Home Other Building Blocks 911222-45-2
911222-45-2,MFCD18633253
Catalog No.:AA00GU1D

911222-45-2 | LY2603618

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Purity
Availability
Price(USD)
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5mg
≥95%
in stock  
$58.00   $40.00
- +
10mg
≥95%
in stock  
$103.00   $72.00
- +
25mg
≥95%
in stock  
$226.00   $158.00
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50mg
≥95%
in stock  
$338.00   $236.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00GU1D
Chemical Name:
LY2603618
CAS Number:
911222-45-2
Molecular Formula:
C18H22BrN5O3
Molecular Weight:
436.3030
MDL Number:
MFCD18633253
SMILES:
O=C(Nc1cc(Br)c(cc1OC[C@@H]1CNCCO1)C)Nc1cnc(cn1)C
Properties
Computed Properties
 
Complexity:
486  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
5  
XLogP3:
1.4  

Downstream Synthesis Route
Literature

Title: Characterization and preclinical development of LY2603618: a selective and potent Chk1 inhibitor.

Journal: Investigational new drugs 20140401

Title: Cellular impedance assays for predictive preclinical drug screening of kinase inhibitor cardiovascular toxicity.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20131001

Title: Summary of presentation from the targeted therapy in lung cancer meeting.

Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20111101

Title: New insights into checkpoint kinase 1 in the DNA damage response signaling network.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20100115

Title: King C, et al. Characterization and preclinical development of LY2603618: a selective and potent Chk1 inhibitor. Invest New Drugs. 2014 Apr;32(2):213-26.

Title: Wang G, et al. Panobinostat synergistically enhances the cytotoxic effects of cisplatin, doxorubicin or etoposide on high-risk neuroblastoma cells. PLoS One. 2013 Sep 30;8(9):e76662.

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SDS
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