2b signaling on bone marrow derived cells dampens myocardial ischemia-reperfusion injury.

Journal: Anesthesiology 20120601

Title: The A2b adenosine receptor modulates glucose homeostasis and obesity.

Journal: PloS one 20120101

Title: A role for the low-affinity A2B adenosine receptor in regulating superoxide generation by murine neutrophils.

Journal: The Journal of pharmacology and experimental therapeutics 20110901

Title: A2b adenosine receptors in cardioprotection: timing is everything.

Journal: Journal of molecular and cellular cardiology 20110301

Title: GPCR structure and activation: an essential role for the first extracellular loop in activating the adenosine A2B receptor.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110201

Title: Evidence that the acute phase of ischemic preconditioning does not require signaling by the A 2B adenosine receptor.

Journal: Journal of molecular and cellular cardiology 20101101

Title: Both A2a and A2b adenosine receptors at reperfusion are necessary to reduce infarct size in mouse hearts.

Journal: American journal of physiology. Heart and circulatory physiology 20101001

Title: Signaling through the A2B adenosine receptor dampens endotoxin-induced acute lung injury.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20100501

Title: Absence of adenosine-mediated aortic relaxation in A(2A) adenosine receptor knockout mice.

Journal: American journal of physiology. Heart and circulatory physiology 20091101

Title: Cutting Edge: A2B Adenosine receptor signaling provides potent protection during intestinal ischemia/reperfusion injury.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20090401

Title: Recent improvements in the development of A(2B) adenosine receptor agonists.

Journal: Purinergic signalling 20090301

Title: Recent improvements in the development of A(2B) adenosine receptor agonists.

Journal: Purinergic signalling 20081201

Title: A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice.

Journal: The Journal of clinical investigation 20081001

Title: The reno-vascular A2B adenosine receptor protects the kidney from ischemia.

Journal: PLoS medicine 20080601

Title: Up-regulation of A 2B adenosine receptor in A 2A adenosine receptor knockout mouse coronary artery.

Journal: Journal of molecular and cellular cardiology 20080501

Title: CD73-generated adenosine restricts lymphocyte migration into draining lymph nodes.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20080501

Title: Protein kinase C protects preconditioned rabbit hearts by increasing sensitivity of adenosine A2b-dependent signaling during early reperfusion.

Journal: Journal of molecular and cellular cardiology 20070901

Title: Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors.

Journal: Circulation 20070327

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